The effect of exposure to hypoxia on superoxide formation by alveolar macrophages is indirect

Žaloudíková, Marie; Vytášek, Richard; Rašková, Marcela; Vízek, M; Uhlı́k, Jir̆ı́; Hampl, Václav

doi:10.1016/j.lfs.2019.116864

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Endothelial dysfunction and environmental stress induce metabolic alterations and proliferation in pulmonary VSMCs and fibroblasts. Moreover, perivascular inflammatory infiltration and circular cytokine alterations can be detected in the early stage of PH, suggesting that the immune system responds to microenvironmental changes and external stimuli even before substantial vascular remodelling occurs [ 17 , 119 ]. These changes interact with other PH promotors.…”

Section: Introductionmentioning

confidence: 99%

Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension

Zuo,

Li,

Gao

et al. 2024

Respir Res

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Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically activated M1 macrophages and alternatively activated M2 macrophages, are both involved in inflammatory processes related to pulmonary hypertension. Recent advances suggest that macrophages coordinate interactions among different proinflammatory and anti-inflammatory mediators, and other cellular components such as smooth muscle cells and fibroblasts. In this review, we summarize the current literature on the role of macrophages in the pathogenesis of pulmonary hypertension, including the origin of pulmonary macrophages and their response to triggers of pulmonary hypertension. We then discuss the interactions among macrophages, cytokines, and vascular adventitial fibroblasts in pulmonary hypertension, as well as the potential therapeutic benefits of macrophages in this disease. Identifying the critical role of macrophages in pulmonary hypertension will contribute to a comprehensive understanding of this pathophysiological abnormality, and may provide new perspectives for pulmonary hypertension management.

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Section: Introductionmentioning

confidence: 99%

Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension

Zuo,

Li,

Gao

et al. 2024

Respir Res

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Simvastatin and dehydroepiandrosterone sulfate effects against hypoxic pulmonary hypertension are not additive

Krása

Vajnerová²,

Ova³

et al. 2022

Physiol Res

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Pulmonary hypertension is a group of disorders characterized by elevated mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance. To test our hypothesis that combining two drugs useful in experimental pulmonary hypertension, statins and dehydroepiandrosterone sulfate (DHEA S), is more effective than either agent alone, we induced pulmonary hypertension in adult male rats by exposing them to hypoxia (10%O2) for 3 weeks. We treated them with simvastatin (60 mg/l) and DHEA S (100 mg/l) in drinking water, either alone or in combination. Both simvastatin and DHEA S reduced mPAP (froma mean±s.d. of 34.4±4.4 to 27.6±5.9 and 26.7±4.8 mmHg, respectively), yet their combination was not more effective (26.7±7.9 mmHg). Differences in the degree of oxidative stress (indicated by malondialdehydeplasma concentration),the rate of superoxide production (electron paramagnetic resonance), or blood nitric oxide levels (chemiluminescence) did not explain the lack of additivity of the effect of DHEA S and simvastatin on pulmonary hypertension. We propose that the main mechanism of both drugs on pulmonary hypertension could be their inhibitory effect on 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, which could explain their lack of additivity.

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Mechanisms and Effects of Macrophage Polarization and Its Specifics in Pulmonary Environment

Žaloudíková

2023

Physiol Res

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Macrophages are a specific group of cells found in all body tissues. They have specific characteristics in each of the tissues that correspond to the functional needs of the specific environment. These cells are involved in a wide range of processes, both pro-inflammatory and anti-inflammatory (“wound healing”). This is due to their specific capacity for so-called polarization, a phenotypic change that is, moreover, partially reversible compared to other differentiated cells of the human body. This promises a wide range of possibilities for its influence and thus therapeutic use. In this article, we therefore review the mechanisms that cause polarization, the basic classification of polarized macrophages, their characteristic markers and the effects that accompany these phenotypic changes. Since the study of pulmonary (and among them mainly alveolar) macrophages is currently the focus of scientific interest of many researchers and these macrophages are found in very specific environments, given mainly by the extremely high partial pressure of oxygen compared to other locations, which specifically affects their behavior, we will focus our review on this group.

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The effect of exposure to hypoxia on superoxide formation by alveolar macrophages is indirect

Cited by 3 publications

References 23 publications

Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension

Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension

Simvastatin and dehydroepiandrosterone sulfate effects against hypoxic pulmonary hypertension are not additive

Mechanisms and Effects of Macrophage Polarization and Its Specifics in Pulmonary Environment

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