The Effect of Endometrial Scratch on Pregnancy Rate in Women with Previous Intrauterine Insemination Failure: a Systematic Review and Meta-analysis of Randomized Controlled Trials

Baradwan, Saeed; Alshahrani, Majed Saeed; AlSghan, Rayan; Alkhamis, Waleed H.; Alsharif, Saud Abdullah; Alanazi, Gharam Abdulrahman; Abdelwahed, Rania Mahfouz; Alkholy, Eman A.; Fouad, Mahmoud; Saleh, Mahmoud M.; Abdelati, Manal; Alazazy, Hosam Eldin Mohamad; Elsenity, Mohamed; Abdelhakim, Ahmed Mohamed; Mohamed, Mohamed Abdelsattar; Abbas, Ahmed M.; Mojahed, Eman M.

doi:10.1007/s43032-022-01081-z

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Clinical Significance In Reproductive Medicine1

Balanced Inflammatory Micromilieu1

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2023

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“…For a more detailed insight, many reviews and meta-analytic publications were published concerning this topic, which seems to be declining but is still under a heated debate (reviewed i.a. in [ 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 ]).…”

Section: Clinical Significance In Reproductive Medicinementioning

confidence: 99%

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Immune Cell Functionality during Decidualization and Potential Clinical Application

Stope

Mustea

Sänger

et al. 2023

Life

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Due to a vast influx in the secretory phase of the menstrual cycle, leukocytes represent 40–50% of the decidua at the time of implantation. Their importance for the implantation, maintenance of pregnancy, and parturition are known yet not fully understood. Thus, in idiopathic infertility, decidual immune-related factors are speculated to be the cause. In this review, the immune cell functions in the decidua were summarized, and clinical diagnostics, as well as interventions, were discussed. There is a rising number of commercially available diagnostic tools. However, the intervention options are still limited and/or poorly studied. In order for us to make big steps towards the proper use of reproductive immunology findings, we need to understand the mechanisms and especially support translational research.

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Section: Clinical Significance In Reproductive Medicinementioning

confidence: 99%

“…Recurrent implantation failure Thin endometrial lining Scratching [171][172][173][174][175][176][177][178], PRP infusion [183][184][185][186][187][188], G-CSF [267,269,270] Wound-healing-like Decidualization, Regeneration…”

Section: Balanced Inflammatory Micromilieumentioning

confidence: 99%