The effect of endometrial thickness on IVF/ICSI outcome

Kovács, Péter; Mátyás, Szabolcs; Boda, Krisztina; Kaali, Steven G.

doi:10.1093/humrep/deg461

Cited by 224 publications

(193 citation statements)

References 17 publications

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“…Similar findings were reported by Noyes et al [3]. Kovacs et al [4] also reported that increased endometrial thickness was significantly associated with higher pregnancy rates. In our study, no pregnancy was reported when endometrial thickness was less than 7 mm.…”

Section: Discussionsupporting

confidence: 87%

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Khan¹,

Shaikh²,

Ratnani³

2015

J Obstet Gynecol India

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About the Author AbstractPurpose To detect whether ultrasonographic parameters and Doppler analysis of uterine blood flow can be of value in the prediction of endometrial receptivity in infertile female patients undergoing embryo transfer. Methods In this study, a total of 200 women with primary infertility undergoing embryo transfer were analyzed. Transvaginal ultrasonography was done on the 10th day of the menstrual cycle. To assess the uterine receptivity, we analyzed all the ultrasonographic and Doppler parameters. The slightly modified version of Applebaum Uterine Scoring System was used. This uterine scoring system included all the following parameters: endometrial thickness, endometrial morphology, endometrial blood flow within zone 3, myometrial echogenecity, uterine artery pulsatility index (PI), end diastolic blood flow, and myometrial blood flow internal to the arcuate vessels seen on gray-scale examination. Results The pregnancy rates were higher in women with thick, distinct five-line endometrium and multifocal endometrial vascularity within zone 3. Absent endometrial flow, despite highest values for the other parameters, was associated with no conception. In our study, no pregnancy occurred with uterine PI values of more than 2.8. Absence or reversal of end diastolic blood flow was associated with no conception. A maximum score of 20 was associated with the pregnancy rate of 97.4 %, whereas scores of 13 or less resulted in no pregnancies. 123Conclusion Uterine scoring system will help to perform embryo transfers in only favorable uteri and postpone or cancel those cycles in which poor uterine score is demonstrated.

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Section: Discussionsupporting

confidence: 87%

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Khan¹,

Shaikh²,

Ratnani³

2015

J Obstet Gynecol India

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“…A number of studies have indicated a higher pregnancy rate at a partic- ular endometrial thickness (29)(30)(31)(32)(33), while alternative studies indicated no significant correlation between endometrial thickness and pregnancy rates in IVF/ICSI patients (34)(35)(36)(37)(38)(39). The present study indicated that clinical pregnancy rates following embryo transfer are positively correlated with endometrial thickness, which is consistent with previous studies (39)(40)(41).…”

Section: Discussionsupporting

confidence: 88%

“…A number of studies have evaluated the association between endometrial thickness and pregnancy rates in patients undergoing assisted reproductive technology; however, the results remain controversial (29)(30)(31)(32)(33)(34)(35)(36)(37)(38). A number of studies have indicated a higher pregnancy rate at a partic- ular endometrial thickness (29)(30)(31)(32)(33), while alternative studies indicated no significant correlation between endometrial thickness and pregnancy rates in IVF/ICSI patients (34)(35)(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Yin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the association between follicular fluid (FF) levels of high-mobility group box 1 (HMGB1) protein and the reproductive outcome in patients undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). FF samples were collected from the ovarian follicles (≥14 mm) of 143 infertile patients that had undergone IVF/ICSI, and the HMGB1 expression levels were determined using ELISA. Spearman's correlation and receiver operating characteristic (ROC) curve analysis were applied to analyze the results. Significantly increased levels of HMGB1 protein (7.38±2.02 vs. 6.14±2.52 ng/ml; P<0.01), endometrial thickness on the day of human chorionic gonadotropin (hCG) administration (10.3±1.3 vs. 9.7±1.7 mm; P<0.01) and retrieved oocyte counts (11.68±6.51 vs. 11.00±6.34; P<0.01) were observed in the pregnant group when compared with the non-pregnant group. Conversely, the level of luteinizing hormone on the day of hCG administration was significantly reduced in the pregnant group compared with the non-pregnant group (0.92±1.78 vs. 1.78±2.03 pmol/l, P<0.01). The ROC curve indicated a significant association between the FF level of HMGB1 protein and the pregnancy rate, with an area under the ROC curve of 0.673 (0.581-0.765; P<0.01). In addition, the HMGB1 protein level was shown to have a significant positive correlation with the endometrial thickness (r=0.170; P<0.05). Therefore, the present study indicated that the FF levels of HMGB1 protein are increased in pregnant patients and are positively correlated with endometrial thickness. Thus, FF levels of HMGB1 may be a useful factor for predicting the outcome of IVF/ICSI treatments.

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“…Endometrial thickness has been reported to be one of the most important factors for success in ART. Zhang et al [12] reported a significant difference in the pregnancy rate in patients with an endometrial thickness above and below 9 mm, whereas Kovacs et al [13] and Richter et al [14] showed a gradual increase in the implantation rate with increasing endometrial thickness. In the present study, none of the patients whose endometrial thickness was <7 mm achieved a live-birth (data not shown).…”

Section: Discussionmentioning

confidence: 99%

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Fujimoto

Ichinose

Harada

et al. 2014

J Assist Reprod Genet

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Purpose To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). Methods The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. Results There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. Conclusions Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.

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The effect of endometrial thickness on IVF/ICSI outcome

Abstract: Increased endometrial thickness is associated with higher pregnancy rates. However, neither attainment of pregnancy nor pregnancy outcome was predicted by endometrial thickness alone.

Cited by 224 publications

References 17 publications

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Ultrasonography and Doppler Study to Predict Uterine Receptivity in Infertile Patients Undergoing Embryo Transfer

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

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