The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum

Kim, Seung-Tae; Moon, Woongjoon; Chae, Younbyoung; Kim, Youn Jung; Lee, Hyejung; Park, Hi-Joon

doi:10.1007/s12576-009-0061-7

Cited by 45 publications

(36 citation statements)

References 33 publications

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“…Acupoint GB34, located at the point of intersection of lines from the anterior borders to the head of the fibula ( Figure 1) as described (World Health Organization Western Pacific Region, 2008;Yin et al, 2008), was reported to exert the highest neuroprotective effect among several candidate acupoints based on immunohistochemical staining of tyrosine hydroxylase (TH)positive dopaminergic neurons and Nissl staining (Jeon et al, 2008;Kim et al, 2009). Acupuncture treatment was performed at GB34, 2 hr after each MPTP injection, and continued daily until 7 days after the final MPTP injection (Figure 1 [b]).…”

Section: Acupuncture Treatmentmentioning

confidence: 99%

Phosphatidylinositol 3-kinase/Akt Signaling Pathway Mediates Acupuncture-Induced Dopaminergic Neuron Protection and Motor Function Improvement in a Mouse Model of Parkinson's Disease

Kim¹,

Kim²,

Doo³

et al. 2011

International Journal of Neuroscience

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It has been reported that acupuncture treatment reduced dopaminergic neuron degeneration in Parkinson's disease (PD) models. However, the mechanistic pathways underlying, such neuroprotection, are poorly understood. Here, we investigated the effects and the underlying mechanism of acupuncture in a mouse model of PD using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). First, we observed that MPTP-induced impairment of Akt activation, but not MPTP-induced c-Jun activation, was effectively restored by acupuncture treatment in the substantia nigra. Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement. Our results provide evidence that PI3K/Akt signaling pathway may play a central role in the mechanism underlying acupuncture-induced benefits in Parkinsonian mice.

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Section: Acupuncture Treatmentmentioning

confidence: 99%

Phosphatidylinositol 3-kinase/Akt Signaling Pathway Mediates Acupuncture-Induced Dopaminergic Neuron Protection and Motor Function Improvement in a Mouse Model of Parkinson's Disease

Kim¹,

Kim²,

Doo³

et al. 2011

International Journal of Neuroscience

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“…Acupuncture point GB34 has been used to treat movement disorders in traditional East Asian medicine, and recent neuroimaging studies also discuss its effects on motor function (Chae et al, 2009; Huang et al, 2010; Na et al, 2009). Moreover, it also showed effective function on Parkinson’s disease mouse model in our previous research (Jeon et al, 2008; Kim et al, 2010, 2011a,b). The point is located at the intersection of the anterior and posterior margin of the fibular head.…”

Section: Methodsmentioning

confidence: 61%

Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of l-dopa by normalizing Parkinson's disease-induced neurochemical imbalance

et al. 2014

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This study first showed the behavioural benefits of novel combination therapy of l-dopa with acupuncture on Parkinson’s disease, and its underlying mechanisms within basal ganglia. The previous study reported that acupuncture may improve the motor function of a Parkinson’s disease (PD) mouse model by increasing the dopamine efflux and turnover ratio of dopamine. Hence, we hypothesised that combining l-dopa with acupuncture would have a behavioural benefit for those with PD. We performed unilateral injections of 6-OHDA into the striatum of C57Bl/6 mice to model hemi-Parkinsonian attributes. To test motor function and dyskinetic anomalies, we examined cylinder behaviour and abnormal involuntary movement (AIM), respectively. We found that (1) a 50% reduced dose of l-dopa (7.5 mg/kg) combined with acupuncture showed an improvement in motor function that was comparable to mice given the standard dose of l-dopa treatment (15 mg/kg) only, and that (2) the combination treatment (l-dopa +acupuncture) was significantly superior in reducing AIM scores when equivalent doses of l-dopa were used. The combination treatment also significantly reduces the abnormal increase of GABA contents in the substantia nigra compared to the standard l-dopa treatment. Furthermore, abnormal expression of FosB, the immediate early gene of l-dopa induced dyskinesia (LID), was mitigated in the striatum by the combination treatment. All of these results indicate that acupuncture enhances the benefits of l-dopa on motor function with reduced dose of l-dopa and alleviating LID by normalising neurochemical imbalance within the basal ganglia.

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“…Based on the results of the previous studies on needle acupuncture. 14,15 and as it is shown in the images 1, the GV14 acupuncture point (between C7 and T1 vertebrate) was subjected to cupping ( Figure 2). …”

Section: Methodsmentioning

confidence: 99%

Cupping: a reasonable choice for attenuating morphine withdrawal symptoms in Wistar rats

Khosravi

Roostayi

Manshadi

et al. 2017

Int J Basic Clin Pharmacol

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Background: Nowadays, the sedative drugs are the main treatments to attenuate the opioid withdrawal symptoms. However, physical therapies are found a safe alternative treatment without any serious adverse effects. This study aimed to evaluate the effects of cupping treatment on the morphine withdrawal symptoms in rats.Methods: Eighty rats were divided into two main groups; treated with morphine or saline, and each group was also divided to cupping and sham cupping subgroups (with single or daily treatment). Injection of morphine and saline were done in the morphine and saline groups twice a day for nine days. On the ninth day, the naloxone was administered and the withdrawal symptoms including jumping, rearing, body grooming, abdominal writing, and wet-dog shaking were recorded for 60 minutes. Cupping or sham cupping was applied on the GV14 once before or daily after withdrawal induction in each group.Results: The results revealed that a single cupping before the withdrawal induction significantly attenuated the withdrawal symptoms in the morphine group (p<0.01).But, the daily cupping failed to decrease the withdrawal symptoms in this group. The results also indicated that the daily cupping in the saline group increased the naloxone-induced withdrawal symptoms significantly (p<0.01).Conclusions: Single session cupping before the withdrawal induction could decreased the withdrawal symptoms. This finding might be related to the modulation of GABAergic system.

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The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum

Cited by 45 publications

References 33 publications

Phosphatidylinositol 3-kinase/Akt Signaling Pathway Mediates Acupuncture-Induced Dopaminergic Neuron Protection and Motor Function Improvement in a Mouse Model of Parkinson's Disease

Phosphatidylinositol 3-kinase/Akt Signaling Pathway Mediates Acupuncture-Induced Dopaminergic Neuron Protection and Motor Function Improvement in a Mouse Model of Parkinson's Disease

Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of l-dopa by normalizing Parkinson's disease-induced neurochemical imbalance

Cupping: a reasonable choice for attenuating morphine withdrawal symptoms in Wistar rats

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