The Effect of Enoxaparin-Containing Irrigation Fluid Used During Cataract Surgery on Postoperative Inflammation in Patients With Diabetes

İlhan, Özgür; Nilüfer, İlhan; Çoşkun, Mesut; Dağlioğlu, Mutlu Cıhan; Tuzcu, Esra Ayhan; Ayıntap, Emre; Keskın, Uğurcan; Öksüz, Hüseyın

doi:10.1016/j.ajo.2013.07.017

Cited by 12 publications

(11 citation statements)

References 24 publications

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“…Ocular inflammation was effectively induced in 12 dogs by 50 l (539.32 g) of canine lens protein solution (10.78 g/ml) injected intracamerally. Clinical signs of ocular inflammation were semiquantitatively scored on nine different occasions (1,2,3,4,5,6,12,24, and 48 hours after injection). The inflammatory response incited was immediately observed within 1 hour of the injection, with a markedly miotic pupil, and moderate amounts of protein (aqueous flare) and frank fibrin were detectable in the anterior chamber.…”

Section: Oral Efficacy Of Plga-ga 2 -Curmentioning

confidence: 99%

“…Cataract surgery results in the release of inflammatory mediators, leading to some degree of postoperative inflammation in all patients, of which patients with diabetes are at an increased risk. One of the most common postoperative complications is uveitis that can cause severe corneal edema, posterior synechia, and progression of diabetic retino pathy or neovascular glaucoma (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

Ganugula¹,

Arora²,

Lepiz

et al. 2020

Sci. Adv.

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Novel approaches circumventing blood-ocular barriers in systemic drug delivery are lacking. We hypothesize receptor-mediated delivery of curcumin (CUR) across intestinal and ocular barriers leads to decreased inflammation in a model of lens-induced uveitis. CUR was encapsulated in double-headed polyester nanoparticles using gambogic acid (GA)–coupled polylactide-co-glycolide (PLGA). Orally administered PLGA-GA2-CUR led to notable aqueous humor CUR levels and was dosed (10 mg/kg twice daily) to adult male beagles (n = 8 eyes) with induced ocular inflammation. Eyes were evaluated using a semiquantitative preclinical ocular toxicology scoring (SPOTS) and compared to commercial anti-inflammatory treatment (oral carprofen 2.2 mg/kg twice daily) (n = 8) and untreated controls (n = 8). PLGA-GA2-CUR offered improved protection compared with untreated controls and similar protection compared with carprofen, with reduced aqueous flare, miosis, and chemosis in the acute phase (<4 hours). This study highlights the potential of PLGA-GA2 nanoparticles for systemic drug delivery across ocular barriers.

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Section: Oral Efficacy Of Plga-ga 2 -Curmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

Ganugula¹,

Arora²,

Lepiz

et al. 2020

Sci. Adv.

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“…Heparin eye drops have been used to treat patients with ligneous conjunctivitis (5,000 IU/ml 6 times a day for 5 years), 159,160 paraquat-induced ocular injury, 161 posterior capsular opacification (heparin 5% ~ 5,000 IU/ml tid for 3 months) 162 and amiodaroneinduced vortex keratopathy (1,300 IU/mL tid for 3 months). 163 Heparin added into the infusion fluid has been used to reduce postoperative inflammation in patients with Diabetes 164 and in pediatric eyes undergoing cataract surgery with IOL implantation. [165][166][167] Given that heparin have been used topically and intraocularly in several settings, the use of subanticoagulant dose heparin as eye drops to treat oGVHD is likely to be safe.…”

Section: Sub-anticoagulant Dose Of Heparinmentioning

confidence: 99%

Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies

Ilangovan

Surenkhuu

et al. 2019

The Ocular Surface

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Purpose: To investigate the role of neutrophil extracellular traps (NETs) and NET-associated proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin reduces those changes. Methods: Ocular surface washings from oGVHD patients and healthy subjects were analyzed. Isolated peripheral blood human neutrophils were stimulated to generate NETs and heparinized NETs. We performed in vitro experiments using cell lines (corneal epithelial, conjunctival fibroblast, meibomian gland (MG) epithelial and T cells), and in vivo experiments using murine models, and compared the effects of NETs, heparinized NETs, NET-associated proteins and neutralizing antibodies to NET-associated proteins. Results: Neutrophils, exfoliated epithelial cells, NETs and NET-associated proteins (extracellular DNA, Neutrophil Elastase, Myeloperoxidase, Oncostatin M (OSM), Neutrophil gelatinaseassociated lipocalin (NGAL) and LIGHT/TNFSF14) are present in ocular surface washings (OSW) and mucocellular aggregates (MCA). Eyes with high number of neutrophils in OSW have more severe signs and symptoms of oGVHD. NETs (and OSM) cause epitheliopathy in murine corneas. NETs (and LIGHT/TNFSF14) increase proliferation of T cells. NETs (and NGAL) inhibit proliferation and differentiation of MG epithelial cells. NETs enhance proliferation and myofibroblast transformation of conjunctival fibroblasts. Sub-anticoagulant dose Heparin (100 IU/mL) dismantles NETs and reduces epithelial, fibroblast, T cell and MG cell changes induced by NETs.

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“…Clinical trials suggest LMWHs as promising treatment options for inflammatory disorders. For example, children and diabetic patients undergoing cataract surgery were prescribed enoxaparin to reduce the incidence of inflammatory syndrome ( Ilhan et al, 2013 ). Our study found that LMWH can play a strong anti-inflammatory role in acute sinusitis.…”

Section: Discussionmentioning

confidence: 99%

Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

Jiao

et al. 2021

Front. Pharmacol.

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Introduction: Low molecular weight heparin (LMWH), a natural sulfated glycosaminoglycan with an affinity for proangiogenic factors, is produced by chemical or enzymatic depolymerization of unfractionated heparin (UFH). Known for its anticoagulant effects, LMWH has recently been reported to have a strong anti-inflammatory effect on colitis, myocarditis, and airway inflammation. However, as a newly-developed drug, its anti-inflammatory mechanism in upper respiratory tract inflammation has not been well-studied.Methods: SD rats were randomly divided into control and experimental groups. The experimental group was established by building an acute nasal sinusitis model with expansion sponges mixed with Streptococcus pneumoniae. Then the experimental group rats were subcutaneously injected with different concentrations of LMWH. After seven consecutive days of injection, some rats were sacrificed, and blood and nasal mucosa samples were taken to determine their inflammation status. The remaining acute sinusitis rats were randomly selected for a week of nasal irrigation with normal saline or saline mixed with different concentrations of LMWH. One week later, rats were sacrificed, and samples of blood and nasal mucosa were taken to determine the inflammation status.Results: Rat nasal mucosa in the model group had obvious inflammation. The degree of nasal mucosa inflammation damage in the experimental group was lower than in the experimental control group, proving that LMWH has a protective effect on the nasal mucosa and that the effect correlates with dosage. Irrigation of the nose with saline mixed with LMWH can improve the anti-inflammatory effect. Protein related to the TLR4-MyD88-NF-κB signaling pathway was activated in the acute sinusitis rat model, and LMWH can significantly inhibit its expression.Conclusion: This is the first report of the anti-inflammatory effect of LMWH in acute upper respiratory tract inflammation, together with an explanation of its anti-inflammatory mechanism. The findings contribute a theoretical basis for its potential anti-tumor effect.

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The Effect of Enoxaparin-Containing Irrigation Fluid Used During Cataract Surgery on Postoperative Inflammation in Patients With Diabetes

Cited by 12 publications

References 24 publications

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies

Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

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