The effect of exercise on high-level mobility in individuals with neurodegenerative disease: a systematic literature review

Smith, Moira; Barker, Ruth; Williams, Gavin; Carr, Jennifer J.; Gunnarsson, Ronny

doi:10.1016/j.physio.2019.04.003

Cited by 13 publications

(20 citation statements)

References 63 publications

(171 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…That choice may include exercise that demands a high‐level of mobility such as running, trail walking or squash (Smith et al., 2019). To date, clinical trials have not commonly targeted interventions which support individuals with MS to engage in exercise that demands a high‐level of mobility (Smith, Barker, et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Consumer experience of a flexible exercise participation program (FEPP) for individuals with multiple sclerosis: A mixed‐methods study

Smith

Neibling

Williams

et al. 2021

Physiotherapy Res Intl

Self Cite

View full text Add to dashboard Cite

Background and Purpose:The flexible exercise participation program (FEPP) is a novel intervention developed to enable individuals with multiple sclerosis (MS) participate and progress in an exercise or sport of their choice. The FEPP is underpinned by guidelines on aerobic exercise for individuals with MS and is supported by a physiotherapist using behaviour change techniques. As part of a FEPP feasibility trial, the aim of this nested study was to explore the experience of participation in the FEPP from the perspective of individuals with MS. The objectives were to (i) determine the acceptability of the FEPP and (ii) identify recommendations for improvement.Methods: A mixed methods study using a sequential explanatory design was conducted. Part I consisted of a quantitative participant survey. Survey data were analysed descriptively using SPSS and informed the protocol for part II -qualitative interviews. Interview data were analysed thematically using NVivo. Part III consisted of integration of quantitative and qualitative data to allow greater explanation of survey responses. Individuals with MS who had participated in the FEPP feasibility trial were invited to take part in the study. Results:The FEPP was highly acceptability to the 10 participants. Five themes emerged to describe the experience of participating in the FEPP: (i) exploring exercise boundaries, (ii) measuring energy, (iii) acknowledging accountability, (iv) adjusting to exercising in a pandemic and (v) sustaining participation. Recommendations for improving the FEPP included changes to energy level monitoring and incorporation of peer support mechanisms. Discussion: Participants found the FEPP highly acceptable and valued the flexibility to choose their own activity and the health professional support. Based on participant recommendations, future versions of the FEPP will include daily rather than weekly monitoring of exercise and peer support to further enable individuals with MS to find the right balance with exercise and sport.

show abstract

Section: Introductionmentioning

confidence: 99%

Consumer experience of a flexible exercise participation program (FEPP) for individuals with multiple sclerosis: A mixed‐methods study

Smith

Neibling

Williams

et al. 2021

Physiotherapy Res Intl

Self Cite

View full text Add to dashboard Cite

show abstract

“…Commonly, exercise interventions for individuals with MS are provided in a clinical or home-based setting where the individual follows a prescribed activity or exercise programme. High-level mobility activities such as running, sport or outdoor leisure pursuits are not typically targeted 2. Instead, exercise interventions prescribed include progressive resistance training, balance training and stationary cycling, addressing impairments such as strength and balance 3–5.…”

Section: Introductionmentioning

confidence: 99%

“…Instead, exercise interventions prescribed include progressive resistance training, balance training and stationary cycling, addressing impairments such as strength and balance 3–5. Functional outcomes are typically focused on walking6 7 with no attention to the benefits for high-level mobility, even for those who are higher functioning 2. Benefits of participation in regular sport and exercise according to the preference of individuals with MS have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Finding the right balance with participation in exercise and sport for individuals with multiple sclerosis: protocol for a pre and post intervention feasibility study

2020

Self Cite

View full text Add to dashboard Cite

IntroductionIndividuals with minimal disability from multiple sclerosis (MS) requested advice on finding the right balance, between too much and too little exercise, when participating in their choice of sport or exercise. To optimise exercise participation during the early stages of the disease, a flexible exercise participation programme (FEPP) has been developed. The FEPP is novel because it provides guidance and support for individuals with MS to participate and progress in theirpreferredsport or exercise. The primary objective was to assess the feasibility of the FEPP. The secondary objective was to assess the feasibility of a larger trial to demonstrate the efficacy of the FEPP.Methods and analysisA stage I feasibility study of the FEPP, using a single group preintervention/post-intervention design, will be conducted with 16 participants with minimal disability from MS (Expanded Disability Status Scale level of 0–3.5). The 12-week FEPP will guide participants to independently participate in their preferred sport or exercise at a location of their choice. Exercise progression will be guided by individual energy levels and a weekly telephone coaching session with a physiotherapist. Participation in exercise or sport will be recorded in parallel with assessment of disease biomarkers (plasma cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-γ and tumour necrosis factor (TNF)), subjective vitality and high-level mobility. Acceptability of the FEPP will be assessed using a sequential explanatory mixed methods design where the findings of a participant survey will inform the interview guide for a series of focus groups.Feasibility of a larger trial will be assessed via process, resources, management and scientific metrics. Progression to a larger trial will depend on the achievement of specified minimum success criteria.Ethics and disseminationEthical approval has been obtained for this study from the James Cook University Human Research Ethics Committee (H7956). Dissemination of findings is planned via peer-reviewed journals, conference presentations and media releases. The protocol date was 21 December 2019, V.1.Trial registration numberThe trial is registered with Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12620000076976.

