The effect of exogenous thyroid hormones on functional recovery of the rat after acute spinal cord compression injury

Tator, Charles H.; Jagt, Richard H. C. Van Der

doi:10.3171/jns.1980.53.3.0381

Cited by 16 publications

(3 citation statements)

References 19 publications

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“…17 In 1967, Harvey and Srebnik 12 reported that L-thyroxine improved the recovery of rats after crush injuries of the spinal cord, and in our laboratory it was recently shown that thyroid hormones produced Effect of T3 on axonal regeneration in spinal a slightly improved recovery in rats subjected to an acute cord compression injury. 35 The present experiment was undertaken to further assess the clinical and histological effects of triiodo-Lthyronine (T3) in spinal cord-injured rats. Clinical assessment was made by the inclined-plane technique, 29 and histological assessment was performed by counting axons in the pyramidal tract proximal and distal to the site of injury, a technique recently developed in our laboratory.…”

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confidence: 99%

Effect of triiodo-L-thyronine on axonal regeneration in the rat spinal cord after acute compression injury

Tator¹,

Rivlin²,

Lewis³

et al. 1983

Journal of Neurosurgery

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Studies were performed on the effect of triiodo-L-thyronine (T3) on clinical recovery and axonal counts in the pyramidal tract of 56 rats subjected to an acute spinal cord compression injury at T-7. The T3 was given at a daily dose of 5 micrograms/kg for 4 weeks to 28 rats in the treatment group. The treatment and control animals were tested weekly for clinical recovery, and cord function as determined by the inclined-plane technique. Groups of animals were killed at 4 weeks and 12 weeks, and the axons in the pyramidal tract cephalad and caudad to the injury site were counted in sections prepared with Holmes' silver stain. There was no difference in clinical recovery between the treatment and control groups. This negative result contrasts with other studies which showed improved recovery of cord-injured animals treated with thyroid hormones. The possible explanations for this discrepancy are discussed. Similarly, there was no difference in the axon counts between the treated and control groups. Thus, T3 did not improve recovery or axonal regeneration in the pyramidal tract of rats after acute spinal cord compression injury. Between 4 and 12 weeks, there was a marked reduction in the cephalad axon counts in the pyramidal tract in both groups, indicating that approximately 50% of the axons in the pyramidal tract had undergone retrograde degeneration or dying back by 12 weeks after this degree of injury. The T3 did not affect the degree of retrograde degeneration.

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confidence: 99%

Effect of triiodo-L-thyronine on axonal regeneration in the rat spinal cord after acute compression injury

Tator¹,

Rivlin²,

Lewis³

et al. 1983

Journal of Neurosurgery

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“…The effects of GH are focused on minimizing protein loss through oxidation and increasing body and muscle mass [13]. Furthermore, GH plays an important paracrine effect on the central nervous system [14], where thyroid-stimulating hormone (TSH) is also implicated in the normal development of the nervous system, too [14][15][16][17][18]. The role of GH in the adult nervous system is controversial, but it has been reported to exert neuroprotective and neuroreparative functions [7,8].…”

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confidence: 99%

Effects of Growth Hormone Treatment and Rehabilitation in Incomplete Chronic Traumatic Spinal Cord Injury: Insight from Proteome Analysis

Martín-Rojas

Sastre-Oliva

Esclarín-Ruz

et al. 2020

JPM

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Despite promising advances in the medical management of spinal cord injury (SCI), there is still no available effective therapy to repair the neurological damage in patients who experience this life-transforming condition. Recently, we performed a phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone (GH) treatment in incomplete chronic traumatic spinal cord injury. The main findings were that the combined treatment of GH plus rehabilitation treatment is feasible and safe, and that GH but not placebo slightly improves the SCI individual motor score. Moreover, we found that an intensive and long-lasting rehabilitation program per se increases the functional outcome of SCI individuals. To understand the possible mechanisms of the improvement due to GH treatment (motor score) and due to rehabilitation (functional outcome), we used a proteomic approach. Here, we used a multiple proteomic strategy to search for recovery biomarkers in blood plasma with the potential to predict response to somatropin treatment and to delayed intensive rehabilitation. Forty-six patients were recruited and followed for a minimum period of 1 year. Patients were classified into two groups based on their treatment: recombinant somatropin (0.4 mg) or placebo. Both groups received rehabilitation treatment. Our strategy allowed us to perform one of the deepest plasma proteomic analyses thus far, which revealed two proteomic signatures with predictive value: (i) response to recombinant somatropin treatment and (ii) response to rehabilitation. The proteins implicated in these signatures are related to homeostasis, inflammation, and coagulation functions. These findings open novel possibilities to assess and therapeutically manage patients with SCI, which could have a positive impact on their clinical response.

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“…4 The depression in T4 persisted for 3 days but the levels of TSH showed significant recovery within 24 hours. When these re sults were compared with those of a control group of rats subjected to laminectomy without cord injury, the depression in T4 was found to be greater in the spinal cord injury group than in the laminectomy group alone.…”

Section: Introductionmentioning

confidence: 99%

Changes in thyroid hormones, thyroid stimulating hormone and cortisol in acute spinal cord injury

et al. 1992

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To determine the hormonal response to acute spinal cord injury, serial serum samples were collected from 18 patients with acute spinal cord injury and from 14 control patients with spinal fractures without cord injury. The first sample was taken within 24 hours of injury, the second at 24-48 hours; and the third at 7 days for determination of thyroxine (T4), free T4 (FT4) , triiodothyronine (T3), reverse T3 (rT3), T3 uptake (T3U), thyroid stimulating hormone (TSH), thyroxine binding globulin (TBG), growth hormone (GH), cortisol, and insulin. Significant increases were observed in rT3 levels and transient changes were observed in the T4 and T3 levels in the spinal cord injured group but not in the group with spinal fractures alone. The changes in the spinal cord injured patients are consistent with the 'low T3 syndrome'. However, the persisting rise of rT3 at 7 days was an unexpected finding. In addition to the cord injury, these changes may also be related to dexamthasone administration and nutritional factors.

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The effect of exogenous thyroid hormones on functional recovery of the rat after acute spinal cord compression injury

Cited by 16 publications

References 19 publications

Effect of triiodo-L-thyronine on axonal regeneration in the rat spinal cord after acute compression injury

Effect of triiodo-L-thyronine on axonal regeneration in the rat spinal cord after acute compression injury

Effects of Growth Hormone Treatment and Rehabilitation in Incomplete Chronic Traumatic Spinal Cord Injury: Insight from Proteome Analysis

Changes in thyroid hormones, thyroid stimulating hormone and cortisol in acute spinal cord injury

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