The effect of exercise on anxiety- and depression-like behavior of aged rats

Gökdemir, Özden; Çetinkaya, Caner; Gümüş, Hikmet; Aksu, İlkay; Kıray, Müge; Ateş, Mehmet; Kiray, A.; Baykara, Burak; Baykara, Başak; Şişman, Ali Rιza; Uysal, Nazan

doi:10.1080/10520295.2019.1624825

Cited by 16 publications

(14 citation statements)

References 57 publications

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“…Our results confirmed the previous report of Singhal et al [ 22 ] suggesting that aging is not related to an increase in depressive-like responses in mice. However, other authors have reported opposite results for depressive patterns measured in the forced swimming test (FST) in female rats [ 23 , 24 , 25 ]. If the animals have decreased locomotion, depressive-like behavior measured in the FST could give false-positive results.…”

Section: Discussionmentioning

confidence: 99%

Impact of Melatonin Deficit on Emotional Status and Oxidative Stress-Induced Changes in Sphingomyelin and Cholesterol Level in Young Adult, Mature, and Aged Rats

Tchekalarova

Nenchovska

Kortenska

et al. 2022

IJMS

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The pineal gland regulates the aging process via the hormone melatonin. The present report aims to evaluate the effect of pinealectomy (pin) on behavioral and oxidative stress-induced alterations in cholesterol and sphingomyelin (SM) levels in young adult, mature and aging rats. Sham and pin rats aged 3, 14 and 18 months were tested in behavioral tests for motor activity, anxiety, and depression. The ELISA test explored oxidative stress parameters and SM in the hippocampus, while total cholesterol was measured in serum via a commercial autoanalyzer. Mature and aged sham rats showed low motor activity and increased anxiety compared to the youngest rats. Pinealectomy affected emotional responses, induced depressive-like behavior, and elevated cholesterol levels in the youngest rats. However, removal of the pineal gland enhanced oxidative stress by diminishing antioxidant capacity and increasing the MDA level, and decreased SM level in the hippocampus of 14-month-old rats. Our findings suggest that young adult rats are vulnerable to emotional disturbance and changes in cholesterol levels resulting from melatonin deficiency. In contrast, mature rats with pinealectomy are exposed to an oxidative stress-induced decrease in SM levels in the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Impact of Melatonin Deficit on Emotional Status and Oxidative Stress-Induced Changes in Sphingomyelin and Cholesterol Level in Young Adult, Mature, and Aged Rats

Tchekalarova

Nenchovska

Kortenska

et al. 2022

IJMS

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“…In a sleep deprivation-induced depression mouse model, exercise was also found to normalize the decreased levels of BDNF, and therefore exert neuroprotective effect and neurotrophic effect ( 52 ). In addition, study demonstrated exercise pretreatment could prevent depressive behavior and neurochemical alterations, such as increased levels of norepinephrine (NE), serotonin and its metabolite in the mouse brain, associated with sleep deprivation ( 42 , 44 ). Furthermore, in a maternal separation-induced depression animal model, the level of 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) were decreased in the dorsal raphe.…”

Section: Effects and Mechanisms Of Exercise On Depressionmentioning

confidence: 99%

Beneficial Effects of Exercise on Depression and Anxiety During the Covid-19 Pandemic: A Narrative Review

Tucker

et al. 2020

Front. Psychiatry

103

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First reported in Dec 2019, the on-going COVID-19 pandemic has become a public health emergency of international concern (PHEIC). The isolation and quarantine during the COVID-19 pandemic limited the physical and social activities of the population, which contributed to the increased prevalence of mental disorder. Depression and anxiety are the most common mental illnesses conferring a serious impact on individuals' life quality. This review summarizes the mental health consequences of COVID-19, especially for depression and anxiety. Exercise as an intervention for anxiety and depression has been demonstrated in both of the animal studies and human clinical trials. The underlying mechanism including the regulation on the production of brain-derived neurotrophic factor (BDNF), D-β-hydroxybutyrate, synaptic transmission, hypothalamic pituitary adrenal (HPA) axis, tryptophan hydroxylase, GSK3β/β-catenin pathway, neuroinflammation, oxidative stress and PGC-1α1-PPAR axis. In addition, we summarized the exercise strategies to fight against anxiety and depression according to the information from American College of Sports Medicine (ACSM), World Health Organization and recent literatures about physical exercise during COVID-19.

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“…Despite this benefit, though other well-documented outcomes reflecting anxiety (e.g., time spent in the center of the open field and ventures into the open-arms of the elevated plus maze) were not affected by BrSp in males or females. Notably, the outcomes of these tests probe state-like anxiety, in which situations create anxiety [ 40 ], rather than trait anxiety, which reflect fears that are not apparent to others [ 41 ] Therefore, it is possible that the beneficial effects of BrSp on trait-anxiety may be more pronounced, and thus future studies investigating whether this treatment may be useful in mitigating anxiety-like behaviors in other contexts requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Broccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats

Noble

Jahandideh

Armstrong

et al. 2022

IJERPH

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Antioxidants and anti-inflammatory compounds are potential candidates to prevent age-related chronic diseases. Broccoli sprouts (BrSp) are a rich source of sulforaphane—a bioactive metabolite known for its antioxidant and anti-inflammatory properties. We tested the effect of chronic BrSp feeding on age-related decline in cardiometabolic health and lifespan in rats. Male and female Long-Evans rats were fed a control diet with or without dried BrSp (300 mg/kg body weight, 3 times per week) from 4 months of age until death. Body weight, body composition, blood pressure, heart function, and glucose and insulin tolerance were measured at 10, 16, 20, and 22 months of age. Behavioral traits were also examined at 18 months of age. BrSp feeding prolonged life span in females, whereas in males the positive effects on longevity were more pronounced in a subgroup of males (last 25% of survivors). Despite having modest effects on behavior, BrSp profoundly affected cardiometabolic parameters in a sex-dependent manner. BrSp-fed females had a lower body weight and visceral adiposity while BrSp-fed males exhibited improved glucose tolerance and reduced blood pressure when compared to their control counterparts. These findings highlight the sex-dependent benefits of BrSp on improving longevity and delaying cardiometabolic decline associated with aging in rats.

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The effect of exercise on anxiety- and depression-like behavior of aged rats

Cited by 16 publications

References 57 publications

Impact of Melatonin Deficit on Emotional Status and Oxidative Stress-Induced Changes in Sphingomyelin and Cholesterol Level in Young Adult, Mature, and Aged Rats

Impact of Melatonin Deficit on Emotional Status and Oxidative Stress-Induced Changes in Sphingomyelin and Cholesterol Level in Young Adult, Mature, and Aged Rats

Beneficial Effects of Exercise on Depression and Anxiety During the Covid-19 Pandemic: A Narrative Review

Broccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats

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