The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor

Ishihara, Akinori; Nishiyama, Norihito; Sugiyama, Shunsuke; Yamauchi, Kiyoshi

doi:10.1016/s0016-6480(03)00197-7

Cited by 125 publications

(44 citation statements)

References 46 publications

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“…We found that administration of malathion to male rats by oral gavage resulted in adverse effects that included significant decrease in the final body weights and testis weights, sperm counts, motility, and increased rates of sperm dysmorphology. These results are consistent with the published data which showed that malathion has a disruptor effect on sperm count and decreases the percentage of motile sperm of Hormone levels and relevant enzymes have been reported to be associated with the reproductive functions [Ishihara et al, 2003;Vidair, 2004]. Therefore, we examined the serum hormone (LH, FSH and T) levels and found an inhibitory effect on these hormones by malathion.…”

Section: Discussionsupporting

confidence: 92%

“…Animal study suggested that inhibition of enzymes leads to age-dependent neurologically disorders neurological and behaviour disorders [Vidair, 2004]. Moreover, many OP pesticides including malathion have been identified as endocrine disruptors (ED) which can interfere with hormone levels through binding to and activating estrogen, androgen and other hormone receptors [McKinlay et al,2008; A c c e p t e d M a n u s c r i p t 5 hormone receptors [Ishihara et al, 2003]. Other general toxicities of malathion at the cellular and organ level have also been identified by in vitro methods [Jira et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

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Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

Geng

Shao

Zhang

et al. 2015

Environmental Toxicology and Pharmacology

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Please cite this article as: Geng, X., Shao, H., Zhang, Z., Ng, J.C., Peng, C.,Malathioninduced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats, Environmental Toxicology and Pharmacology (2015), http://dx.doi.org/10. 1016/j.etap.2015.01.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Malathion caused the reduction in the sperm counts and motility. The reduced body and testis weights were coupled with mild to severe degenerative changes in seminiferous tubules. We Page 3 of 32 A c c e p t e d M a n u s c r i p t 3 found malathion at 54 mg/kg increased spermatogenic apoptosis rate which was confirmed by changes in protein expression of Bax and Bcl-2. The activities of testicular enzymes including ACP, LDH and γ-GT were significantly altered with the reduced level of reproductive hormones such LH, FSH and T. These results indicate that malathion can elicit deleterious effects on reproductive system of rats. The abnormal levels of hormones and apoptotic proteins induced by malthion may play important roles.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

Geng

Shao

Zhang

et al. 2015

Environmental Toxicology and Pharmacology

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“…These studies revealed that most EDCs tested at micromolar concentrations did not compete with T 3 binding to TR but did compete with T 3 binding to TTR (Yamauchi et al 2000, Ishihara et al 2003a, 2003b. This was in contrast to the steroid system where a number of chemicals are capable of competing with estrogen and progesterone binding to their respective receptors (Tran et al 1996, Matthews et al 2000.…”

Section: Introductionmentioning

confidence: 95%

Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response

Shimada¹,

Yamauchi²

2004

Journal of Endocrinology

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We characterized the 3,5,3 --triiodothyronine (T 3 )-uptake system on the plasma membrane of Rana catesbeiana tadpole red blood cells (RBCs) 125 I]T 3 uptake by 2-fold at 3·2 µM. When RBCs were cultured with 10 nM T 3 at 25 C for 2 days in the presence of monodansylcadaverine, ethinylestradiol, ioxynil or dicofol at the defined concentrations, these compounds inhibited significantly the induction of the thyroid hormone receptor gene by T 3 . However, not all chemicals competed with T 3 binding to the receptor at the same concentrations. Our results raise the possibility that the T 3 -uptake system on the plasma membrane of the tadpole RBCs could be a candidate target site for some EDCs and can modulate cellular T 3 response.

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“…To test whether a chemical disrupts the hypothalamus-pituitary-thyroid axis (HPT-axis), a limited number of screening assays are available. EDSTAC recommends the following in vivo assays: The frog metamorphosis assay, The adult male assay (to detect anti-androgenic effects, full thyroid and reproductive hormone screen) and the Japanese quail has been proposed as an in vivo model for action on TH-binding proteins (Ishihara et al, 2003).…”

Section: Assays To Detect Chemicals With Effects On the Thyroidmentioning

confidence: 99%

OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of substances with endocrine disrupting properties

2004

TemaNord

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The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor

Cited by 125 publications

References 46 publications

Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response

OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of substances with endocrine disrupting properties

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