The Effect of Endoscopic Olfactory Cleft Opening on Obstructed Olfactory Cleft Disease

Jiang, Rong–San; Liang, Kai‐Li

doi:10.1155/2020/8073726

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…The MCA 2 of both nostrils was averaged to give a mean MCA 2 (cm 2 ). The smell function was evaluated using the phenyl ethyl alcohol (PEA) threshold test [ 19 ] and the traditional Chinese version of the University of Pennsylvania Smell Identification Test (UPSIT-TC) (Sensonics, Inc., Hadden Heights, NJ, USA) [ 20 ]. The saccharine transit test involves placing saccharine granules under the head of the inferior turbinate in the more severely affected nostril.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Safety of Xylitol Nasal Irrigation after Functional Endoscopic Sinus Surgery: A Randomized Controlled Study

Jiang,

Chiang,

Liang

2024

Biomedicines

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Xylitol is considered a naturally occurring antibacterial agent. It is generally believed to enhance the body’s own innate bactericidal mechanisms. It also provides anti-adhesive effects against both Streptococcus pneumoniae and Haemophilus influenza. This study was performed to evaluate the efficacy and safety of xylitol nasal irrigation in the postoperative care of functional endoscopic sinus surgery (FESS). Patients with chronic rhinosinusitis who received FESS were recruited and randomly assigned to two groups at one month post-surgery. Thirty-five patients in the xylitol group received 400 mL of 5% xylitol nasal irrigation daily for 2 months, while another 35 in the normal saline (NS) group received 400 mL of NS nasal irrigation daily for 2 months. Prior to FESS, as well as before and after nasal irrigation, sinonasal symptoms were assessed through the 22-item Sino-Nasal Outcome Test Questionnaire. The patients also underwent an endoscopic examination while undergoing nasal function tests, and a cytokine measurement of the nasal lavage and a bacterial culture from the middle meatus were performed. The safety of the nasal irrigation was assessed through any self-reported adverse events, the Eustachian Tube Dysfunction Patient Questionnaire and the eustachian tube function test. The endoscopic scores and olfactory threshold significantly decreased after xylitol irrigation when compared with those before irrigation. The prevalence of Staphylococcus aureus in the nasal secretions also decreased significantly after xylitol irrigation. The amounts of Interleukin-5 and Interleukin-17A were significantly increased in the nasal lavage after xylitol irrigation. No side effects, including those related to eustachian tube function, were seen after nasal irrigation in both groups. Our results showed that xylitol nasal irrigation was both beneficial and safe during the postoperative care of FESS.

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Section: Methodsmentioning

confidence: 99%

Efficacy and Safety of Xylitol Nasal Irrigation after Functional Endoscopic Sinus Surgery: A Randomized Controlled Study

Jiang,

Chiang,

Liang

2024

Biomedicines

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“…It is well-known that complications and olfactory disruption occur after nasal surgery ( Pfaar et al, 2004 ; Alobid et al, 2013 ). The removal of lesions in the olfactory cleft (OC) aims to open the pathway to the olfactory mucosa (OM), thereby maximizing olfactory functional outcomes ( Jiang and Liang, 2020 ). However, this removal of lesions in the OC ( Hurtt et al, 1988 ; Delank and Stoll, 1998 ) or the approach of OM removal remains controversial because of the risk of iatrogenic hyposmia or anosmia secondary to OM damage.…”

Section: Introductionmentioning

confidence: 99%

Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection

et al. 2021

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Resection of the olfactory mucosa (OM) is sometimes unavoidable during surgery; however, it is not known whether the OM can completely recover thereafter. The aim of this study was to uncover whether the OM fully recovers after mucosal resection and describe the process of OM regeneration. 8-week-old male Sprague–Dawley rats (n = 18) were subjected to OM resection at the nasal septum; six rats were euthanized for histological examination 0, 30, and 90 days after surgery. Immunohistochemistry was performed to identify olfactory receptor neuron (ORN) lineage cells [mature and immature ORNs and ORN progenitors, and olfactory ensheathing cells (OECs)], as well as dividing and apoptotic cells. Squamous and respiratory metaplasia and inflammatory cell infiltration were also assessed. On day 30 after resection, the mucosa had regenerated, and mainly contained thin nerve bundles, basal cells, and immature ORNs, with a few mature ORNs and OECs. On day 90, the repaired nasal mucosa had degenerated into stratified squamous or ciliated pseudostratified columnar epithelia, with reducing ORNs. The lamina propria contained numerous macrophages. Partial regeneration was observed within 1 month after OM resection, whereas subsequent degeneration into squamous and respiratory epithelia occurred within 3 months. Given the poor persistence of ORNs and OECs, OM resection is likely to result in olfactory impairment. Overall, surgeons should be cautious not to injure the OM during surgery.

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“…1C, arrow). Endoscopic right sinus surgery was performed to remove the abscess, free the OC and perform biopsies [2]. Histological analysis confirmed the presence of filamentous bacteria grains around a sinusal foreign plant body, characteristic of Actinomyces (Grocott positive, Gram positive and Ziehl negative) (Fig.…”

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confidence: 99%