The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs

Miyamoto, Hizuru; Onuma, Hiroomi; Shigematsu, Hisao; Suzuki, Seiji; Sakashita, Hideaki

doi:10.1016/j.jcms.2007.06.001

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2012

2024

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Cited by 7 publications

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“…Orthotopic large animal models need to be performed to examine the safety and efficacy of tissueengineered constructs prior to translation. Toward selection, possible species for performing regenerative studies include sheep [77], goats [78], dogs [79], farm pigs [80], and minipigs [81]. The farm pig and minipig are two suitable models that have been recently used for regenerative studies due to their similarities to humans in chewing patterns, diet, and anatomy [3,[81][82][83][84][85].…”

Section: Novel and Cogent Translational Studiesmentioning

confidence: 99%

Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc

Donahue

Athanasiou

2019

Trends in Molecular Medicine

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Current treatments for TMDs lack long-term efficacy and are palliative, motivating tissue-engineering for repair or replacement of the injured or ailing tissues in the TMJ, such as the disc. Scaffold-based or scaffold-free approaches, cell sources, biochemical stimuli, and mechanical stimuli are all elements of the tissue-engineering process that need to be considered to tailor TMJ disc construct properties. Large animals can serve as models of human TMDs orthotopic implantation in large animal models is a necessary translational step.

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