The effect of far infrared radiation therapy on inflammation regulation in lipopolysaccharide-induced peritonitis in mice

Abstract

Objective:Far infrared radiation has been widely used in a variety of healthcare institutions and clinical research. Previous studies have shown that far infrared radiation can promote blood circulation and enhance the functioning of the immune system. Many patients receiving peritoneal dialysis have been co-treated with far infrared radiation to reduce the occurrence of inflammation. This study seeks to evaluate the effects of far infrared radiation therapy on inflammation.Method:We used the lipopolysaccharide-induced peritonitis mouse model to study the effect of far infrared radiation treatment. Sixteen mice were randomly divided into two groups, a far infrared radiation treatment group (n = 8) and a non-far infrared radiation treatment group (n = 8). Collected blood samples were studied by analyzing the RNA level of peripheral blood mononuclear cells and the plasma protein levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and endothelial nitric oxide synthase (eNOS).Results:The administration of far infrared radiation inhibited the RNA levels of interleukin-6 and TNF-α after stimulation by lipopolysaccharide. The far infrared radiation treatment inhibited the endothelial nitric oxide synthase RNA levels at 1 h, but the RNA levels returned close to the baseline level after 2 h. In the control group, the endothelial nitric oxide synthase RNA levels were continuously decreasing. The interleukin-6 concentration in the plasma of the far infrared radiation group showed significant inhibition 30 min after lipopolysaccharide stimulation. The tumor necrosis factor alpha RNA concentration in plasma of the far infrared radiation group was significantly reduced 2 h after lipopolysaccharide stimulation.Conclusion:Far infrared radiation therapy can inhibit interleukin-6 and tumor necrosis factor alpha RNA levels of peripheral blood mononuclear cells and recover endothelial nitric oxide synthase expression. These results demonstrate that far infrared radiation therapy might aid in reducing the level of inflammation experienced by patients going through peritoneal dialysis treatment.

Far-infrared Ray-mediated Antioxidant Potentials are Important for Attenuating Psychotoxic Disorders

“…Exposure to FIR attenuates TNFα-induced adhesion molecule E-selectin, vascular cell adhesion protein-1, and monocyte chemoattractant protein-1 [55]. Recently, it was reported that exposure to FIR inhibits IL-6 and TNF-α, while activates eNOS expression and vascular endothelial function [56]. In addition, Chen et al (2016) showed that FIRmediated induction of eNOS is essential for improving endothelial function, which is essential for increases in Qa and AVFs [12,55].…”

Far-Infrared-Emitting Sericite Board Upregulates Endothelial Nitric Oxide Synthase Activity through Increasing Biosynthesis of Tetrahydrobiopterin in Endothelial Cells

“…FIR energy in the form of heat is perceived in surrounding tissues by thermoreceptors in the skin [7]. Emerging studies have indicated that FIR therapy improves the health of patients with cardiovascular diseases, diabetes, inflammation, and other diseases [8–11]. However, these studies revealed only that FIR therapy has a protective effect on impaired vascular diseases; the underlying molecular mechanisms of the effects of FIR on eNOS/NO production have not been investigated.…”

Effects of Far-Infrared Therapy on Foot Circulation Among Hemodialysis Patients With Diabetes Mellitus

“…Further, studies investigating nitric oxide synthase (NOS) activity and flap survival of the ischemic dorsum of rats demonstrated that FIR therapy also has a nonthermal biological effect on skin microcirculation (Gribbe et al, 2007). Constitutive NOS is important for basal blood flow in skin (Chang, 2018;Gribbe et al, 2007).…”

“…FIR therapy is known to inhibit vascular inflammation (Chang, 2018;Yu et al, 2006) by inducing hemeoxygenase-1 (HO-1) synthesis (Lin et al, 2008), which leads to increased skin microcirculation and activates and restores endothelial nitric oxide synthase (eNOS; Gribbe et al, 2007;Yu et al, 2006), which regulates vascular tone and permeability. The therapy also inhibits interleukin (IL) 6 and tumor necrosis factor (TNF) a response to reduce vessel inflammation and increase angiogenesis (Lin et al, 2008).…”

“…FIR enhances the capacity of vascular endothelial cells to form tubules, strengthens angiogenesis and the combining of hemoglobin and oxygen, and increases the blood oxygen content and microcirculation of the skin surface through NO epidermal microcirculation (Fraislm et al, 2009). Evidence further suggests that FIR inhibits vessel endothelium growth, reduces vessel sclerosis associated with oxidative stress, and improves vessel repair effects (Chang, 2018;Choi et al, 2016;Lin et al, 2016). Such therapy may thus improve vessel dilation and/or circulation, vessel endothelial function, and angiogenesis (Chen, Lee, et al, 2016;Chen, Yang, et al, 2016;Lo et al, 2019;Yu et al, 2006).…”