The Effect of Extremely Hot Baths in Experimental Syphilis

Fever therapy for general paresis

“…The method by which malaria and other forms of induced fever had an apparently beneficial effect in general paresis was a matter of great interest, but always remained speculative and controversial. Jay Frank Schamberg (1870–1934), a pioneer of syphilis chemotherapy, performed experimental work on the inhibitory effects of fever on syphilis in rabbits, but considered the action of fever therapy to be “shrouded in obscurity.” 36 Others conducted studies of the thermal death time of Treponema pallidum , which suggested it was thermolabile, and proposed this as the basis of fever’s therapeutic effect. 37 Some advocates of malaria therapy, including Wagner‐Jauregg, believed that plasmoidal infection produced additional poorly‐defined stimulation of the immune system, besides fever, which made it superior to “artificial fever.” 38…”

Review of Experimental Research in Syphilis and Its Possible Application to Man

“…The effect of raising a rabbit's temperature on the development of syphilitic lesions after inoculation has been investigated by Schamberg and Rule (I926 and I928). 59 The method of raising the temperature which was chiefly employed was to put the animals into hot baths at II3°F. for fifteen to twenty minutes daily.…”