The Effect of FGF21 and Its Genetic Variants on Food and Drug Cravings, Adipokines and Metabolic Traits

Epperlein, Sarah; Gebhardt, Claudia; Rohde, Kerstin; Chakaroun, Rima; Patt, M.; Schamarek, Imke; Kralisch, Susan; Heiker, John T.; Scholz, Markus; Stümvoll, Michael; Kovacs, Peter; Breitfeld, Jana; Tönjes, Anke

doi:10.3390/biomedicines9040345

Cited by 10 publications

(9 citation statements)

References 62 publications

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“…This study implies that the liver can regulate eating and lifestyle habits via producing different hormones like FGF21 ( 47 ). The other studies confirmed the role of FGF21 SNPs in addictive behaviors like eating habits and the amount of coffee consumption ( 48 – 51 ). Previous studies also showed the importance of FGF21 genetic variations in obesity (rs11665896) ( 50 ), fat and macronutrient intake (rs838147) ( 51 ), renal function in diabetic patients (rs2071699, rs838136, and rs499765) ( 52 ), and alcohol dependence (rs11665896) ( 53 ) which indirectly can have effects on steatosis of liver.…”

Section: Fgf21supporting

confidence: 63%

The role of FGF21 and its analogs on liver associated diseases

et al. 2022

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Fibroblast growth factor 21 (FGF21), a member of fibroblast growth factor family, is a hormone-like growth factor that is synthesized mainly in the liver and adipose tissue. FGF21 regulates lipid and glucose metabolism and has substantial roles in decreasing lipogenesis and increasing hepatic insulin sensitivity which causing lipid profile improvement. FGF21 genetic variations also affect nutritional and addictive behaviors such as smoking and alcohol consumption and eating sweets. The role of FGF21 in metabolic associated diseases like diabetes mellitus had been confirmed previously. Recently, several studies have demonstrated a correlation between FGF21 and liver diseases. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease worldwide. NAFLD has a wide range from simple steatosis to steatohepatitis with or without fibrosis and cirrhosis. Elevated serum levels of FGF21 associated with NAFLD and its pathogenesis. Alcoholic fatty liver disease (AFLD), another condition that cause liver injury, significantly increased FGF21 levels as a protective factor; FGF21 can reverse the progression of AFLD and can be a potential therapeutic agent for it. Also, NAFLD and AFLD are the most important risk factors for hepatocellular carcinoma (HCC) which is the fourth deadliest cancer in the world. Several studies showed that lack of FGF21 induced oncogenic condition and worsened HCC. In this review article, we intend to discuss different aspects of FGF21 in NAFLD, AFLD and HCC; including the role of FGF21 in pathophysiology of these conditions, the effects of FGF21 mutations, the possible use of the FGF21 as a biomarker in different stages of these diseases, as well as the usage of FGF21 and its analog molecules in the treatment of these diseases.

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Section: Fgf21supporting

confidence: 63%

The role of FGF21 and its analogs on liver associated diseases

et al. 2022

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“…The FGF21 resides on human chromosome 19 (19q13.33) and is comprised of three exons ( 23 ). The FGF21 is composed of 209 amino acids, of which 29 amino acids at the N-terminus form a signaling peptide ( 24 ).…”

Section: Biogenesis Characterization and Functions Of Fibroblast Grow...mentioning

confidence: 99%

Emerging roles of fibroblast growth factor 21 in critical disease

Fang

Li²,

Yang³

et al. 2022

Front. Cardiovasc. Med.

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In spite of the great progress in the management of critical diseases in recent years, its associated prevalence and mortality of multiple organ failure still remain high. As an endocrine hormone, fibroblast growth factor 21 (FGF21) functions to maintain homeostasis in the whole body. Recent studies have proved that FGF21 has promising potential effects in critical diseases. FGF21 has also been found to have a close relationship with the progression of critical diseases and has a great predictive function for organ failure. The level of FGF21 was elevated in both mouse models and human patients with sepsis or other critical illnesses. Moreover, it is a promising biomarker and has certain therapeutic roles in some critical diseases. We focus on the emerging roles of FGF21 and its potential effects in critical diseases including acute lung injury/acute respiratory distress syndrome (ALI/ARDS), acute myocardial injury (AMI), acute kidney injury (AKI), sepsis, and liver failure in this review. FGF21 has high application value and is worth further studying. Focusing on FGF21 may provide a new perspective for the management of the critical diseases.

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“…Several studies have reported that genetic variants in FGF2 1 might have implications for food and drug craving, alcohol preference and metabolic traits [ 5 , 41 , 42 ]. For example, rs838133 (a synonymous variant) is one of the most well-studied SNPs in FGF21 [ 42 ].…”

Section: Discussionmentioning

confidence: 99%