The effect of electroacupuncture on postoperative immunoinflammatory response in patients undergoing supratentorial craniotomy

Li, Guoyan; Li, Shuqin; Wang, Baoguo; An, Li-Xin

doi:10.3892/etm.2013.1225

Cited by 18 publications

(30 citation statements)

References 10 publications

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“…Treatment with TAES increased the expression levels of IL-2, IFN-γ and IL-17, and decreased IL-10 secretion; thus suggesting that TAES was able to attenuate the postoperative immune impairment of patients with lung cancer via altering the expression of Th cell-associated cytokines. The results of the present study are in line with a previous study, in which electroacupuncture was able to improve surgery-suppressed immune function (28). Furthermore, this study reported that acupuncture and TAES were able to affect the immune system of patients undergoing major abdominal surgery (28).…”

Section: Discussionsupporting

confidence: 92%

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Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Wang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. An imbalance in the various T lymphocytes, including T-helper (Th) 1 , Th 2 and Th 17 cells, and regulatory T (T reg ) cells, has been associated with immune dysfunction, and may occur following thoracotomy of patients with lung cancer. The use of transcutaneous acupoint electrical stimulation (TAES) has previously been demonstrated to exert immunoregulatory effects; therefore, the present study aimed to evaluate whether TAES was able to attenuate postoperative immune suppression in patients with lung cancer. Thoracic surgical patients with lung cancer (n=27) underwent TAES (frequency, 2/100 Hz; intensity, 4-12 mA) at the bilateral large intestine 4, pericardium 6, small intestine 3 and San Jiao 6 acupuncture points for 30 min, prior to incision, and at 20, 44, 68, 92 and 116 h following thoracotomy. The number of Th 1 , Th 2 , Th 17 and T reg cells, and the protein and mRNA expression levels of related cytokines were measured by flow cytometry, ELISA and polymerase chain reaction, respectively. The balance of Th 1 , Th 2 , Th 17 and T reg cells in the peripheral blood of patients with lung cancer was disrupted following thoracotomy. TAES administration increased the percentage of Th 1 and Th 17 cells, the protein expression levels of interleukin (IL)-2 and interferon-γ, the mRNA expression levels of T-bet and RAR-related orphan receptor-γt, and decreased the percentage of Th 2 cells, IL-10 protein expression levels, and GATA binding protein 3 mRNA expression levels. The results of the present study demonstrated that TAES was able to partially attenuate the postoperative immune depression of patients with lung cancer, by regulating the balance of Th 1 , Th 2 , Th 17 and T reg cells, and the expression levels of related cytokines and transcription factors; therefore, TAES may be considered to be a promising strategy for treating postoperative immune dysfunction in patients with lung cancer.

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Section: Discussionsupporting

confidence: 92%

“…The results of the present study are in line with a previous study, in which electroacupuncture was able to improve surgery-suppressed immune function (28). Furthermore, this study reported that acupuncture and TAES were able to affect the immune system of patients undergoing major abdominal surgery (28).…”

Section: Discussionsupporting

confidence: 92%

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Wang

et al. 2015

Experimental and Therapeutic Medicine

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“…Despite recent advances in the medical and surgical fields that have improved postoperative results, certain patients continue to develop severe infections and require a repeat operation, which is associated with increased morbidity and mortality [9, 10]. Therefore, methods that are complementary to conventional postoperative treatment for reducing inflammation and regulating immune function are needed.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and immune regulatory effects of acupuncture after craniotomy: study protocol for a parallel-group randomized controlled trial

Cho

Yang

Shin

et al. 2017

Trials

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BackgroundDespite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop infections severe enough to require a repeat operation despite antibiotic prophylaxis. Acupuncture has been used to treat inflammatory conditions, and many basic and clinical studies have provided evidence of its anti-inflammatory and immune regulatory effects. The aim of this study is to explore the effects of acupuncture on inflammation and immune function after craniotomy.MethodsThis trial will be a single-center, parallel-group clinical trial. Forty patients who underwent craniotomy for an unruptured aneurysm, facial spasm, or a brain tumor will be allocated to either the study or the control group. The study group will receive conventional management as well as acupuncture, electroacupuncture, and intradermal acupuncture, which will start within 48 h of the craniotomy. The patients will receive a total of six sessions within 8 days. The control group will only receive conventional management. The primary outcome measure will be the C-reactive protein levels, while the secondary outcomes will be the serum erythrocyte sedimentation rate and the tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels measured at four different time points: within 48 h prior to the craniotomy and on days 2, 4, and 7 after surgery. The presence of fever and infection, the use of additional antibiotics, the presence of infection, including pneumonia or urinary tract infection, and safety will also be investigated.DiscussionIn this trial, we will observe whether acupuncture has anti-inflammatory and immune regulatory effects after a craniotomy. If our study yields positive results and a placebo-controlled study also finds favorable results following our study, acupuncture could be recommended as an adjunctive therapy after a craniotomy.Trial registrationClinicalTrials.gov: NCT02761096. Registered on 27 April 2016. Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1712-7) contains supplementary material, which is available to authorized users.

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“…Among them, 5 studies29549095107 were published between 1992 and 1999; 33 studies22242527303138454752535657586768717273747778818384929397104105106110111 were published between 2000 and 2010; the remaining 56 studies1819202123262832333435363739404142434446484950515559606162636465666970757679808285868788899194969899100101102103108109 were reported from 2010 to 2015 (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Sham Electroacupuncture Methods in Randomized Controlled Trials

Chen

Zhang

et al. 2017

Sci Rep

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Sham electroacupuncture (EA) control is commonly used to evaluate the specific effects of EA in randomized-controlled trials (RCTs). However, establishing an inert and concealable sham EA control remains methodologically challenging. Here, we aimed to systematically investigate the sham EA methods. Eight electronic databases were searched from their inception to April 2015. Ten out of the 17 sham EA methods were identified from 94 RCTs involving 6134 participants according to three aspects: needle location, depth of needle insertion and electrical stimulation. The top three most frequently used types were sham EA type A, type L and type O ordinally. Only 24 out of the 94 trials reported credibility tests in six types of sham EA methods and the results were mainly as follows: sham EA type A (10/24), type B (5/24) and type Q (5/24). Compared with sham EA controls, EA therapy in 56.2% trials reported the specific effects, of which the highest positive rate was observed in type N (3/4), type F (5/7), type D (4/6) and type M (2/3). In conclusion, several sham EA types were identified as a promising candidate for further application in RCTs. Nonetheless, more evidence for inert and concealable sham EA control methods is needed.

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The effect of electroacupuncture on postoperative immunoinflammatory response in patients undergoing supratentorial craniotomy

Cited by 18 publications

References 10 publications

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Anti-inflammatory and immune regulatory effects of acupuncture after craniotomy: study protocol for a parallel-group randomized controlled trial

Sham Electroacupuncture Methods in Randomized Controlled Trials

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