Far-infrared ray (FIR) is an electromagnetic wave that produces various health benefits
against pathophysiological conditions, such as diabetes mellitus, renocardiovascular disorders,
stress, and depression etc. However, the therapeutic application on the FIR-mediated protective
potentials remains to be further extended. To achieve better understanding on FIR-mediated therapeutic
potentials, we summarized additional findings in the present study that exposure to FIR ameliorates
stressful condition, memory impairments, drug dependence, and mitochondrial dysfunction
in the central nervous system. In this review, we underlined that FIR requires modulations of janus
kinase 2 / signal transducer and activator of transcription 3 (JAK2/STAT3), nuclear factor E2-
related factor 2 (Nrf-2), muscarinic M1 acetylcholine receptor (M1 mAChR), dopamine D1 receptor,
protein kinase C δ gene, and glutathione peroxidase-1 gene for exerting the protective potentials
in response to neuropsychotoxic conditions.