The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps

Ljubičić, Neven; Banić, Marko; Kujundžić, Milan; Antić, Zoran; Vrkljan, Milan; Kovačević, Igor; Hrabar, Davor; Doko, Marko; Zovak, Mario; Mihatov, S

doi:10.1097/00042737-199907000-00008

Cited by 58 publications

(39 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association between hyperplastic polyps and H. pylori infection is still uncertain, with studies offering data for (20,21) and against it (12,22). There are many potential sources for bias in our study (retrospective study design, PPI at the time of endoscopy in 46.5% of patients, use of histology as the only method to address the presence of H. pylori without further knowledge of the location and number of the biopsies taken) to consider them an appropriate source to study this association.…”

Section: Discussionmentioning

confidence: 99%

Gastric polyps: analysis of endoscopic and histological features in our center

García‐Alonso

Martín-Mateos

González-Martín

et al. 2011

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Background and objective: the prevalence of gastric polyps in esophagogastroduodenoscopies (EGDs) ranges between 0.33 and 6.35%. The relative frequency of histological subspecies varies widely among published series. The objective is to describe the endoscopic and histological characteristics of the polypoid lesions, and to study possible associations.Material and methods: we retrospectively revised the EGDs done in our center in 2009. Demographic, endoscopic and histological data were gathered. We proceeded to a descriptive analysis and studied possible associations.Results: gastric polypoid lesions were found in 269 of the 6307 (4.2%) reviewed EGDs, 61% were found in women. Mean age was 64.93 years (SD: ±15.23). A single polyp was found in 186 patients (69.1%), over 10 lesions appeared in 31 (11.5%). An estimated size of ≤ 3 mm was found in 108 lesions (37.2%) and greater than 10 mm in 52 cases (17.9%). Most lesions were sessile (90.8%). The location of 34.8% was the gastric antrum, 39.3% were found in the gastric body and 25.9% were in the fundus. Chronic gastritis was confirmed in 53.5% of the patients and 46.5% had received PPIs. Histopathological diagnosis was: hyperplastic polyps 50.9%, fundic gland polyps 7.4%, adenomas 3%, adenocarcinomas 1.9% and normal mucosa 29.7%. We found no significant association between the histopathological type of lesions and the use of proton pump inhibitor.Conclusions: we found polypoid lesions in 4.2% of the EGDs. The most frequent histopathological findings were hyperplastic polyps (50.9%), followed by fundic gland polyps (7.4%), adenomas (3%), and adenocarcinomas (1.9%).

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric polyps: analysis of endoscopic and histological features in our center

García‐Alonso

Martín-Mateos

González-Martín

et al. 2011

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

show abstract

“…Tekintettel arra, hogy a H. pylori-eradikációval a HYPP-k regrediálhatnak, dysplasiával nem járó kis polipok esetén az eradikációt meg kell pró-bálni. Az esetek 80%-ában ez a kezelés sikeres [20,21].…”

Section: Megbeszélésunclassified

Prevalence of gastric polypoid lesions in a single endoscopic centre

et al. 2013

View full text Add to dashboard Cite

Bevezetés: A gyomor polypoid elváltozásainak hazai előfordulási gyakorisága nem ismert. Cél: A szerzők célul tűzték ki a Semmelweis Egyetem, II. Belgyógyászati Klinika endoszkópos centrumában a gyomorpolip gyakoriságának és az azt befolyásoló kóroki tényezőknek a vizsgálatát. Módszerek: 16 hónap alatt végzett felső panendoszkópiák egységes szövettani és klinikai adatait értékelték. Eredmények: 4174 gasztroszkópia során 193 (4,62%) polipot észlel-tek. A betegek átlagéletkora a diagnóziskor 65,9±12,7 év volt. A polipok 33,67%-a hyperplasticus, 31,09%-a fundusmirigypolip, 2,07%-a malignus volt. A fundusmirigypolipos betegek körében gyakoribb volt a protonpumpagátló-használat (p = 0,007), míg a hyperplasticus polipos csoportban gyakrabban találtunk idült gastritist (p = 0,032). A Helicobacter pylori-fertőzöttség egyik szövettanú polip jelenlétével sem függött össze. Következtetés: Hazai betegek körében gyakoribb a gyomorpolip, mint az az irodalmi adatok alapján várható lenne. A fundusmirigypolipok gyakoribbak tartós protonpumpagátló-használó betegekben, a hyperplasticus polipok előfordulása pedig az idült gastritisek gyakoriságával mutat összefüggést. Orv. Hetil., 2013, 154, 770-774. Kulcsszavak: gyomorpolip, incidencia, etiológia, protonpumpagátló Prevalence of gastric polypoid lesions in a single endoscopic centreBackground: The prevalence of gastric polyps is unknown in Hungary. Aim: The aim of the authors was to assess the prevalence of polypoid lesions of the stomach in the endoscopic centre of the 2nd Department of Medicine, Semmelweis University. Methods: Results of upper gastrointestinal endoscopies carried out between March 2010 and June 2011 were analysed. Results: 193 cases with polyps were diagnosed in 4174 endoscopies (4.62%). Hyperplastic polyps, fundic gland polyps and malignant lesion were detected in 33.67%, 31.09% and 2.07% of the cases, respectively. Proton pump inhibitor use was more frequent among patients diagnosed with fundus gland polyps (p = 0.007), while hyperplastic polyps were diagnosed more frequently in patients with chronic gastritis (p = 0.032). Conclusions: The frequency of gastric polyps was higher than expected from data published in the literature. Longterm proton pump-inhibitor use and chronic gastritis were associated with fundus gland and hyperplastic polyps, respectively. Orv. Hetil., 2013, 154, 770-774.

show abstract

“…The importance is that COX-2 expression plays an important role in tumor enlargement, partly through enhanced angiogenesis [42] . Several prospective studies have demonstrated the regression of hyperplastic polyps after eradication of H. pylori infection [43][44][45] . However, not all hyperplastic polyps are associated with documented H. pylori infection, and there are no data demonstrating regression of hyperplastic polyps greater than 1 cm in diameter after H. pylori treatment.…”

Section: B Amentioning

confidence: 99%

Intermittent gastric outlet obstruction caused by a prolapsing antral gastric polyp

Parikh

Kelley²,

Rendón³

et al. 2010

WJGO

View full text Add to dashboard Cite

Most gastric polyps have an asymptomatic presentation and are an incidental finding on upper endoscopy. Sym ptomatic presentations can range from an ulcerated polyp leading to anemia and occult bleed to complete gastric outlet obstruction. We report a case of an 89year old woman who presented with postprandial nausea and early satiety. Her upper endoscopy revealed a 2 cm pedunculated hyperplastic polyp arising from the antrum of the stomach which was seen prolapsing into the pylorus causing intermittent gastric outlet obstruction. In the present report, we statistically analyzed 39 prolapsing gastric polyps previously reported in the English literature and demonstrate the current utility of monopolar snare polypectomy in establishing a histological diagnosis while offering simultaneous treatment. Additionally, we review the literature for the management of all hyperplastic gastric polyps in relation to advancements in digestive endoscopy.

show abstract

The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps

Cited by 58 publications

References 0 publications

Gastric polyps: analysis of endoscopic and histological features in our center

Gastric polyps: analysis of endoscopic and histological features in our center

Prevalence of gastric polypoid lesions in a single endoscopic centre

Intermittent gastric outlet obstruction caused by a prolapsing antral gastric polyp

Contact Info

Product

Resources

About