The Effect of Fasting During Ramdan on Endothelial Function

Khouchab, M. A; fihri, Leila Chemaou El; Jourani, S.; Charei, N.; Hattaoui, Mustapha El

doi:10.36347/sasjm.2020.v06i04.004

Cited by 1 publication

(1 citation statement)

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“…Furthermore, it was noted by Gnoni et al (2021) that IF decreased the amount of messenger ribonucleic acid (mRNA) that encodes iNOS in the rat hippocampus. Additionally, Khouchab et al (2020) discovered that prolonged IF enhances both nonendothelial and endothelial microvascular activities.…”

Section: Discussionmentioning

confidence: 99%

Potential role for vitamin D vs. intermittent fasting in controlling aquaporin-1 and aquaporin-3 expression in HFD-induced urinary bladder alterations in rats

Hassan,

El-Gamal,

Hamed

et al. 2024

Front. Mol. Biosci.

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Background: High-fat diet-induced obesity is linked to suppression of aquaporins (AQPs) expression in different tissues. Both vitamin D and intermittent fasting were identified to enhance AQPs expression. In the urinary bladder, AQP-1 and AQP-3 mRNA transcripts were identified. Vitamin D has an impact on a variety of genes that encode proteins that control cell proliferation, differentiation, and death.Aim: To assess potential benefits of vitamin D and intermittent fasting (IF) and to explore alterations to the urinary bladder triggered by high-fat diet (HFD) in a rat model of obesity.Methods: Each of the 4 groups contained six adult male albino rats; control: a standard rodent chew for 12 weeks, HFD: HFD and fructose were administered orally via gastric gavage for 12 weeks, and vitamin D: HFD and fructose were administered orally for 8 weeks, then 4 weeks of intraperitoneal injection of vitamin D (5 microns/Kg/2 days) and IF group: Received intraperitoneal injections of vitamin D (5 microns/Kg/2 days) for 4 weeks after consumption of HFD and fructose orally for 8 weeks. The serum lipid profile was conducted at end of the experiment. In the bladder homogenates, the levels of oxidative stress indicators were assessed. Quantitative real-time PCR was performed on recently collected bladder samples. AQP-1 and AQP-3 immunohistochemistry was done.Results: When compared to the HFD group, the vitamin D and IF groups both demonstrated a substantial improvement in histopathological, immunohistochemical, biochemical, and molecular markers.Conclusion: In all examined parameters, IF exceeded vitamin D as a preventive factor for the urinary bladder deterioration.

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Section: Discussionmentioning

confidence: 99%