2006
DOI: 10.1016/j.gie.2005.07.043
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The effect of erythromycin on video capsule endoscopy intestinal-transit time

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Cited by 77 publications
(46 citation statements)
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“…Wei et al [20] demonstrated the efficacy of mosapride. In contrast, Caddy et al [21] demonstrated that the motilin agonist erythromycin had no effect on GTT, SBTT, or the completion rate of CE examination, although Leung et al [24], in a retrospective trial, reported that erythromycin reduces GTT but not SBTT. Metoclopramide is a dopamine D 2 receptor antagonist, very efficient in treatment of stomach and small bowel motility disorders, including gastroparesis related to diabetes, prior vagotomy, and prior partial gastrectomy [25,26].…”
Section: Discussionmentioning
confidence: 95%
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“…Wei et al [20] demonstrated the efficacy of mosapride. In contrast, Caddy et al [21] demonstrated that the motilin agonist erythromycin had no effect on GTT, SBTT, or the completion rate of CE examination, although Leung et al [24], in a retrospective trial, reported that erythromycin reduces GTT but not SBTT. Metoclopramide is a dopamine D 2 receptor antagonist, very efficient in treatment of stomach and small bowel motility disorders, including gastroparesis related to diabetes, prior vagotomy, and prior partial gastrectomy [25,26].…”
Section: Discussionmentioning
confidence: 95%
“…In the study by Selby [15], the use of metoclopramide was associated not only with a higher rate of complete enteroscopy, but also with a lower gastric transit time (GTT) and a combined gastric and small bowel transit time (SBTT) [15]. Mosapride was also useful in CE [20], but erythromycin had no effect on GTT, SBTT, and cecal completion rate [21]. An ideal prokinetic for CE would substantially decrease GTT and increase the rate of total enteroscopy without affecting SBTT or reducing the diagnostic yield.…”
Section: Background and Aimsmentioning
confidence: 99%
“…ме-токлопрамид уменьшает время желудочного транзита капсулы и увеличивает вероятность успешного осмотра тонкой кишки [6]. напро-тив, использование эритромицина не оказыва-ет значимого эффекта на пропульсивную мо-торику тонкой кишки [1,7].…”
Section: материал и методыunclassified
“…в большинстве опубли-кованных исследований, относящихся к на-чальному периоду изучения капсульной эндо-скопии, приводятся данные о высокой, хотя и широко вариабельной, диагностической цен-ности этого метода при скрытом кровотечении (в пределах 38-93%, в среднем 75-80% в боль-шинстве исследований) [11]. однако надо учи-тывать, что в этих исследованиях были скон-центрированы селективно отобранные паци-енты с длительным анамнезом неясного Жкк, низкими показателями гемоглобина во время обследования, которым выполнялось огром-ное количество предшествующих эндоскопи-ческих осмотров с негативным результатом.…”
Section: результаты и обсуждениеunclassified
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