The Effect of Extracellular Vesicles on Thrombosis

He, Youfu; Wu, Qiang

doi:10.1007/s12265-022-10342-w

Cited by 9 publications

(7 citation statements)

References 148 publications

(174 reference statements)

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“…Recent studies have documented that EVs released by cancer cells could promote a pro-coagulant shift on endothelium, which expresses Tissue Factor (TF) and thrombin. Moreover, it has been demonstrated that cancer cells release TF-enriched EVs, which activate platelets and favor their aggregation [ 48 ]. Lastly, we must report that the thrombotic risk of chemotherapy and other cancer treatments has still to be addressed.…”

Section: Discussionmentioning

confidence: 99%

The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review

Laurino,

Russi,

Omer

et al. 2024

Diseases

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The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial thromboembolism (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent useful hints for a comprehensive review of the thrombotic issue. A 75-year-old man with advanced rectal cancer treated with fluoropyrimidines suffered two catheter-related VTE events managed according to current guidelines. There was no indication for “extended” anticoagulant therapy for him, but during antithrombotic wash-out and fluoropyrimidines plus panitumumab regimen, he suffered a massive right coronary artery (RCA) thrombosis. Another patient with no cardiovascular (CV) risk factors and affected by advanced bladder cancer was treated with a platinum-containing regimen and suffered an acute inferior myocardial infarction 2 days after chemotherapy administration. He was successfully treated with primary Percutaneous Transluminal Coronary Angioplasty of RCA, discontinuing platinum-based therapy. Our observations raise the issue of cancer-associated thrombosis (CAT) complexity and the potential correlation between arterial and venous thrombotic events. Moreover, physicians should be aware of the thrombotic risk associated with anticancer therapies, suggesting that an appropriate prophylaxis should be considered.

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Section: Discussionmentioning

confidence: 99%

The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review

Laurino,

Russi,

Omer

et al. 2024

Diseases

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show abstract

“…Their abundance in the bloodstream and pivotal roles in processes such as wound healing, angiogenesis, thrombosis, and atherosclerosis make them a significant focus of study [ 201 , 202 , 203 , 204 ]. The isolation of these EVs, which requires further study, could aid the understanding and treatment of a variety of clotting disorders and thrombocytopenias [ 205 ]. Red blood cell-derived EVs (RBC-EVs) have also attracted attention due to their potential role in erythropoiesis, iron homeostasis, and hemolysis.…”

Section: Cts-evs In Physiology and Pathologymentioning

confidence: 99%

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Amin,

Massoumi,

Tewari

et al. 2024

IJMS

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Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal in mediating intercellular communication due to their ability to selectively transfer biomolecules to specific cell types. EVs, composed of proteins, nucleic acids, and lipids, are taken up by cells to affect a variety of signaling cascades. Research in the field has primarily focused on stem cell-derived EVs, with a particular focus on mesenchymal stem cells, for their potential therapeutic benefits. Recently, tissue-specific EVs or cell type-specific extracellular vesicles (CTS-EVs), have garnered attention for their unique biogenesis and molecular composition because they enable highly targeted cell-specific communication. Various studies have outlined the roles that CTS-EVs play in the signaling for physiological function and the maintenance of homeostasis, including immune modulation, tissue regeneration, and organ development. These properties are also exploited for disease propagation, such as in cancer, neurological disorders, infectious diseases, autoimmune conditions, and more. The insights gained from analyzing CTS-EVs in different biological roles not only enhance our understanding of intercellular signaling and disease pathogenesis but also open new avenues for innovative diagnostic biomarkers and therapeutic targets for a wide spectrum of medical conditions. This review comprehensively outlines the current understanding of CTS-EV origins, function within normal physiology, and implications in diseased states.

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“…Recent technological advances, particularly in electron microscopy, have supported growing interest in extracellular vesicles (EVs), small cell-derived particles whose role extends beyond intercellular communication. These lipid bilayer structures play a critical role in physiological and pathological processes, including immune response, cancer metastasis [ 80 ], endothelial dysfunction and thrombosis [ 81 ]. Extracellular vesicles, which are classified according to their size, density and centrifugation speed [ 82 , 83 , 84 ], are divided into three main types.…”

Section: Role Of Extracellular Vesicles In Thrombosismentioning

confidence: 99%

“…The release of EVs is not restricted to specific cell types, and surface antigens reflect their cellular origin, facilitating detection by flow cytometry. The surface markers for different EVs according to their origin are listed in Table 2 [ 81 , 89 , 90 ]. Platelet-derived EVs are the most common, followed by those from endothelial cells, granulocytes and erythrocytes [ 91 , 92 ].…”

Section: Role Of Extracellular Vesicles In Thrombosismentioning

confidence: 99%

Research into New Molecular Mechanisms in Thrombotic Diseases Paves the Way for Innovative Therapeutic Approaches

Sacchetti,

Puricelli,

Mennuni

et al. 2024

IJMS

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Thrombosis is a multifaceted process involving various molecular components, including the coagulation cascade, platelet activation, platelet–endothelial interaction, anticoagulant signaling pathways, inflammatory mediators, genetic factors and the involvement of various cells such as endothelial cells, platelets and leukocytes. A comprehensive understanding of the molecular signaling pathways and cell interactions that play a role in thrombosis is essential for the development of precise therapeutic strategies for the treatment and prevention of thrombotic diseases. Ongoing research in this field is constantly uncovering new molecular players and pathways that offer opportunities for more precise interventions in the clinical setting. These molecular insights into thrombosis form the basis for the development of targeted therapeutic approaches for the treatment and prevention of thrombotic disease. The aim of this review is to provide an overview of the pathogenesis of thrombosis and to explore new therapeutic options.

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The Effect of Extracellular Vesicles on Thrombosis

Cited by 9 publications

References 148 publications

The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review

The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Research into New Molecular Mechanisms in Thrombotic Diseases Paves the Way for Innovative Therapeutic Approaches

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