The Effect of Fenestration of Lamina Terminalis on the Vasospasm and Shunt-Dependent Hydrocephalus in Patients Following Subarachnoid Haemorrhage

Hatefi, Masoud; Azhary, Shirzad; Naebaghaee, Hussein; Mohamadi, Hasan Reza; Jaafarpour, Molouk

doi:10.7860/jcdr/2015/13603.6264

Cited by 9 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, some other researchers questioned the efficacy of LTF to cut down shunt-dependence of patients [46]. As mentioned in our passage about the pathogenesis of acute HCP, LTF does not terminate or delay the fibrotic process of leptomeninges and arachnoid granulations, hence possibly improving CSF dynamics.…”

Section: Treatmentmentioning

confidence: 89%

Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment

Chen

Luo

Reis

et al. 2017

BioMed Research International

123

131

View full text Add to dashboard Cite

Hydrocephalus (HCP) is a common complication in patients with subarachnoid hemorrhage. In this review, we summarize the advanced research on HCP and discuss the understanding of the molecular originators of HCP and the development of diagnoses and remedies of HCP after SAH. It has been reported that inflammation, apoptosis, autophagy, and oxidative stress are the important causes of HCP, and well-known molecules including transforming growth factor, matrix metalloproteinases, and iron terminally lead to fibrosis and blockage of HCP. Potential medicines for HCP are still in preclinical status, and surgery is the most prevalent and efficient therapy, despite respective risks of different surgical methods, including lamina terminalis fenestration, ventricle-peritoneal shunting, and lumbar-peritoneal shunting. HCP remains an ailment that cannot be ignored and even with various solutions the medical community is still trying to understand and settle why and how it develops and accordingly improve the prognosis of these patients with HCP.

show abstract

Section: Treatmentmentioning

confidence: 89%

Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment

Chen

Luo

Reis

et al. 2017

BioMed Research International

123

131

View full text Add to dashboard Cite

show abstract

“…The lamina terminalis fenestration may have a limited role as it does not prevent fi brosis of the arachnoid as observed by some studies. 22 VP Shunt: The options for treatment are medical with use of Acetazolamide or surgical, like lumbar drain (single or repetitive), VP shunt or lumbo-peritoneal shunt. Initial EVD followed by VP shunt has remained the standard for treatment of DH while carrying some possible risks like malfunction, infection, stroke and seizure.…”

Section: Management Of Dhmentioning

confidence: 99%

Outcome of Lumbar Drain in Delayed Communicating Hydrocephalus Secondary to Traumatic and Aneurysmal Subarachnoid Hemorrhage

Roka¹

2020

Nep J Neurosci

View full text Add to dashboard Cite

Introduction: Delayed hydrocephalus is one of the common complications in traumatic subarachnoid hemorrhage and post aneurysmal subarachnoid hemorrhage. This study aims to study the role of lumbar drain in its management. Methods: This is a retrospective study of cases of delayed hydrocephalus which were managed with lumbar drain between March 2009 to February 2019. Computed tomogram or Magnetic Resonance Imaging was used in the diagnosis of delayed hydrocephalus and lumbar drain was inserted. A repeat Computed tomogram scan was performed, and the absence of delayed hydrocephalus was the indication for removal. Results: A total of 40 cases of delayed hydrocephalus were managed with lumbar drain during the study period. Traumatic subarachnoid hemorrhage was the cause of delayed hydrocephalus in 16 cases and the remaining 24 cases were due to post aneurysmal subarachnoid hemorrhage. The most common Fischer grade was III in aneurysm and II in trauma. Delayed hydrocephalus occurred within two to four weeks in aneurysm cases and after four weeks in traumatic cases. All aneurysm was managed with clipping whereas craniotomy or decompressive craniectomy was done in traumatic cases. 92.5% of cases improved after lumbar drainage of the hydrocephalus. Conclusion: This study reports the use of lumbar drain to treat delayed post subarachnoid hemorrhage hydrocephalus in a clinically-cost-effective way with minimal complications. Randomized studies to compare methods to treat delayed hydrocephalus will overcome the limitations of this study. Till then lumbar drain remains a safe alternative in communicating delayed hydrocephalus secondary to subarachnoid hemorrhage.

show abstract

“…Hydrocephalus is a common complication after subarachnoid haemorrhage (SAH), which is characterized by dilated ventricle and increased intracranial pressure [18,25]. The incidence of hydrocephalus in SAH patients is as high as 6-67%, depending on specific background and clinical circumstances [1,12], but most recent studies report an overall 20-30% incidence of hydrocephalus after SAH [9,17].…”

Section: Introductionmentioning

confidence: 99%

The dynamic expression of aquaporins 1 and 4 in rats with hydrocephalus induced by subarachnoid haemorrhage

Long¹,

Huang²,

Du³

et al. 2019

View full text Add to dashboard Cite

Introduction: Hydrocephalus is a common complication of subarachnoid haemorrhage (SAH). As transmembrane water channels, aquaporins 1 and 4 (AQP1 and AQP4) are involved in the pathogenesis of hydrocephalus. We aimed to assess the association between the expressions of AQP1 and AQP4 and the severity and duration of hydrocephalus after SAH. Material and methods: A double haemorrhage model by injection of autologous blood into the cisterna magna was used to induce SAH in rats. Sham rats received the same procedures, but with the injection of normal saline. The SAH group was divided into the SAH with hydrocephalus group and SAH without hydrocephalus group after identifying hydrocephalus histologically. AQP1 and AQP4 in ventricle regions were detected by immunofluorescence, quantitative polymerase chain reaction (qPCR) and western blot. Results: Hydrocephalus was the most severe at day 3 after SAH. AQP1 and AQP4 mRNA and protein levels increased at day 1 and peaked at day 3. The SAH with hydrocephalus group had a higher expression of AQP1 and AQP4 than the SAH without hydrocephalus group. Higher AQP1 levels were found at the apical and basolateral membrane of the choroid plexus epithelium, while higher AQP4 levels were found in the ependymal cells. A positive correlation between the relative lateral ventricle area and the ratio of AQP1/AQP4 proteins was identified. Conclusions: AQP1 and AQP4 are remarkably correlated with the severity of hydrocephalus induced by SAH. AQP1 and AQP4 are potential drug targets for developing therapeutic strategies against hydrocephalus.

show abstract

The Effect of Fenestration of Lamina Terminalis on the Vasospasm and Shunt-Dependent Hydrocephalus in Patients Following Subarachnoid Haemorrhage

Cited by 9 publications

References 23 publications

Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment

Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment

Outcome of Lumbar Drain in Delayed Communicating Hydrocephalus Secondary to Traumatic and Aneurysmal Subarachnoid Hemorrhage

The dynamic expression of aquaporins 1 and 4 in rats with hydrocephalus induced by subarachnoid haemorrhage

Contact Info

Product

Resources

About