The effect of ethanol drinking on opioid analgesia and receptors in mice

Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone

“…Binding studies showed that chronic ethanol reduces the density of m opioid receptors in various brain areas (Rosin et al 1999;Turchan et al 1999;Chen and Lawrence 2000), and also reduces the analgesic effects of morphine without altering the pharmacokinetic of this opiate (Shah et al 1997). In light of this literature, it is possible that in rats with a recent history of dependence (i.e.…”

Effects of ethanol on deep pain evoked by formalin injected in TMJ of rat

“…In another group, the nociception assay was accomplished 10 days after ethanol or water consumption (control group) to evaluate the development of tolerance to antinociceptive effects of chronic ethanol. Blood ethanol concentrations remain elevated throughout chronic administration when this concentration of ethanol solution is used (Shah et al, 1997).…”

Environmental and intraperitoneal ethanol influences morphine antinociceptive effect in mice

“…The mechanism involved a modification in a G-protein mediated intracellular process. Similarly, Miranda et al (1983) observed that chronic administration of ethanol induced tolerance to morphine and Shah et al (1997) showed the lack of analgesic efficacy of opioid agonist after persistent oral ethanol administration. In contrast, Pohorecky and Pritesh (1987) demonstrated that an acute injection of ethanol (0.75-1.5 g/kg i.p.)…”

“…Exposure to ethanol seems to modify non-opioid endogenous analgesic routes (Bell et al, 1998). Several reports have suggested that ethanol may act as a potential modulator of endogenous opioid systems, probably modifying the opioid receptor density and gene expression (Pfeiffer et al, 1981;Shah et al, 1997;Turchan et al, 1999;Davis and Wu, 2001).…”