Abstract:BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) have unclear impacts on emphysema measurement using computed tomography (CT)-derived 15th percentile lung density (PD15). The aim of this study was to assess the influence of AECOPD on PD15 lung density in alpha-1 antitrypsin deficiency.MethodsIn apost hocanalysisof the RAPID trial, raw marginal residuals of PD15 (measured - predicted) were determined by fitting a regression line to individual patient CT data. These deviations from… Show more
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