The Effect of Estrogen on Intracellular Ca2+ and Na+ Regulation in Heart Failure

Abstract

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Adjuvant Hormonotherapy and Cardiovascular Risk in Post-Menopausal Women with Breast Cancer: A Large Population-Based Cohort Study

“…The protective role of estrogen on the cardiovascular system in terms of favorable lipid profile and vasodilatation is well known [ 4 ]. However, as recent experimental evidence has emphasized, they exert a relevant cardioprotective role governing important intracellular processes, such as the intracellular ion flux [ 18 ] and the hypertrophic response of cardiomyocytes [ 19 ], as well as the collagen synthesis of the extracellular matrix in response to stressors [ 20 ]. It is currently assumed that the decline of estrogen at menopause is a major contributor to the pathogenesis of heart failure, particularly the phenotype with preserved ejection fraction, a clinical entity very common in older women with hypertension, central obesity and glycemic derangement [ 21 ].…”

Concentration of Zearalenone, Alpha-Zearalenol and Beta-Zearalenol in the Myocardium and the Results of Isometric Analyses of the Coronary Artery in Prepubertal Gilts

“…In contrast to the results reported by Yan et al [44], ZEN metabolites were not detected on D1 (or were below the sensitivity of the method), which could be due to the low supply of endogenous steroid hormones. According to other studies [48,49], a deficiency of ovarian hormones in mammals leads to pressure overload, thus compromising cardiac function. Supplementation with 17β-estradiol [50] or mycoestrogen can reverse these effects or alter the profile of estrogen hormones (by modulating feminization) [4,51].…”

The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea

“…Interestingly, estrogen has recently been implicated in Na current regulation and Ca store handling ( Firth et al, 2020 ). In a guinea pig HF model, Firth et al (2020) describe an exacerbation of pressure overload-induced HF in ovariectomized animals.…”

“…Interestingly, estrogen has recently been implicated in Na current regulation and Ca store handling ( Firth et al, 2020 ). In a guinea pig HF model, Firth et al (2020) describe an exacerbation of pressure overload-induced HF in ovariectomized animals. In addition to clinical endpoints, the authors report an increased sarcoplasmic reticulum (SR) Ca leak and reduced Ca transient amplitude as hallmarks of HF in vitro .…”

“…Several mechanisms of AF development have been associated with SDB, most notably increased reactive oxygen species (ROS) production, increased diastolic sarcoplasmic reticulum (SR) Ca leak, increased late I Na current ( Lebek et al, 2020b ), and reduced connexin 43 expression ( Hegner et al, 2021 ). Interestingly, estrogen has recently been implicated in Na current regulation and Ca store handling ( Firth et al, 2020 ).…”