The effect of endogenous antioxidant glabridin on oxidized LDL

Abstract

Oxidative stress is thought to play a central role in low-density lipoprotein (LDL) oxidation, and the oxidative modification of LDL is thought to be a key factor during early atherogenesis. Therefore, the prevention of LDL oxidation by antioxidants might arrest the progression of atherosclerosis. This study was conducted to determine the effect of glabridin, a natural polyphenolic isoflavone antioxidant isolated from licorice root, on LDL oxidation. The determination of the extent of LDL oxidation was accomplished by measuring the formation of thiobarbituric acid reactive substances (TBARS). The oxidative stress level was assessed using a FORM system/CR 3000 instrument. After the oral administration of a glycyrrhizin-free licorice-root methanol extract (containing glabridin 60 mg) to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation decreased by 20%. We conclude that the dietary consumption of glabridin can partially protect LDL from oxidation.

Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats

“…Glabridin, a natural polyphenolic isoflavone antioxidant from licorice root extract in HMF possesses potent free radical scavenging activity that could promote a decrease in lipid peroxidation and could protect LDL from oxidation [ 93 ]. This would occur via a direct interaction with the lipoprotein and/or an indirect effect through accumulation in arterial macrophages.…”

Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis

“…During atherosclerosis, smooth muscle cells become activated by oxLDL, start to proliferate, and migrate into the intima of the arterial wall where they form foam cells [2]. Many studies have shown that increase of oxLDL have significant roles in the induction of oxidative stress related changes [3]. Hypercholesterolemia and increased oxidative stress have been involved in the development of atherosclerosis [4,5].…”

A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity

“…Honda and colleagues suggest that a decrease in abdominal adipose tissue weight may be mediated by the transcriptional regulation of SREBP-1c and PPAR-alpha in the liver [4]. Aside from the potential effects of LFO on adipose tissue accumulation, a flavonoid component of the licorice root, glabridin, has been shown to have antioxidant properties [5], which may assist in attenuating lipid peroxidation.…”