The Effect of Early Life Stress on Memory is Mediated by Anterior Hippocampal Network

Xu, Jingjing; Guan, Xiaojun; Li, Hong; Zhang, Minming; Xu, Xiaojun

doi:10.1016/j.neuroscience.2020.10.018

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…Also, stressful life events ease the access and entry to the working memory of controlling ideas associated with these events, thus using up the limited resources of the working memory and affecting the sources of attention as one of the cognitive inputs affecting information processing. This result is consistent with the studies of Goller et al (2020), Xu et al (2020) and Zhang et al (2018), who explained that high levels of pressure are connected to a change in the capacity of the working memory, and also with the study of Blasiman and Was (2018) who stated that pressure level instructions are related to fluctuations in the level of capacity of the working memory.…”

Section: Discussionsupporting

confidence: 92%

Examining the stress, depressive thoughts, and working memory capacities of the university students

Hamza

Helal

2021

Journal for the Education of Gifted Young Scientists

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The objective of the study is to measure the capacity of the working memory, and also to investigate its relationship to life stress and depressive thoughts. The study sample consisted of 50 college students studied on Science and Art major. A cognitive task was designed to measure the working memory capacity based on the determinants found in previous research. The results indicated that there were statistically significant differences in the level of life stress events (high/low) on the task of measuring the working memory capacity. The results also showed that there were no statistically significant differences neither between genders nor between majors on the task of measuring the working memory capacity. Furthermore, the results reported that there was no statistically significant effect of the interaction of the level of life stress (high/low) and gender (male/female) on the task of measuring working memory capacity. Finally, the results reported that there were significant differences in the level of depressive thoughts (high/low) on the task of measuring working memory. The current research concludes that neither the interaction of stressful life events, gender, and academic major, nor the interaction of depressive thoughts, gender, and academic major have an effect on working memory capacity.

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Section: Discussionsupporting

confidence: 92%

Examining the stress, depressive thoughts, and working memory capacities of the university students

Hamza

Helal

2021

Journal for the Education of Gifted Young Scientists

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“…, 2015 ; McLaughlin et al. , 2016 ); and activation of/connectivity between the anterior and posterior hippocampus subregions ( Xu et al. , 2020 ), may also serve as biological mediators between polyvictimization and trait anxiety.…”

Section: Discussionmentioning

confidence: 99%

Stress-related hippocampus activation mediates the association between polyvictimization and trait anxiety in adolescents

Corr

Glier

Bizzell

et al. 2021

Social Cognitive and Affective Neuroscience

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Early life stress exposures are associated with adverse health outcomes and heightened anxiety symptoms in adolescents. Stress-sensitive brain regions like the hippocampus and amygdala are particularly impacted by early life adversities and are also implicated in the development of anxiety disorders. However, to date no studies have specifically examined the neural correlates of polyvictimization (exposure to multiple categories of victimization) or the contribution of stress-sensitive neural nodes to polyvictimization’s impact on mental health. To elucidate these relationships, the current study analyzed associations between polyvictimization, hippocampal and amygdalar activation during an acute stress task, and trait anxiety in a sample of 80 children and adolescents aged 9-16 years (33 female). Results showed that polyvictimization was associated with higher trait anxiety as well as greater stress-related right hippocampus activation, and this greater hippocampal activity predicted heightened trait anxiety. Robust mediation analyses revealed that stress-related right hippocampus activation partially mediated the relationship between polyvictimization and trait anxiety. Our results expand upon the existing polyvictimization literature by suggesting a possible neurobiological pathway through which polyvictimization is connected to the etiology of mental illness.

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A systematic review of childhood maltreatment and resting state functional connectivity

Gerin,

Viding,

Herringa

et al. 2023

Developmental Cognitive Neuroscience

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The Effect of Early Life Stress on Memory is Mediated by Anterior Hippocampal Network

Cited by 4 publications

References 67 publications

Examining the stress, depressive thoughts, and working memory capacities of the university students

Examining the stress, depressive thoughts, and working memory capacities of the university students

Stress-related hippocampus activation mediates the association between polyvictimization and trait anxiety in adolescents

A systematic review of childhood maltreatment and resting state functional connectivity

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