The effect of ethanol metabolism on levels of oxidized and reduced nicotinamide-adenine dinucleotide in liver, kidney, and heart

The Effect of Prolonged Administration of Ethanol on Cardiac Metabolism and Performance in the Dog

“…Since most investigators failed to demonstrate alcohol dehydrogenase activity in the heart, it is unlikely that heart muscle itself can metabolize ethanol (8,21). Although some activity of this enzyme has been found in coronary sinus blood of chronic alcoholics (22), the overwhelming evidence now speaks against the presence of this enzyme in the heart (8,21).…”

Measurements of urinary pantothenic acid excretions of alcoholic patients.

“…Protein, vitamin and mineral deficiencies and disorders of fat and carbohy drate metabolism have been frequently observed in alcoholic patients. The increased caloric intake provided by ethanol may increase the requirement for nicotinic acid and riboflavin (9). The tendency for a deficiency of B-vitamins to be associated with increased alcohol consumption in animals has been reported by WILLIAMS (10).…”

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“…Ethanol oxidation in mammalian species causes a sharp increase in the NADH/NAD ratio as a result of the oxidation of ethanol via ADH (Smith and Newman, 1959;Cherrick and Leevy, 1965;McCaffrey et al, 1974;Williamson et al, 1974). Further the rate limiting step in ethanol oxidation is the reoxidation of NADH via the a-glycerophosphate and the malate-aspartate shuttle systems and the mitochondrial respiratory chain (Videla and Israel, 1970;Lindros et al, 1972;Lundquist et al, 1974;Williamson et al, 1974;Meijer et al, 1975;Cederbaum et al, 1977).…”