The Effect of Ellagic Acid and Sodium Fluoride Intake on Total Sialic Acid Levels and Total Oxidant/Antioxidant Status in Mouse Testicular Tissue

Kaya, İnan; Deveci, Hacı; Ekinci, Umit Volkan; Kaya, Müge Mavioğlu; Alpay, Merve

doi:10.9734/arrb/2015/19327

Cited by 2 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in TSA levels may be due to the release of sialic acids in the membrane of cells damaged by oxidative stress developing due to fluorosis (Ozcelik et al, 2014;Koçak et al, 2020b). There are studies indicating that serum TSA (Jha et al, 1982;Ciftci et al, 2010;Doğan et al, 2016), PSA (Sharma, 1983) and testicular TSA (Kaya et al, 2015) levels decrease in fluorosis patients.…”

Section: Resultsmentioning

confidence: 99%

“…Chronic fluorine toxicity is mainly observed in dental and bone tissues. However, in many experimental and epidemiological studies conducted in recent years, metabolic, functional and structural damages caused by chronic fluorosis in soft tissues and organs including kidney, liver, muscle, testicle and nervous tissue have been reported (Kaya et al, 2015;Wei et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…Sialic acid is an important parameter for the diagnosis of fluorosis in both humans and animals (Kaya et al, 2015). Oto et al (2016), in the study in which they investigated the effect of resveratrol on serum TSA and LSA in experimental fluorosis, determination that TSA and LSA levels were significantly increased in the fluorosis group and resveratrol was not effective in decreasing this increase.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Chitosan and Chitosan Oligosaccharide on Serum and Tissue Sialic Acid Levels in Experimental Fluorosis

Özdek

Değer

2021

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

Bu çalışmada deneysel florozisli ratlarda, kitosan (CH) ve kitosan oligosakkaritin (COS), serum ve dokularda (karaciğer, böbrek, beyin ve testis) toplam siyalik asit (TSA) düzeyine etkisi araştırılmıştır. Gruplar kontrol, sodyum florür (NaF), NaF + kitosan (NaF + CH), NaF + kitosan oligosakkarit (NaF + COS), kitosan (CH) ve kitosan oligosakkarit (COS) olarak oluşturuldu. NaF gruplarının içme suyu 100 ppm sodyum florür konsantrasyonunda hazırlandı. Deney gruplarında, doksan gün süreyle kitosan ve kitosan oligosakkarit 250 mg/kg dozunda oral yolla uygulandı. Çalışma sonunda serum ve karaciğer, böbrek, beyin ve testis doku homojenizatlarının TSA düzeyi spektrofotometrik yöntemle belirlendi. Florür uygulanan grupta (NaF), kontrol grubu ile karşılaştırıldığında, serum, karaciğer, böbrek, beyin ve testis dokularında TSA düzeylerinin arttığı görüldü (p<0.05). NaF grubuna göre, NaF+CH grubunda serum seviyelerinde, NaF+COS grubunda ise serum, karaciğer ve böbrek dokularında belirgin düşüş vardı. Beyin dokusu sialik asit düzeyi açısından kontrol ve deney grupları arasında fark olmadığı belirlendi (p>0.05). Sonuç olarak, flor toksikasyonunun, serum ve dokularda hücre hasarına neden olarak, TSA düzeylerinde artışa neden olduğu düşünülebilir. Sunulan çalışmada, CH ve COS'un TSA seviyelerini düşürdüğü gösterilmiştir. Ayrıca bu çalışmada, COS'un TSA seviyesini azaltmada daha etkili olduğu görüldü.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Chitosan and Chitosan Oligosaccharide on Serum and Tissue Sialic Acid Levels in Experimental Fluorosis

Özdek

Değer

2021

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

show abstract

“…Moreover, the most crucial feature of the antioxidant defense system is that all synergistic components assign against reactive oxygen species for homeostasis. Combined oxidants/antioxidants are more effective than existing alone in the blood ( Kaya et al, 2015 ). Significant increases in SOD, catalase, GSH, and GPx levels were observed in GBTF Group and GBTP Group.…”

Section: Discussionmentioning

confidence: 99%

Development of Cholesterol-Lowering and Detox Formulations Using Bentonite and Herbal Ingredients

et al. 2021

View full text Add to dashboard Cite

Detoxification enzymes involved in human metabolism works to minimize the potential xenobiotic-induced damage constantly. Studies have revealed that toxin accumulation plays an important role in the etiology of cardiovascular disease. This study has been designed to provide evidence of medicinal use of bentonite, turmeric (Curcuma longa L.), grape (Vitis vinifera L.) seed, flaxseed (Linum usitatissimum L.), and psyllium (Plantago ovata L.) as detoxification and cholesterol-lowering agents using a hypercholesterolemic model in mice. The potential hypocholesterolemic effects and detoxification ability of these ingredients were evaluated at the same time: Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, glucose, aspartate aminotransferase, alanine aminotransferase, malondialdehyde, plasma total antioxidant activity, nitric acid, leptin levels and glutathione, glutathione peroxidase, lipid peroxidation, superoxide dismutase and catalase values were measured. It was determined that GBTF group (grape seed extract, bentonite, turmeric, and flaxseed), GBTP group (grape seed extract, bentonite, turmeric, and psyllium), and GBT group (grape seed extract, bentonite, and turmeric) of the tested materials decreased the serum total cholesterol concentration by 64.8, 57.5, and 48.9%, respectively, in mice fed a high cholesterol diet. In addition, it was determined that some detoxification parameters such as superoxide dismutase, catalase, glutathione, and glutathione peroxidase were statistically significantly reversed in GBTF, GBTP, and GBT groups. Flaxseed, psyllium, and bentonite clay did not show significant effects in reducing total cholesterol; however, GBTF, GBTP, and GBT groups interventions had a significant effect in reducing total cholesterol levels. Moreover, it was observed that adding flaxseed or psyllium to the GBT group increased the cholesterol-lowering effect. Therefore, it can be thought that this significant effect is due to the synergistic effect of the raw materials. When the results obtained were evaluated, it was seen that the cholesterol-lowering and detoxification effects of the combinations were higher than from the effect of natural material used alone. As a result, combinations of some of these ingredients have a positive effect on reducing the risk of cardiovascular disease.

show abstract

The Effect of Ellagic Acid and Sodium Fluoride Intake on Total Sialic Acid Levels and Total Oxidant/Antioxidant Status in Mouse Testicular Tissue

Cited by 2 publications

References 13 publications

Effects of Chitosan and Chitosan Oligosaccharide on Serum and Tissue Sialic Acid Levels in Experimental Fluorosis

Effects of Chitosan and Chitosan Oligosaccharide on Serum and Tissue Sialic Acid Levels in Experimental Fluorosis

Development of Cholesterol-Lowering and Detox Formulations Using Bentonite and Herbal Ingredients

Contact Info

Product

Resources

About