The effect of exercise on suicidal ideation and behaviors: A systematic review and meta-analysis of randomized controlled trials

Fabiano, Nicholas; Gupta, Arnav; Fiedorowicz, Jess G.; Firth, Joseph; Stubbs, Brendon; Vancampfort, Davy; Schuch, Felipe Barreto; Carr, Lucas J.; Solmi, Marco

doi:10.1016/j.jad.2023.02.071

Cited by 14 publications

(13 citation statements)

References 110 publications

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“…In fact, according to the GEE models, the experimental intervention reduced patients’ anxiety and depressive symptoms and improved their quality of life (QoL). The improvement of patients’ QoL is crucial to strengthen their motivation toward healthy lifestyle behaviours and thus it should always be the target of behavioural interventions focusing on patients’ physical health [ 58 ]. This result is in line with those reported by Sampasa-Kanyinga et al [ 59 ] and Kleppang et al [ 60 ], which reported that the improvement of healthy lifestyle is associated with reduced anxiety and depressive symptoms as well as suicide ideation and attempts.…”

Section: Discussionmentioning

confidence: 99%

One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial

Luciano,

Sampogna,

D’Ambrosio

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains. Patients were randomly allocated to receive the six-month experimental intervention (LIFESTYLE) or a behavioural control intervention. All enrolled patients were assessed at baseline and after one year. We recruited 401 patients (206 in the experimental and 195 in the control group) with a diagnosis of schizophrenia or other psychotic disorder (29.9%), bipolar disorder (43.3%), or major depression (26.9%). At one year, patients receiving the experimental intervention reported an improvement in body mass index, body weight, waist circumference, HOMA-IR index, anxiety and depressive symptoms and in quality of life. Our findings confirm the efficacy of the LIFESTYLE intervention in improving physical and mental health-related outcomes in patients with severe mental illnesses after one year.

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Section: Discussionmentioning

confidence: 99%

One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial

Luciano,

Sampogna,

D’Ambrosio

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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“… 1 Another 2023 meta-analysis of RCTs found that exercise decreased suicide attempts among people with mental or physical illness. 2 …”

Section: Exercise Effectively Treats Depression and May Decrease Suic...mentioning

confidence: 99%

“… 3 While meta-analyses have found positive effects of exercise interventions, these largely involved willing participants with professional support. 1 , 2 Addressing psychological barriers is important for exercise implementation.…”

Section: Psychological Barriers To Exercise Should Be Addressedmentioning

confidence: 99%

“…Exercise in this population is well tolerated, with minor adverse events such as joint pain, headache, and fatigue. 1 , 2 Patients should be screened for pre-existing comorbidities such as injuries, physical inability, and conditions such as severe cardiovascular disease that increase the risk of exercise. 1 Among those without such comorbidities, clinical supervision is not necessary for safety.…”

Section: Exercise Interventions Are Generally Safementioning

confidence: 99%

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Exercise as a treatment for depression

Zhou,

Fabiano

2024

CMAJ

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“…Currently, the literature regarding the effects of exercise on suicide is inconclusive, with two recent systematic reviews indicating that exercise may decrease suicide attempts. No clear association was delineated between suicidal ideation or death by suicide, however 56…”

mentioning

confidence: 97%

The effect of exercise on suicide in people with depression

Fabiano

2024

BMJ

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The effect of exercise on suicidal ideation and behaviors: A systematic review and meta-analysis of randomized controlled trials

Cited by 14 publications

References 110 publications

One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial

One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial

Exercise as a treatment for depression

The effect of exercise on suicide in people with depression

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