The effect of exhalation before the inhalation of dry powder aerosol drugs on the breathing parameters, emitted doses and aerosol size distributions

The effect of lung emptying before the inhalation of aerosol drugs on drug deposition in the respiratory system

“…As highlighted by the above statements, the change in lung dose at different levels of lung emptying, compared to the case of no emptying, is device- and formulation-specific. Although deep exhalation caused the increase of inhalation volume, inhaled flow rate and inhalation time for all the studied inhalers ( Farkas et al, 2023 ), the average value of the relative change of lung dose could be negative, slightly negative, slightly positive, and also positive. In order to explain this large variability of the results an in-depth analysis of the dependence of lung deposition on different parameters was performed.…”

“…The measurement of breathing parameters when inhaling through different inhalers was the subject of a previous publication ( Farkas et al, 2023 ), thus it will not be repeated here. However, the salient features of the study will be briefly recalled for the sake of the reader.…”

BDP/FF NEXThaler to Improve Asthma Control Status in the Real World: The NEWTON Study

“…22 BDP/FF DPI is also relatively insensitive to improper use as double activation, accidental fall, activation at different degrees of inclination, exhalation inside the device, 23 and incorrect exhalation before the inhalation. 24…”

Légzési paraméterek hatása az inhalációs gyógyszerek tüdőbeli kiülepedésére

“…A finomrészecske frakció Foster Nexthaler® esetében 1,9%-os, míg Symbicort Turbuheler® esetén 30,8%-os növekedést mutat. 2 Mindezeknek a légzési paraméterek változásával együtt befolyása van a tüdődepozícióra is. A betegek egy jelentős részénél eszközfüggően növekszik a depozíció, melynek átlagos mértéke 7,1% (Seebri Breezhaler®) -31,8% (Symbicort Turbuhaler®) között van.…”