The effect of feeding patterns on serum zonulin levels in infants at 3–4 months of age

Kolyva, Soultana; Triga, Maria; Kritikou, Dimitra; Chrysis, Dionisios

doi:10.1007/s00431-021-04102-2

Cited by 4 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the important characteristics during maturation is the decrease in intestinal permeability [21] leading to a difference in uptake of macromolecules and immunoglobulins between or via the intestinal epithelial cells. Importantly, a direct effect of feeding patterns of breast versus formula milk on tight junction functionality via zonulin has not been established [22]. Another striking feature is the enhanced endocytosis capacity of immature intestinal epithelial cells shortly after birth [23], which might give rise to a sensitization of the appropriate immune cells leading to an upregulation of immune markers.…”

Section: Discussionmentioning

confidence: 99%

Baseline Concentrations of Various Immune Biomarkers Determine Their Increase after Consumption of a Postbiotic Based on Cow’s Milk Fermented with Lactobacillus paracasei CBA L74 in Both Newborns and Young Children

Calame¹,

Olderen²,

Calabretta³

et al. 2022

Applied Sciences

View full text Add to dashboard Cite

Intake of a postbiotic product can support immunity depending on specific conditions of the consumer. The present study evaluates the potential impact of baseline values on the change of various immune factors (α-defensin, β-defensin, cathelicidin, and secretory IgA) after three months of consumption of a postbiotic based on cow’s milk fermented with Lactobacillus paracasei CBA L74 in a young population. For the analysis, raw data of three studies were used in a multivariate analysis applying confounding factors. One study in newborns demonstrated that intake of the postbiotic yielded an increase in the concentrations of α-defensin and secretory IgA (at least p < 0.02), while for all factors, except β-defensin, the higher the baseline values the lower the increase (at least p < 0.002). Two combined studies in young children (aged 1–4 years) showed an increase in the concentration of all factors after intake of the postbiotic (at least p < 0.003), but now showing the higher the baseline values the higher the increase after three months (at least p < 0.02) in only the postbiotic group. It is concluded that consumption of the postbiotic leads to a baseline- and age-dependent increase in the concentrations of the immune factors under study in both newborns and young children. It is hypothesized that maturation of the immune system leads to different effects on optimizing host defense factors via this postbiotic intake.

show abstract

Section: Discussionmentioning

confidence: 99%

Baseline Concentrations of Various Immune Biomarkers Determine Their Increase after Consumption of a Postbiotic Based on Cow’s Milk Fermented with Lactobacillus paracasei CBA L74 in Both Newborns and Young Children

Calame¹,

Olderen²,

Calabretta³

et al. 2022

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…increase paracellular flux of macromolecules in mice and humans, but molecular studies are scarce and inconsistent 19 . In conclusion, characteristic structural and functional aspects of the gut epithelial barrier differ between early and adult life 10 .…”

Section: Review Articlementioning

confidence: 99%

Gut–liver axis: barriers and functional circuits

Pabst

Hornef

Schaap

et al. 2023

Nat Rev Gastroenterol Hepatol

View full text Add to dashboard Cite

published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User

show abstract

Programmed and environmental determinants driving neonatal mucosal immune development

Torow¹,

Hand²,

Hornef³

2023

Immunity

View full text Add to dashboard Cite

The effect of feeding patterns on serum zonulin levels in infants at 3–4 months of age

Cited by 4 publications

References 28 publications

Baseline Concentrations of Various Immune Biomarkers Determine Their Increase after Consumption of a Postbiotic Based on Cow’s Milk Fermented with Lactobacillus paracasei CBA L74 in Both Newborns and Young Children

Baseline Concentrations of Various Immune Biomarkers Determine Their Increase after Consumption of a Postbiotic Based on Cow’s Milk Fermented with Lactobacillus paracasei CBA L74 in Both Newborns and Young Children

Gut–liver axis: barriers and functional circuits

Programmed and environmental determinants driving neonatal mucosal immune development

Contact Info

Product

Resources

About