The effect of exhaustive exercise on expired pentane as a measure of in vivo lipid peroxidation in the rat

Gee, David L.; Tappel, Al L.

doi:10.1016/0024-3205(81)90510-5

Cited by 59 publications

(14 citation statements)

References 11 publications

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“…(26,31,32,(40)(41)(42)(43)(44) We predicted that, with training, the body can and does adapt to this kind of stress. Our results show that training induces changes in the body's biochemistry such that cellular glutathione redox status is maintained even under conditions of moderate submaximal exercise.…”

Section: Discussionmentioning

confidence: 99%

Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification

Lew

Quintanilha

1991

European Journal of Drug Metabolism and Pharmacokinetics

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Both acute acetaminophen toxicity and physical exercise are accompanied by structural and functional damage to tissues. For acute acetaminophen toxicity, this damage occurs mainly in the liver. This damage, which is believed to be initially caused by oxidation and/or arylation, occurs only after depletion of liver glutathione (GSH). GSH normally protects against oxidation and/or arylation. Prolonged physical exercise also depletes GSH in the body. We hypothesized that with endurance training (repeated oxidant stress) tissues will develop mechanisms to prevent GSH depletion. Our results show that, for the same amount of submaximal exercise, trained rats are able to maintain their levels of GSH or their GSH redox status (in the liver, heart, skeletal muscle and plasma) in contrast to their untrained counterparts. Also, upon administration of acetaminophen, trained rats show a less pronounced depletion in liver GSH than untrained rats. We also hypothesized that training may lead to improved maintenance of tissue GSH homeostasis because of induction in the enzyme pathways of protection. We observe that training significantly increases (50-70%) glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase, and catalase activity in heart and skeletal muscle. Since GSH, in addition to providing cellular protection, also functions in other physiological processes including transport and metabolism, the training-induced benefits seen here may have more far-reaching consequences than ever before realized.

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Section: Discussionmentioning

confidence: 99%

Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification

Lew

Quintanilha

1991

European Journal of Drug Metabolism and Pharmacokinetics

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“…Several papers have recently reported increased levels of LIPOX (defined as thiobarbituric acid reactive substances, TBARS) in erythrocytes of horses (1) and in skeletal muscle and liver of rats (2) after an exhaustive exercise. In addition, expired pentane, which is thought as a peroxidation product from w-6 series of fatty acids, was reported to be increased in man during bicycle ergometer exercise (3) and in rats after a bout of exhaustive swimming exercise (4). On the other hand, a moderate swimming exercise training for several weeks has been reported to reduce plasma and liver LIPOX contents in rats (5 with free access to water.…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced enhancement of lipid peroxide metabolism in tissues and their transference into the brain in rat.

Suzuki

Katamine

Tatsumi

1983

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThis study was conducted to investigate whether a moderate running exercise would enhance or prevent the lipid peroxidation in animal body and also stimulate or depress the degradation-excretion of lipid peroxides (LIPOX, thiobarbituric acid reactive substances deter mined as malon dialdehyde) in young female rats. Compared with sedentary rats, voluntary wheel-running exercised rats did not show any significant difference in total LIPOX contents in plasma and several tissues including brain, and whole body during 4 weeks of experiment with a vitamin E-free low LIPOX diet. On the contrary, when rats were previously fed a high LIPOX diet and then allowed voluntary exercise with a vitamin E-added low LIPOX diet, total LIPOX contents per whole body reduced significantly faster in the exercised rats than in the sedentary controls during 2 weeks of exercise. At that period, LIPOX were progressively increased in the brain in both groups of animals, but was significantly greater in the exercised group. Interestingly, more than 80% of total LIPOX contents in whole body were found to be stored in carcass portions regardless of greater or lesser amounts of LIPOX contents in rats. These data suggest that a moderate exercise of several weeks might enhance the degradation-excretion of LIPOX but not the formation accumulation of LIPOX in rats. Exercise also seems to modulate LIPOX transference among tissues.

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“…Under exercise conditions that lead to fatigue, the concentration of lipid peroxide in the liver or muscles increase, and the pentane content in expiration enhances [28][29][30]. The anti-oxidative effects of garlic have been reported to include enhancement of superoxide dismutase activity [31], a decrease of the serum lipid peroxide level [32], and trapping of hydroxyl radicals [33].…”

Section: Anti-oxidative Effectsmentioning

confidence: 95%

Garlic as an anti‐fatigue agent

Morihara¹,

Nishihama

Ushijima

et al. 2007

Molecular Nutrition Food Res

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More than three thousand publications in the past have confirmed the efficacy of garlic for the prevention and treatment of a variety of diseases, acknowledging and validating its traditional uses. Garlic is also used for the treatment of fatigue, although the mechanism involved remain unclear. The anti-fatigue function of garlic may be closely related to its many favorable biological and pharmacological effects. In animal studies, garlic has been shown to promote exercise endurance. Differences in the methods of processing garlic result in differences in the intensity of its anti-fatigue effect, and the most favorable form of processing has been shown to be extraction of raw garlic followed by its natural aging for a long period in a water-ethanol mixture. In human studies, it has been confirmed that garlic produces symptomatic improvement in persons with physical fatigue, systemic fatigue due to cold, or lassitude of indefinite cause, suggesting that garlic can resolve fatigue through a variety of actions. Recently, primarily in Japan, attempts have been made to measure the intensity of fatigue objectively and quantitatively using biomarkers. Currently available data strongly suggest that garlic may be a promising anti-fatigue agent, and that further studies to elucidate its application are warranted.

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The effect of exhaustive exercise on expired pentane as a measure of in vivo lipid peroxidation in the rat

Cited by 59 publications

References 11 publications

Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification

Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification

Exercise-induced enhancement of lipid peroxide metabolism in tissues and their transference into the brain in rat.

Garlic as an anti‐fatigue agent

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