The Effect of Experimental Renal Failure on Tolfenamic Acid Disposition in the Dog

Pharmacokinetics of tolfenamic acid in goats after different administration routes

“…In this study, the V dss following IV administration of tolfenamic acid at a dose of 2 mg/kg in goats was low with 0.37 L/kg, which was similar to that previously reported in goats, sheep, and horses (0.32–0.42 L/kg, Corum et al, 2018; Jaussaud et al, 1992; Tekeli et al, 2020) and lower than that reported in camels (0.68 L/kg, Wasfi et al, 1998), dogs and calves (0.98–1.79 L/kg, Landoni et al, 1996; Lefebvre et al, 1997). The binding ratio of drugs to plasma proteins and the body composition affect the distribution volume (Sakai, 2009).…”

“…In this study, Cl T following IV administration of tolfenamic acid in goat was 0.27 L/h/kg, which was similar to that previously reported in goats, sheep, and calves (0.26-0.30 L/h/kg, Corum et al, 2018;Landoni et al, 1996;Tekeli et al, 2020) and was greater than that reported in camels, horses, and dogs (0.07-0.13 L/h/kg, Jaussaud et al, 1992;Lefebvre et al, 1997;Wasfi et al, 1998).…”

Pharmacokinetics of tolfenamic acid after different administration routes in geese (Anser cygnoides)

“…Because the t 1/2ʎz is a hybrid parameter consisting Cl T and V d (Toutain & Bousquet-Melou, 2004), the different t 1/2ʎz of tolfenamic acid among species reflects the difference in Cl T and V d . In this study, the V dss of tolfenamic acid was 0.25 L/kg, which was similar to that previously reported in goat, sheep, horse, and red-eared slider turtles (0.30-0.41 L/kg, Corum et al, 2018;Corum et al, 2019;Jaussaud et al, 1992;Tekeli et al, 2020), lower than that previously reported in camel and dog (0.68-1.1 L/kg, Lefebvre et al, 1997;Wasfi et al, 1998), and higher than TA B L E 1 Plasma pharmacokinetic parameters of tolfenamic acid following intravenous (IV), intramuscular (IM), subcutaneous (SC) and oral (PO) administrations at a dose of 2 mg/kg in geese (n = 8) Note: Data were presented as the geometric mean (range), except for T max , which is displayed as median (range).…”

“…Because the t 1/2ʎz is a hybrid parameter consisting Cl T and V d (Toutain & Bousquet‐Melou, 2004), the different t 1/2ʎz of tolfenamic acid among species reflects the difference in Cl T and V d . In this study, the V dss of tolfenamic acid was 0.25 L/kg, which was similar to that previously reported in goat, sheep, horse, and red‐eared slider turtles (0.30–0.41 L/kg, Corum et al, 2018; Corum et al, 2019; Jaussaud et al, 1992; Tekeli et al, 2020), lower than that previously reported in camel and dog (0.68–1.1 L/kg, Lefebvre et al, 1997; Wasfi et al, 1998), and higher than that in green sea turtles and Hawksbill turtles (0.03–0.05 L/kg, Raweewan, Chomcheun, et al, 2020; Raweewan, Laovechprasit, et al, 2020). In general, NSAIDs are highly bound to plasma proteins; therefore, their distribution volumes are low (Landoni et al, 1996).…”

Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy

“…The results of this study demonstrate that plasma exogenous creatinine clearance is an accurate indicator of GFR in healthy dogs and dogs with a 60% decrease in GFR over a creatinine dosage range of 40-160 mg/kg. Previous values observed in healthy dogs for clearance of endogenous creatinine (3.7 Ϯ 0.77 mL/kg/min), 14 plasma iothalamate (2.9 Ϯ 0.26 mL/kg/min), 2 plasma inulin (4.4 Ϯ 1.15 mL/ kg/min), 15 and urine inulin (2.8 mL/kg/min) 16 are similar to those observed in the dogs of this study. Mean recovery of exogenous creatinine in canine urine was about 99% (similar to values previously published), 17 indicating that extrarenal elimination of creatinine is negligible.…”