“…Studies of nonproliferative retinopathy suggested that a 6-month course of EHDP administration may improve retinopathy. 25 EHDP in large doses may also suppress bone turnover, inhibits bone mineralization and affect tooth development, deleterious effects that discourage general use. 38,39 The therapeutic use of fructose-1, 6 diphosphate (FDP) in diabetes is much more attractive since it is a natural intermediate in glycolysis and also acts as human bioenergy, delivering intracellular phosphorus and 4 moles ATP per mole of FDP.…”