The effect of fentanyl on propofol requirements for day case anaesthesia

Thomas, Vaughan; Sutton, Debbie; Saunders, D. A.

doi:10.1111/j.1365-2044.1988.tb09077.x

Cited by 28 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thomas et al . [19] administered 100 mcg of fentanyl 1--5 min before induction with propofol in patients undergoing day care gynaecologic procedures. Compared to the control group, there were significant decreases in induction time, propofol dose and mean blood pressure with the use of fentanyl.…”

Section: Discussionmentioning

confidence: 99%

Effect of varying time intervals between fentanyl and propofol administration on propofol requirement for induction of anaesthesia: Randomised controlled trial

et al. 2019

View full text Add to dashboard Cite

Background and Aims:Administration of fentanyl before induction of anaesthesia with propofol should facilitate smooth induction, with a reduction in induction dose of propofol and its side effects. This study was designed to examine the effect of varying intervals between fentanyl and propofol administration on the dose of propofol required for induction of anaesthesia.Methods:After institutional ethical clearance, 129 American Society of Anesthesiologists physical status I--II patients, aged 18--65 years, undergoing elective surgery under general anaesthesia were randomised into three groups. Fentanyl 2 mcg/kg was administered immediately prior to, 3 and 5 min before induction with propofol in Groups 1, 2, and 3, respectively. Requirement of propofol induction dose and haemodynamic parameters was recorded. Statistical analysis was performed using software SPSS (SPSS Inc., Chicago, Illinois, USA).Results:Total dose of propofol required for induction was highest in Groups 1 and lowest Group 3 (Group 1 vs. 2 vs. 3: 86.28 ± 21.12 vs. 71.67 ± 21.68 vs. 59.98 ± 20.35 mg, P < 0.00001). Dose of propofol required per kg body weight was significantly higher in Group 1 (1.41 ± 0.34 mg/kg) compared to both Group 2 (1.14 ± 0.38 mg/kg) and Group 3 (0.97 ± 0.32 mg/kg) (P < 0.00001). Incidence of hypotension during induction was significantly lower in Group 3 (14%) and Group 2 (17.1%) than in Group 1 (35.6%; P = 0.03).Conclusion:Administering fentanyl 5 min prior to propofol causes marked reduction in the dose requirement of the latter along with a significantly decreased incidence of hypotension during induction.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of varying time intervals between fentanyl and propofol administration on propofol requirement for induction of anaesthesia: Randomised controlled trial

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, the propofol-sparing effect of fentanyl was not associated with an improvement in recovery time. 9 While propofol and alfentanil can be administered at different plasma concentrations to give an ideal ratio that could be used to give the most rapid return of consciousness, it requires a complicated step-down regime for both agents. 10 Vuyk et al, using a computer simulation program, have also suggested that the propofol concentrations that allow the most rapid return of consciousness are lower when it is administered with remifentanil than when combined with alfentanil or fentanyl.…”

Section: Discussionmentioning

confidence: 99%

Recovery from propofol anaesthesia supplemented with remifentanil

O'Hare

Mirakhur

Reid

et al. 2001

British Journal of Anaesthesia

View full text Add to dashboard Cite

We have examined the effects on recovery end-points of supplementation of a propofol-based anaesthetic with remifentanil. After induction of anaesthesia with propofol and remifentanil 1.0 microg kg(-1), 15 patients each were randomly allocated to target plasma propofol concentrations of 2, 3, 4 or 5 microg ml(-1) for maintenance of anaesthesia. Remifentanil was administered by infusion for supplementation in doses required for maintenance of adequate anaesthesia. All patients received 50% nitrous oxide in oxygen and ventilation was controlled. The total amount of drugs used and times to different recovery end-points were recorded. Cognitive function was also assessed using a Mini-Mental State questionnaire. The median dose of remifentanil for maintenance of adequate anaesthesia (excluding the initial bolus dose) in the four groups was 0.21, 0.15, 0.11 and 0.13 microg kg(-1) min(-1) respectively (P=0.0026). The median times to eye opening and orientation were shortest in the 2 microg ml(-1) group [6.0 and 6.5 min, 8.5 and 10.8 min, 13.4 and 15.8 min, and 14.2 and 19.5 min respectively in the propofol 2, 3, 4, and 5 microg ml(-1) groups respectively (P<0.001)]. The times to discharge from the recovery ward and the Mini-Mental State scores were not significantly different.

show abstract

“…pressure after propofol was not followed by histamine release but by a decreased cardiac output and decreased systemic vascular resistance [38]. Moreover, fentanyl which was used prior to propofol may cause a decrease in arterial blood pressure [39], however, it does not release histamine [40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%