The Effect of Epinephrine and Nor-Epinephrine on the Acute Thyroid Release of Thyroid Hormones

Ackerman, Norman B.; Arons, Walter L.

doi:10.1210/endo-62-6-723

Cited by 60 publications

(16 citation statements)

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“…As for the effects of epinephrine on thyroidal hormone secretion in man, no studies have come to our attention. Animal studies, employing direct sampling of thyroidal vein blood, show epinephrine to increase (22) or not to affect (23,24) thyroidal hormone secretion rate. In any case, in the present study the decline in serum T4 concentration was progressive, continuing during the postcontrol period, and therefore is not easily attributable to an epinephrine effect.…”

Section: Discussionmentioning

confidence: 98%

Effect of epinephrine on the peripheral metabolism of thyroxine

Hays¹

1969

J. Clin. Invest.

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A B S T R A C T 10 normal young men received repository epinephrine repeatedly for 4 days during the course of a radiothyroxine (radio-T4) disappearance curve. During epinephrine administration, serum radio-T4 disappearance rate (k) slowed abruptly, fecal clearance decreased, urinary clearance was initially unchanged but later decreased slightly, volume of thyroxine distribution decreased, and external radioactivity over the liver remained unchanged. Beginning on day 2 of epinephrine and persisting at least 1 day after epinephrine was discontinued, serum thyroxine-binding globulin (TBG) maximal binding capacity increased, thyroxine-binding prealbumin (TBPA) maximal binding capacity decreased, and free T4 iodine decreased. Stable serum T4 iodine decreased during the experiment. Three indexes, namely the free T4 iodine, the reciprocal of TBG capacity, and the urinary radio-T4 "clearance" changed in parallel, suggesting that the increase in TBG capacity was responsible for a delayed decrease in radio-T4 metabolism. However, these changes were temporally dissociated from the decrease in k, which began and ended abruptly with initiation or discontinuing of epinephrine administration. This dissociation is unexplained, but may be caused by alterations in T4 binding in tissue sites.

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Section: Discussionmentioning

confidence: 98%

Effect of epinephrine on the peripheral metabolism of thyroxine

Hays¹

1969

J. Clin. Invest.

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“…Insulin has been shown to enhance glucose uptake comparable to that of TSH in vitro ( 11 ). Epinephrine, norepinephrine, and acetylcholine have been found to increase the release of radioiodine from the thyroid in vivo (41,42), and recently it was demonstrated that these agents increase thyroidal glucose metabolism in vitro, similarly to TSH (43,44). In these studies, insulin, epinephrine, and acetylcholine had no stimulatory effect on proteolysis.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Thyrotropin-Induced Proteolysis in the Thyroid Gland*

Poffenbarger¹,

Powell²,

Deiss³

1963

J. Clin. Invest.

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Numerous studies, both in vivo and in vitro, have been designed to define the biochemical events influenced by the action of thyrotropin (TSH) on the thyroid gland. In vivo experiments have shown that this hormone stimulates growth of the follicular epithelium, trapping of inorganic iodide, biosynthesis of hormonal iodine, turnover of thyroglobulin, and release of inorganic iodide and hormonal iodine. The latter action has received much attention because of its relevance to the concentration of circulating thyroid hormone and because of the promptness of this response in vivo. De Robertis demonstrated an increase in intrafollicular proteolytic activity after administration of TSH to rats (1). Keating, Rawson, Peacock, and Evans (2) noted loss of radioiodine from the chick thyroid after TSH administration. Similar results have been observed in other laboratory animals (3, 4). The administration of TSH to euthyroid humans also results in prompt release of radioiodine from the thyroid (5-7), occurring 90 minutes after intramuscular inj ection in one study (7).In vitro techniques have permitted investigation in a more rigidly controlled environment. Such observations on the effect of TSH added to thyroid tissue have confirmed the stimulus to the trapping of iodide (8, 9). TSH in vitro has also been shown to enhance certain parameters of intermediary metabolism such as carbon-1 oxidation of glucose (10, 11), phospholipid synthesis (12), oxygen consumption, lipogenesis from labeled glucose, incorporation of inositol into phospholipid (13), and the level of triphosphopyridine nucleotide (14). Few

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“…Brown-Grant & Gibson (1956) reported that intravenous infusion of 2-4 ,ug/min of adrenaline bitartrate produced a complete inhibition of the uptake of 131I by the thyroid of the rabbit. In view of the above findings it is surprising that Ackerman & Arons (1958) report that adrenaline infusion in dogs results in a marked increase in secretion of thyroid hormone. S6derberg (1958) found that small doses of adrenaline or noradrenaline in rabbits andcats pre-treated with TSH evoke a transient (about 1 min) increase in thyroid secretion, though large doses of these hormones were inhibiting.…”

Section: The Effect Of Electrical Stimulation Of the Hypothalamusmentioning

confidence: 97%

“…The figure for this latent period in rabbits, given by S6der-berg (1958), of 5-30 min is probably more exact owing to the method used for collecting blood samples. Ackerman & Arons (1958) report a latent period of 15-20 min in the dog. Comparison may also be made with the time relations (latent period about 3 hr) of the thyroid inhibition which follows injection of thyroxine or application of a stressful stimulus (Brown-Grant, von Euler et al 1954;.…”

Section: The Effect Of Electrical Stimulation Of the Hypothalamusmentioning

confidence: 97%

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The acute effects of injection of thyrotrophic hormone or of electrical stimulation of the hypothalamus on thyroid activity

Campbell¹,

George²,

Harris³

1960

The Journal of Physiology

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Harris & Woods (1958) The ideal method of measuring the activity of endocrine glands appears to be to measure the rate of secretion of hormone into the blood stream; that is, to measure the hormone content of the arterial blood to, and the venous blood from, the gland and the rate of blood flow through it. Various attempts which approximate to the ideal method, in that measurements were made of the hormone content of the glandular venous blood, have been reported (adrenal medulla, Satake, Sugawara & Watanabe, 1927; Brucke, Kaindl & Mayer, 1952; Duner, 1953; Folkow & von Euler, 1954;Satake, 1955; adrenal cortex, Vogt, 1943 adrenal cortex, Vogt, , 1944Bush, 1951;Nelson & Hume, 1955;Reif & Longwell, 1958; neurohypophysis, Andersson, 1951; Ginsburgh & Heller, 1953;Fitzpatrick & Hughes, 1957; testis, Samuels, 1957). Soderberg (1958) cannulated thyroid veins in anaesthetized cats and rabbits and presented clear results on the rate of thyroid blood flow, rate of iodine uptake and rate of secretion of labelled thyroid hormone. The techniques developed by Soderberg were applicable to observations extending over periods of seconds to minutes and were used to determine the effects on thyroid blood flow and activity of interference with the nerve supply to the gland or the administration of various substances.

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The Effect of Epinephrine and Nor-Epinephrine on the Acute Thyroid Release of Thyroid Hormones

Cited by 60 publications

References 0 publications

Effect of epinephrine on the peripheral metabolism of thyroxine

Effect of epinephrine on the peripheral metabolism of thyroxine

In Vitro Thyrotropin-Induced Proteolysis in the Thyroid Gland*

The acute effects of injection of thyrotrophic hormone or of electrical stimulation of the hypothalamus on thyroid activity

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