The Effect of Famotidine on Hospitalized Patients with COVID-19: a Systematic Review and Meta-analysis

Abstract

Introduction: Famotidine is a competitive histamine H2-receptor antagonist most commonly used for gastric acid suppression but thought to have potential efficacy in treating patients with COVID-19. The aims of this systematic review and meta-analysis are to summarize the current literature and report clinical outcomes on the use of famotidine for treatment of hospitalized patients with COVID-19. Methods: Five databases were searched through February 12, 2021 to identify observational studies that reported on associations of famotidine use with outcomes in COVID-19. Meta-analysis was conducted for composite primary clinical outcome (e.g. rate of death, intubation, or intensive care unit admissions) and death separately, where either aggregate odds ratio (OR) or hazard ratio (HR) was calculated. Results: Four studies, reporting on 46,435 total patients and 3,110 patients treated with famotidine, were included in this meta-analysis. There was no significant association between famotidine use and composite outcomes in patients with COVID-19: HR 0.63 (95% CI: 0.35, 1.16). Across the three studies that reported mortality separated from other endpoints, there was no association between famotidine use during hospitalization and risk of death - HR 0.67 (95% CI: 0.26, 1.73) and OR 0.79 (95% CI: 0.19, 3.34). Heterogeneity ranged from 83.69% to 88.07%. Conclusion: Based on the existing observational studies, famotidine use is not associated with a reduced risk of mortality or combined outcome of mortality, intubation, and/or intensive care services in hospitalized individuals with COVID-19, though heterogeneity was high, and point estimates suggested a possible protective effect for the composite outcome that may not have been observed due to lack of power. Further RCTs may help determine the efficacy and safety of famotidine as a treatment for COVID-19 patients in various care settings of the disease

Association between histamine 2 receptor antagonists and sepsis outcomes in ICU patients: a retrospective analysis using the MIMI-IV database

“…Other purported extraintestinal benefits of H2RAs are far-reaching and include reduction of bladder pain from interstitial cystitis, improvement of cell-mediated immunity, and reduction of symptoms related to erythropoietic protoporphyria [42][43][44]. Furthermore, recent studies have demonstrated a potential role for H2RAs as an adjunctive treatment for COVID-19 [45,46]. To the best of our knowledge, this is the first large-scale study to assess the effect of H2RAs on mortality in the setting of sepsis.…”

Survival analysis based on body mass index in patients with Covid-19 admitted to the intensive care unit of Amir Al-Momenin Hospital in Arak – 2021

“…However, in a meta-analysis of observational study famotidine has been shown is not associated with a reduced risk of mortality, intubation, and/or ICU admission in COVID-19 patients, but the heterogeneity of studies was high, and due to lack of power a possible protective effect has been proposed ( Chiu et al, 2021 ). On the other hand, in a randomized, double-blind, clinical trial famotidine has been shown that lead to earlier resolution of covid-19 symptoms and inflammation ( Brennan et al, 2022 ).…”