The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis

Majdinasab, Nastaran; Namjoyan, Foroogh; Taghizadeh, Mohsen; Saki, Hamid

doi:10.2147/ndt.s149403

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…The oil of primrose has been used for the treatment of MS disease due to its immune-modulating and anti-inflammatory effects. Based on the concentration of primrose, it can show different inhibitory effects against various bacteria (Gram-positive and Gram-negative) [ 266 , 267 , 268 ]. The EO of primrose contains gamma linolenic acid (GLA).…”

Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

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Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal materials are found in medicines. Herbs can be used in the form of plant extracts or as their active components. Furthermore, most of the world’s populations used herbal materials due to their strong antimicrobial properties and primary healthcare benefits. For example, herbs are an excellent material to replace nanosilver as an antibiotic and antiviral agent. The use of nanosilver involves an ROS-mediated mechanism that might lead to oxidative stress-related cancer, cytotoxicity, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Therefore, existing antibiotic drugs can be replaced with biomaterials such as herbal medicine with high antimicrobial, antiviral, and antioxidant activity. This review paper highlights the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials. Antimicrobial activity, radical scavenger ability, the potential for antimicrobial, antiviral, and anticancer agents, and efficacy in eliminating bacteria and viruses and scavenging free radicals in herbal materials are discussed in this review. The presented herbal antimicrobial agents in this review include clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic, which are all summarized.

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Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

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“…Saki, in a study that investigated the effect of evening primrose oil on depression, stated that although the mean score of depression and the patients' performance had been significantly reduced at the beginning of the study, weeks 4, 8, and 12 in both groups (evening primrose oil or nortriptyline therapy), in patients who received evening primrose oil, the decrease was more significant [ 35 ]. In a study, which has been conducted on patients with multiple sclerosis, it has been shown that using 1 g of evening primrose oil every 12 h for 3 months can significantly decrease pain and fatigue and also increase their life satisfaction, cognitive function and vitality [ 36 ]. SafaaHussain et al evaluated the effect of evening primrose oil in type 2 diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of evening primrose oil on postoperative pain after appendectomy: A double-blind, randomized, clinical trial

et al. 2020

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Background and objective: Despite advances in surgical techniques and pharmacology, postoperative pain remains a common problem after appendectomy, and its management continues to be suboptimal. The aim of this study was to evaluate the effect of evening primrose oil on the reduction of postoperative pain after appendectomy.Materials and methods: In a double-blind, randomized, clinical trial, a total of 80 adults patients with acute appendicitis who were undergoing appendectomy at the Shahid Beheshti Emdad Hospital in Sabzevar, were included. Patients were randomly allocated into two equally sized groups (n ¼ 40). In postoperative period and after recovering from the anesthesia, each of the intervention and control groups received one evening primrose (1000 mg) or placebo capsules every 30 min for 3 times, respectively. All patients in both groups were asked to rate the intensity of their pain on a 0e10 point Visual Analogue Scale (VAS) and also McGill pain questionnaire, before and 1 h after the last administration of the drug, postoperatively.Results: In patients who received evening primrose, both VAS and McGill pain intensity scores significantly decreased after intervention, when compared prior to initiation of the intervention (p < 0.0001). While in the control group, changes of pain intensity scores were not significantly different before and after the intervention (p > 0.05).Conclusion: It seems that oral evening primrose can be used as a simple and safe potential adjunctive treatment for postoperative pain control after appendectomy.

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“…The seeds of Oenothera biennis are employed in the production of evening Primerose oil. This oil has shown considerable antidepressant property in a rodent model of Chronic Fatigue Syndrome 99 .…”

Section: Oenothera Biennismentioning

confidence: 99%

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2020

IJPSR

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Depression is a common heterogeneous, debilitating and lifethreatening mood disorder affecting different segments of the community. Several chemical and synthetic medicines as standard are being employed to treat depression and may lead to complete recovery in only 50% of clinically depressed patients but causes many adverse effects. Thus, scientists are increasing their interest in research towards the utility of medicinal plants for antidepressant activity. Several medicinal plants and its derived medicinal products have been reported to exert antidepressant action in different animal models by the combined effect of their phytoconstituents. In the brain, the alteration in level of various endogenous molecules likes noradrenaline (NA), acetylcholine (Ach), serotonin (5-HT), dopamine, glucocorticoid, γaminobutyric acid (GABA), corticotrophin-releasing hormone (CRH) and hippocampal volume are responsible for depression. Therefore, most medicinal plants through synaptic regulation of serotonin, noradrenaline, and dopamine, overcome the altered level of monoamines in the brain and also reinforcing antioxidant defense mechanism, regulate hypothalamic-pituitaryadrenal axis activity and reducing inflammatory mediators. So, herbal medicines are widely used in contrast to allopathic or synthetic medicines globally because of their least side effects and wide therapeutic applications. The present review aims to highlight the medicinal plants and their antidepressant mechanism involved in the treatment of depression by animal model studies. INTRODUCTION:In the present world, there is several life-threatening neurological disorders such as Alzheimer's, epilepsy, multiple sclerosis, Parkinson's disease, brain tumor, etc. Besides them, there are certain disorders such as mood swing, anxiety, and depression, which may not be life-threatening, but at the same time, degrade the quality of life.

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The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis

Cited by 25 publications

References 23 publications

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Effect of evening primrose oil on postoperative pain after appendectomy: A double-blind, randomized, clinical trial

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