The Effect of Ether Anaesthesia on the Electrical Activity of Nerve

Forbes, Alexander; McIntosh, R.; Sefton, William

doi:10.1152/ajplegacy.1916.40.4.503

Cited by 7 publications

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“…Effects of inhalation anaesthetics on conduction in the aortic nerve. In agreement with previous findings on other nerves (Forbes, McIntosh & Sefton, 1916;Larrabee & Posternak, 1952;Austin & Pask, 1952), the inhalation anaesthetics (in the clinical doses used) did not affect the conduction velocity or stimulation threshold of fibres in the aortic nerve. Figure 4 shows a sequence of compound action potentials, recorded at voltages maximal for A aortic fibres.…”

Section: Resuiltssupporting

confidence: 92%

The effects of cyclopropane, halothane and ether on central baroreceptor pathways

Biscoe¹,

Millar²

1966

The Journal of Physiology

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SUMMARY1. The reductions in arterial pressure and preganglionic sympathetic activity evoked by aortic nerve stimulation in the rabbit were studied before and during administration of constant inspired concentrations of the inhalation anaesthetics cyclopropane, halothane, and ether. The background anaesthetic was pentobarbitone, gallamine triethiodide was given, and pulmonary ventilation was with 100 % oxygen.2. During light pentobarbitone anaesthesia, aortic nerve stimulation usually induced similar reductions in arterial pressure and preganglionic discharge, expressed as the maximum percentage reduction from prestimulation levels. There were two components in the sympathetic responses, attributable to A and C fibre excitation in the aortic nerve, which was also shown to contain a third fibre group with properties similar to those of B fibres.3. The arterial pressure, heart rate, and preganglionic sympathetic responses to aortic nerve stimulation were rapidly and profoundly inhibited by 50 % cyclopropane, which also produced arterial hypertension. 6. It is concluded that the three anaesthetics significantly inhibit

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