1908
DOI: 10.1113/jphysiol.1908.sp001258
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The effect of excess of carbon dioxide and of want of oxygen upon the respiration and the circulation

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Cited by 113 publications
(46 citation statements)
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(4 reference statements)
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“…As a group, HLT subjects would appear to behave no differently from matched control subjects in ability to hold their breath or in the time course of improvement in air hunger following the end of breath-holding; however, two of the four HLT subjects reported full relief only after a delay longer than that reported by all five control subjects. It is known that resumption of breathing at the end of breath-holding is accompanied by rapid relief of discomfort even when any improvement in blood gas status is prevented (Hill & Flack, 1908;Fowler, 1954); this has led to the view that afferent feedback from mechanoreceptors within the respiratory system provides the neural basis for such relief. All HLT subjects studied reported some relief of respiratory discomfort within 2 s of breath-hold break point (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…As a group, HLT subjects would appear to behave no differently from matched control subjects in ability to hold their breath or in the time course of improvement in air hunger following the end of breath-holding; however, two of the four HLT subjects reported full relief only after a delay longer than that reported by all five control subjects. It is known that resumption of breathing at the end of breath-holding is accompanied by rapid relief of discomfort even when any improvement in blood gas status is prevented (Hill & Flack, 1908;Fowler, 1954); this has led to the view that afferent feedback from mechanoreceptors within the respiratory system provides the neural basis for such relief. All HLT subjects studied reported some relief of respiratory discomfort within 2 s of breath-hold break point (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…Mechanoreceptors in the lungs, airways, and chest wall provide afferent information about achieved pulmonary ventilation and can inhibit (relieve) air hunger/unsatisfied inspiration (98)(99)(100)(101)(102)(103). In animal models of emphysema, pulmonary stretch receptor discharge is decreased (104).…”
Section: Qualities Of Dyspneamentioning
confidence: 99%
“…The use of voluntary breath hold as a probe to gain insight into the physiological mechanisms of shortness of breath dates to at least a century ago (Hill and Flack 1908;Flume et al 1994;Nishino et al 1996). Breath holds are normally terminated due to a perception of the need for air ('air hunger') that becomes intolerable; hence, breath hold time (taken conventionally as the time during which there is no airflow at the airway opening) has been used as a measure of air hunger tolerance (Lin et al 1974).…”
Section: Introductionmentioning
confidence: 99%