The effect of ergonovine on coronary vasodilatory reserve in patients with angiographically normal coronary arteries

Tatineni, Satyanarayana; Kern, Morton J.; Aguirre, Frank V.

doi:10.1016/0002-8703(92)90498-k

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…We showed that comparable vasoconstriction of proximal artery evoked with ergonovine did not affect the increase in CBF evoked with the contrast medium. Tatineni et al (36) demonstrated that diffuse narrowing of LAD with a 12±5% decrease in the diameter (comparable to the decrease in CSA by ACH in our patients with atherosclerotic lesions in LAD), that was caused by an intravenous administration of ergonovine (0.4 mg), did not attenuate the maximal hyperemic CBF response with papaverine (10 mg). Thus, we consider it unlikely that limited CBF response to ACH in patients with atherosclerotic lesions in proximal LAD resulted from mild vasoconstriction of proximal LAD induced by ACH.…”

Section: Discussionsupporting

confidence: 75%

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.

Egashira¹,

Inou²,

Hirooka³

et al. 1993

J. Clin. Invest.

343

131

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We examined whether coronary risk factors and atherosclerotic lesions in the study artery were associated with impaired endothelium-dependent dilation ofcoronary resistance arteries. Acetylcholine (ACH) at graded doses (1, 3, 10 and 30 ,g/min) and papaverine (10 mg) were selectively infused into the left anterior descending coronary artery of 28 patients, in whom the study artery was angiographically normal (n = 16) or with mild stenosis -40% (n = 12). Coronary blood flow (CBF) was estimated from the product of mean CBF velocity measured by an intracoronary Doppler catheter and the arterial cross-sectional area of the study artery determined by quantitative arteriography. ACH increased CBF in a dose-dependent manner. However, the maximum CBF response to ACH varied widely among patients (from 50% to 660%). By multivariate analysis, the presence of atherosclerotic lesions in the study artery was an independent predictor for impaired CBF response to ACH (P < 0.01). Hypertension (P < 0.001), hypercholesterolemia (r = -0.52, P < 0.005), age _ 50 yr (P < 0.01) and total number of coronary risk factors (r = -0.62, P < 0.001) were associated with the impaired increase in CBF with ACH by univariate analysis. The percent increase in CBF evoked with papaverine did not correlate with these risk factors. The results suggest that mild atherosclerotic lesions in the study artery and coronary risk factors are accompanied by impaired endothelium-dependent dilation of coronary resistance arteries evoked with ACH. Endothelial dysfunction of coronary resistance arteries may result in altered regulation of myocardial perfusion in patients with mild coronary atherosclerosis and coronary risk factors. (J. Clin. Invest. 1993. 91:29-37.)

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Section: Discussionsupporting

confidence: 75%

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.

Egashira¹,

Inou²,

Hirooka³

et al. 1993

J. Clin. Invest.

343

131

View full text Add to dashboard Cite

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“…29 We did not measure changes in arterial cross-sectional area of the large epicardial coronary vessels after papaverine (see "Methods"), which results in underestimation of the coronary blood flow response to papaverine. It is unlikely that this limitation is critical because vasodilation of the large epicardial vessels in response to papaverine does not correlate with aging (authors' unpublished observation).…”

Section: Endothelial Dysfunction In Resistance Coronary Arteriesmentioning

confidence: 99%

Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.

et al. 1993

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“…Methergine stimulates both alpha-adrenergic and serotonergic receptors and therefore exerts a direct constrictive effect on vascular smooth cells [4]. Acetylcholine infusion in the coronary artery causes the release of NO through activation of the muscarinic receptor on the surface of the endothelial cell with consequent relaxation of the smooth muscle cell and therefore vasodilation.…”

Section: Study Devicementioning

confidence: 99%

Morphological and functional evaluation of the bioresorption of the bioresorbable everolimus-eluting vascular scaffold using IVUS, echogenicity and vasomotion testing at two year follow-up: a patient level insight into the ABSORB A clinical trial

Sarno

Bruining

Onuma

et al. 2011

Int J Cardiovasc Imaging

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The aim of this study was to describe vaso-reactivity (by Acetylcholine and Methergine tests) at 2 year follow-up in parallel with the individual changes in the echogenicity characteristics of the polymer struts of the everolimus eluting bioresorbable vascular scaffold (BVS), from post-treatment to 2 year follow-up, in patients enrolled in the ABSORB Cohort A study. Intravascular ultrasound assessment was performed with a phased array catheter (EagleEye, Volcano Corporation, Cordova, CA, USA) with automated pullback at 0.5 mm per second. The % ratio at 6 months and 2 years [(Scaffold Area post PCI- Lumen Area)/Scaffold Area post PCI] was calculated as a measure of scaffold shrinkage. The % change of hyperechogenicity was defined as: ([post-procedural hyperechogenicity] - [2 year follow up hyperechogenicity])/[post-procedural hyperechogenicity]) × 100. The vasomotion test with intracoronary acetylcholine (10(-6) M) or intravenous methergine (0.4 mg) was performed at 2 years. Overall nine patients received all these analyses and were enrolled in the present analysis. A 50-96% reduction in hyperechogenicity was observed between baseline and 2 years, which corresponded to a change in vasoreactivity between 2 and 22%. A vasoconstriction of the scaffolded segment was observed in the 5 patients, who underwent the methergine test, with a mean decrease in lumen diameter after methergine of 9 ± 7% (P = 0.06), while vasodilatation occurred in the 4 patients who underwent the acetylcholine test with a mean increase in lumen diameter after acetylcholine of 8 ± 5% (P = 0.125). Bioresorption of the BVS is accompanied by re-establishment of both endothelial and non-endothelial dependent vasomotion.

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The effect of ergonovine on coronary vasodilatory reserve in patients with angiographically normal coronary arteries

Cited by 7 publications

References 13 publications

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.

Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.

Morphological and functional evaluation of the bioresorption of the bioresorbable everolimus-eluting vascular scaffold using IVUS, echogenicity and vasomotion testing at two year follow-up: a patient level insight into the ABSORB A clinical trial

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