show abstract

“…These interventions widely comprise "Any bodily movement produced by skeletal muscles that requires energy expenditure" and any type of structured exercise (15) including gait and balance training, video-gaming (16)(17)(18) and cognitive behaviour interventions (19)(20)(21). However, although physical activities are promoted as an essential part of the clinical management across RNCs, evidence supporting physical activity interventions is still lacking in these conditions (22)(23)(24)(25)(26)(27). To date, there are significant gaps in understanding about which types of activities maintain physical functioning and increase participation in activities and quality of life across RNCs.…”

Section: Introductionmentioning

confidence: 99%

“…A second systematic review investigated the effect of exercise on high-level mobility (e.g. running or jumping) in individuals with neurodegenerative disease, such as multiple sclerosis, Parkinson's disease, HD and degenerative cerebellar disease(24). However, no new studies involving participants living with rare conditions were identified in the review, as the two intervention studies included(17,75) were reviewed in two previous systematic reviews included in the present scoping review(16,53).Outcome measuresSimilar to the interventions described in the present review, outcome measures were highly variable across the included systematic reviews and mostly assessed changes at the levels of body function (e.g.…”

mentioning

confidence: 99%

Physical activity and exercise interventions for people with rare neurological disorders: a scoping review of systematic reviews

Buscemi

Boaz²,

Dawes

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: People living with rare neurological conditions (RNCs) often face common physical, cognitive and psychological challenges that lead to reduced physical activity and associated deconditioning. Physical activity interventions are routinely utilised to address disease specific limitations with the intention of promoting participation in people with RNCs. This scoping review aimed to synthesise the body of evidence for such interventions as they are applied across a wide range of RNCs. Methods: We undertook a scoping review of systematic reviews of any type of physical activity and exercise interventions for adults with neuromuscular diseases, motor neurone disease, Huntington’s disease, progressive supranuclear palsy, multiple system atrophy, inherited ataxias and hereditary spastic paraplegia. The reviews were included if they reported at least one outcome that aimed to increase physical activity level at either the body structure/function, activity and/or participation levels. Results: Sixty-two articles were full-text screened of which 27 were included. Most studies involved interventions in people with neuromuscular diseases. No reviews of interventions in hereditary spastic paraparesis were identified. The majority of reviews included studies of structured exercise using outcome measures at the level of body function and functional activity. Interventions were grouped as: i) combined interventions; ii) muscle strength training; iii) respiratory training; iv) aerobic training. Frequency, intensity, time and type of structured exercise utilised varied considerably across studies. Most studies were methodologically limited by small sample sizes, variation in exercise dose and training duration.Conclusions: To date, primary attention has been given to structured exercise interventions, which have demonstrated to have a low to uncertain level of evidence. Novel approaches to implementing common interventions and modalities are needed to increase accessibility and engagement in physical activity irrespective of disease type. Further exploration is warranted to achieve consensus on outcome measures that reflect areas of importance and relevance to people with RNCs.

show abstract

The effect of exercise on high-level mobility in individuals with neurodegenerative disease: a systematic literature review

Abstract: Ronny (2020) The effect of exercise on high-level mobility in individuals with neurodegenerative disease: a systematic literature review. Physiotherapy, 106 pp.

Cited by 13 publications

References 63 publications

Consumer experience of a flexible exercise participation program (FEPP) for individuals with multiple sclerosis: A mixed‐methods study

Consumer experience of a flexible exercise participation program (FEPP) for individuals with multiple sclerosis: A mixed‐methods study

Finding the right balance with participation in exercise and sport for individuals with multiple sclerosis: protocol for a pre and post intervention feasibility study

Physical activity and exercise interventions for people with rare neurological disorders: a scoping review of systematic reviews

Contact Info

Product

Resources

About