The effect of female smoking on in-vitro fertilization outcome

Abstract

Background: to assess the effect of female smoking on in-vitro fertilization (IVF) outcome. Methods: A total of 186 women undergoing IVF treatment cycle at Orient Hospital between December 2020 and December 2021 were classified into two groups smokers and non-smokers (93 patients for each group). An analysis of this prospective cohort study was done , where the outcome involved the following: number of oocytes retrieved, number of Metaphase II oocytes (MII), oocytes quality, maturation rate, fertilization rate, embryos' quality )embryos grade I) and clinical pregnancy rate. Results: the only significant difference was found in the number of grade I embryos which was lower in smokers’ group (p-value= 0.017<0.05) while there was no measurable effect of female smoking on other studied IVF outcomes. Conclusion: Female smoking was associated with decreased quality of embryos (lower number of grade I embryos in smokers’ group) which may affect cumulative pregnancy rate.