The Effect of Ethanol on the Metabolism of Prostaglandins and Related Compounds

Pennington, Sam N.; Smith, Carlton; Strider, John B.

doi:10.1007/978-1-4757-1419-7_54

Cited by 3 publications

(2 citation statements)

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“…There is evidence that this diuresis is due to inhibition of antidiuretic hormone release [2], There is also evidence that the diuretic effect of ethanol may occur without reduction of vasopressin levels [3], Since ethanol may affect arachidonic acid metabolism and subsequent prostaglandin synthesis [4], studies were undertaken to determine whether diuresis due to ethanol is mediated by enhanced renal synthesis of prostaglandin E2 (PGE2) a potent vasopressin antagonist. 6 rabbits, weighing between 2.5 and 3.2 kg, were studied in standard metabolic cages.…”

Section: Introductionmentioning

confidence: 99%

Ethanol-Induced Water Diuresis Is Not Prostaglandin Dependent

Zawada¹,

Johnson²,

Sica³

1985

Nephron

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Previous studies have demonstrated an effect of alcohol on arachidonic acid metabolism. These studies were undertaken to determine if the water diuresis of alcohol is due to enhanced prostaglandin E₂ (PGE₂) production, a known antidiuretic hormone antagonist. 6 rabbits, weighing between 2.5 and 3.2 kg, were studied in standard metabolic cages during 4 periods: control, indomethacin administration, ethanol administration, and ethanol and indomethacin. 10 ml of 100% alcohol was added to their water in periods 3 and 4, and 5 mg/kg indomethacin was given during periods 2 and 4. We recorded urine output, urine osmolality, sodium excretion, potassium excretion, and PGE₂excretion. Urine flow rate significantly increased in periods 3 and 4 from 79 ± 7 to 177 ± 13 and 165 ± 11 cm³/day, respectively, p < 0.001 for both, compared to control. Indomethacin, therefore, did not prevent the water diuresis. Urinary PGE₂ excretion was low (125 ± 13 ng/day) with ethanol administration compared to control (897 ± 71 ng/day, p < 0.001). Levels were similar to those seen with the inhibitor indomethacin (105 ± 22 ng/day, n.s.). These low levels with ethanol were observed at the same time of the significant free water diuresis. We conclude that the water diuresis produced by acute ethanol administration is not mediated by enhanced renal PGE₂ production.

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Section: Introductionmentioning

confidence: 99%

Ethanol-Induced Water Diuresis Is Not Prostaglandin Dependent

Zawada¹,

Johnson²,

Sica³

1985

Nephron

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“…Linkola et al [3] reported that the diuretic effect of ethanol may occur without reduction of vasopressin levels. Since ethanol may affect prostaglandin synthesis [4] , studies were undertaken to determine whether diure sis due to ethanol was mediated by enhanced renal syn thesis of prostaglandin E2 (PGE2), a potent vasopressin antagonist.We were very interested in the article by Zawada et al [5] . These authors investigated urine output, urine osmo lality, sodium, potassium and PGE2 excretion in rabbits during four periods: ( 1 ) control, (2) indomethacin admin istration, (3) ethanol administration and (4) ethanol and indomethacin administration.…”

mentioning

confidence: 99%

Ethanol-Induced Water Diuresis: One of a Spectrum of Renal Defects Resulting from Ethanol Toxicity

Marchi¹,

Cecchin²

1986

Nephron

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Effect of acute and chronic alcohol feeding on prostaglandin E2 biosynthesis in rat stomach

et al. 1988

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The effect of acute and chronic alcohol ingestion on gastric prostaglandin E2 synthesis and the PGE2 content in the stomach was studied in rats. Up to 8 hr following a single oral load of 20% alcohol (v/v; 4 g/kg body weight), the PGE2 synthesis in isolated microsomes from rat stomach remained unchanged as compared with control values. Feeding a liquid alcohol-containing diet (37% of total Joules) for 1, 6, or 12 weeks significantly decreased the rate of PGE2 synthesis (percentage inhibition as compared with control values 39, 27, and 57, respectively). In addition, chronic alcohol feeding led to a drop in the tissue content of PGE2, the decrease being more pronounced after 6 (-49%) and 12 (-58%) weeks than after 1 week (-24%). The results suggest that the inhibition of endogenous PGE2 synthesis in the stomach following ingestion of appreciable quantities of alcohol might play a role in the pathogenesis of alcohol-induced injury of the gastric mucosa.

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The Effect of Ethanol on the Metabolism of Prostaglandins and Related Compounds

Cited by 3 publications

References 1 publication

Ethanol-Induced Water Diuresis Is Not Prostaglandin Dependent

Ethanol-Induced Water Diuresis Is Not Prostaglandin Dependent

Ethanol-Induced Water Diuresis: One of a Spectrum of Renal Defects Resulting from Ethanol Toxicity

Effect of acute and chronic alcohol feeding on prostaglandin E2 biosynthesis in rat stomach

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