The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence

Afsar, Barış; Afşar, Rengin Elsürer; Çöpür, Sidar; Sag, Alan A.; Ortíz, Alberto; Kanbay, Mehmet

doi:10.1017/s000711452000358x

Cited by 4 publications

(3 citation statements)

References 112 publications

(137 reference statements)

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“…Current mechanistic concepts suggest that CR-mediated cellular resistance is based on reduced IGF-1/Insulin signaling [ 19 ], activation of AMPK [ 52 ], and an inhibition of the mammalian target of rapamycin (mTOR) [ 53 ]. In the nematode, Lucanic et al concluded that the TOR-pathway might control NAE levels in response to nutrient intake and that reduced NAE signaling is a component of CR-mediated lifespan extension [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury

Hoyer-Allo

Späth

Hanßen

et al. 2021

IJMS

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Acute kidney injury (AKI) is a frequent and critical complication in the clinical setting. In rodents, AKI can be effectively prevented through caloric restriction (CR), which has also been shown to increase lifespan in many species. In Caenorhabditis elegans (C. elegans), longevity studies revealed that a marked CR-induced reduction of endocannabinoids may be a key mechanism. Thus, we hypothesized that regulation of endocannabinoids, particularly arachidonoyl ethanolamide (AEA), might also play a role in CR-mediated protection from renal ischemia-reperfusion injury (IRI) in mammals including humans. In male C57Bl6J mice, CR significantly reduced renal IRI and led to a significant decrease of AEA. Supplementation of AEA to near-normal serum concentrations by repetitive intraperitoneal administration in CR mice, however, did not abrogate the protective effect of CR. We also analyzed serum samples taken before and after CR from patients of three different pilot trials of dietary interventions. In contrast to mice and C. elegans, we detected an increase of AEA. We conclude that endocannabinoid levels in mice are modulated by CR, but CR-mediated renal protection does not depend on this effect. Moreover, our results indicate that modulation of endocannabinoids by CR in humans may differ fundamentally from the effects in animal models.

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Section: Discussionmentioning

confidence: 99%

Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury

Hoyer-Allo

Späth

Hanßen

et al. 2021

IJMS

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“…In addition, in CKD patients, there is also an increased risk for osteoporosis and fracture risk associated with MBD. Bearing in mind that bone pathophysiology in CKD patients is quite different from healthy individuals, until specific studies are conducted to clarify the impact of CR on bone health in the scenario of CKD, CR should be considered with caution in CKD patients [8]. Moreover, when planning CR in a CKD patient, mostly in the earlier CKD stages, it would be necessary to assess bone status and to follow up the progression of bone parameters (e.g., BMD) in order to adjust caloric intake based on their evolution…”

Section: Caloric Intake and Metabolic Bone Disease (Mbd)mentioning

confidence: 99%

Caloric Intake in Renal Patients: Repercussions on Mineral Metabolism

et al. 2020

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The aim of this paper is to review current knowledge about how calorie intake influences mineral metabolism focussing on four aspects of major interest for the renal patient: (a) phosphate (P) handling, (b) fibroblast growth factor 23 (FGF23) and calcitriol synthesis and secretion, (c) metabolic bone disease, and (d) vascular calcification (VC). Caloric intake has been shown to modulate P balance in experimental models: high caloric intake promotes P retention, while caloric restriction decreases plasma P concentrations. Synthesis and secretion of the phosphaturic hormone FGF23 is directly influenced by energy intake; a direct correlation between caloric intake and FGF23 plasma concentrations has been shown in animals and humans. Moreover, in vitro, energy availability has been demonstrated to regulate FGF23 synthesis through mechanisms in which the molecular target of rapamycin (mTOR) signalling pathway is involved. Plasma calcitriol concentrations are inversely proportional to caloric intake due to modulation by FGF23 of the enzymes implicated in vitamin D metabolism. The effect of caloric intake on bone is controversial. High caloric intake has been reported to increase bone mass, but the associated changes in adipokines and cytokines may as well be deleterious for bone. Low caloric intake tends to reduce bone mass but also may provide indirect (through modulation of inflammation and insulin regulation) beneficial effects on bone. Finally, while VC has been shown to be exacerbated by diets with high caloric content, the opposite has not been demonstrated with low calorie intake. In conclusion, although prospective studies in humans are needed, when planning caloric intake for a renal patient, it is important to take into consideration the associated changes in mineral metabolism.

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“…Dietary modification, an essential element of diabetes therapy and its associated problems, involves the strategic adjustment of nutritional consumption [11]. Caloric restriction (CR) is a common dietary modification, and has the potential to mitigate several chronic illnesses, including cancer, diabetes, and chronic kidney disease (CKD) [12]. However, the increased hunger caused by CR and low adherence limit the clinical use of CR, resulting in focusing on searching for other dietary modifications.…”

Section: Introductionmentioning

confidence: 99%

A late eating midpoint is associated with increased risk of diabetic kidney disease: a cross-sectional study based on NHANES 2013–2020

Lu,

Cang,

Liu

et al. 2024

Nutr J

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Background Modifying diet is crucial for diabetes and complication management. Numerous studies have shown that adjusting eating habits to align with the circadian rhythm may positively affect metabolic health. However, eating midpoint, eating duration, and their associations with diabetic kidney disease (DKD) are poorly understood. Methods The National Health and Nutrition Examination Survey (2013–2020) was examined for information on diabetes and dietary habits. From the beginning and ending times of each meal, we calculated the eating midpoint and eating duration. Urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 were the specific diagnostic criteria for DKD. Results In total, details of 2194 subjects with diabetes were collected for analysis. The overall population were divided into four subgroups based on the eating midpoint quartiles. The prevalence of DKD varied noticeably (P = 0.037) across the four categories. When comparing subjects in the second and fourth quartiles of eating midpoint to those in the first one, the odds ratios (ORs) of DKD were 1.31 (95% CI, 1.03 to 1.67) and 1.33 (95% CI, 1.05 to 1.70), respectively. And after controlling for potential confounders, the corresponding ORs of DKD in the second and fourth quartiles were 1.42 (95% CI, 1.07 to 1.90) and 1.39 (95% CI, 1.04 to 1.85), respectively. Conclusions A strong correlation was found between an earlier eating midpoint and a reduced incidence of DKD. Eating early in the day may potentially improve renal outcomes in patients with diabetes.

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The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence

Cited by 4 publications

References 112 publications

Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury

Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury

Caloric Intake in Renal Patients: Repercussions on Mineral Metabolism

A late eating midpoint is associated with increased risk of diabetic kidney disease: a cross-sectional study based on NHANES 2013–2020

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