The effect of ethylenediamine-tetraacetic acid on Candida albicans

Şen, Bilge Hakan; Akdeniz, B. Güniz; Denizci, Aziz Akın

doi:10.1067/moe.2000.109640

Cited by 63 publications

(51 citation statements)

References 39 publications

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“…In a recent study, Sen et al (2000) demonstrated antifungal properties of several endodontic disinfectants and irrigating solutions. They found that EDTA showed the highest antifungal activity, while povidone-iodine had the weakest capacity.…”

Section: Susceptibility Of Candida Species To Disinfectantsmentioning

confidence: 99%

Yeasts in Apical Periodontitis

Waltimo

Şen

Meurman

et al. 2003

Critical Reviews in Oral Biology & Medicine

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Microbiological reports of apical periodontitis have revealed that yeasts can be isolated from approximately 5-20% of infected root canals. They occur either in pure cultures or together with bacteria. Almost all isolated yeasts belong to the genus Candida, and the predominant species is C. albicans. Pheno- and genotypic profiles of C. albicans isolates show heterogeneity comparable with those of isolates from other oral sites. C. albicans expresses several virulence factors that are capable of infecting the dentin-pulp complex, including dentinal tubules. This causes, consequentially, an inflammatory response around the root apex, which suggests a pathogenic role for this organism in apical periodontitis. Yeasts are particularly associated with persistent root canal infections that do not respond favorably to conservative root canal therapy. This may be due to the resistance of all oral Candida species against a commonly used topical medicament, calcium hydroxide. However, other antimicrobial agents may offer alternative therapeutic approaches and improve the treatment of these persistent cases of apical periodontitis.

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Section: Susceptibility Of Candida Species To Disinfectantsmentioning

confidence: 99%

Yeasts in Apical Periodontitis

Waltimo

Şen

Meurman

et al. 2003

Critical Reviews in Oral Biology & Medicine

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“…For anatomical reasons, part of the root canal space often remains untouched by instrumentation, regardless of the endodontic technique employed [7,8]. Lateral isthmuses and dentinal tubules cannot be reached by standard techniques of disinfection [9,10], and the permeability of irrigants in infected dentinal tubules is limited and chelating agents (e.g., 17% EDTA solution) do not seem to be effective on yeast-like microorganisms [11]. In this regard, sodium hypochlorite (NaOCl) penetrates to a depth of approximately 130 mm in dentinal tubules [12], while tubular infection may occur closer to the cementumdentine junction (up to 1,000 mm) [13].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of Enterococcus faecalis in dental root canals in vitro

Foschi¹,

Fontana²,

Ruggiero³

et al. 2007

Lasers Surg Med

143

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“…That low numbers of cells survive endodontic treatment implies an ability of some species to withstand instrumentation and antimicrobial irrigation, however numerous reports confirm the bactericidal efficacy of sodium hypochlorite against species involved in persistent infection such as A. israelii, 65 E. faecalis [66][67][68] and Candida. [69][70][71] Thus, these species may have the capacity to shelter from the main root canal in web-like areas, canal ramifications or dentinal tubules where some level of protection or buffering of the antimicrobial agent is possible. 72,73 Although most root canal bacteria are sensitive to the high pH of calcium hydroxide, 74 several species involved in persistent infection are known to have a capacity to resist a high pH.…”

Section: Properties Of Species Associated With Persistent Endodontic mentioning

confidence: 99%

A big role for the very small—understanding the endodontic microbial flora

Figdor

Sundqvist

2007

Australian Dental Journal

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Apical periodontitis, an inflammatory process around the apex of a tooth root, is primarily a sequel to microbial infection of the pulp space. The microbial flora is composed of a restricted group of the total oral flora, selected by environmental pressures of anaerobiosis, nutrition and competition with other species and inhabits the root canal as a biofilm of coaggregated communities in an extracellular matrix. The untreated infected canal is generally composed of a polymicrobial mix with approximately equal proportions of Gram-positive and Gram-negative species, dominated by obligate anaerobes. The type of microbial flora in the root-filled tooth with persistent apical periodontitis has very different characteristics. These infections are characterized by one or just a few species, predominantly Grampositive micro-organisms with an equal distribution of facultative and obligate anaerobes. Enterococcus faecalis has been a conspicuous finding in most studies. Because the primary aetiological problem is infection, endodontic treatment is directed at control and elimination of the root canal flora by working in a sterile way. Based on current knowledge, the best available method for obtaining clean, microbe-free root canals is by instrumentation with antimicrobial irrigation reinforced by an intracanal dressing with calcium hydroxide.Key words: Root canal flora, ecological niche, antibacterial treatment, root canal preparation, root canal irrigants.Abbreviations and acronyms: EDTA = ethylenediamine tetra-acetic acid; FTM = fluid thioglycolate medium; NaOCI = sodium hypochlorite solution; SEM = scanning electron microscope.

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The effect of ethylenediamine-tetraacetic acid on Candida albicans

Cited by 63 publications

References 39 publications

Yeasts in Apical Periodontitis

Yeasts in Apical Periodontitis

Photodynamic inactivation of Enterococcus faecalis in dental root canals in vitro

A big role for the very small—understanding the endodontic microbial flora

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