The effect of duodenal infusion on the electromyogram of gastric muscle during activation and inhibition of gastric emptying.

Bell, F. R.; Ml, Grivel

doi:10.1113/jphysiol.1975.sp010980

Cited by 34 publications

(25 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The precise mechanisms by which these effects are exerted are not well understood, but both nervous and hormonal/humoral links may be involved. In the case of the interactions between the duodenal receptors and gastric muscular effectors, the pathway(~) must be either via extrinsic nerves or be hormonal (Bell & Grivel 1975).…”

Section: The Physiological Backgroundmentioning

confidence: 99%

Mythical models of gastric emptying and implications for food consumption studies

Jobling

1986

Environ Biol Fish

107

View full text Add to dashboard Cite

SynopsisTwo of the rnost important factors governing gastric emptying are meal volume and food composition. These factors have also been demonstrated to influence the secretion of gastric acid, digestive enzymes and gut hormones in both fish and mammals. In mammals, feedback loops involving gastrointestinal hormones have been implicated in the control of gastric motility and enzyme secretion. These findings are briefly reviewed and it is demonstrated how the functioning of the feedback loops could lead to changes in gastric emptying patterns. A simulation exercise was carried out incorporating these physiological observations into the emptying model. The results predicted that an exponential function would best describe the emptying of small, easily digested low energy food particles from the stomach, but that a linear expression would give a better fit to the emptying data when food consisted of high energy large sized particles. These predictions were supported by results obtained in a number of experimental studies. These results are discussed in terms of selecting methods for the estimation of daily food consumption of fish species.

show abstract

Section: The Physiological Backgroundmentioning

confidence: 99%

Mythical models of gastric emptying and implications for food consumption studies

Jobling

1986

Environ Biol Fish

107

View full text Add to dashboard Cite

show abstract

“…This result indicates that all three gastric functions are inhibited simultaneously. Since it has been shown that inhibition of action potentials of smooth muscle results from acid in the duodenum Grivel, 1975) and is associated with quiescence of the gastric body and antrum (Bell, 1978), then the reduction of gastric secretion to basal levels noted in the present observations may also reflect a similar inhibitory effect from duodenal acid receptors. When the duodenum is perfused with isotonic NaHCO3 the functions ofthe stomach are enhanced, the abomasum empties most of the test meal in 45 min, and gastric acid and pepsinogen secretion is increased by a factor of two to three compared to acid perfusion.…”

Section: Resultsmentioning

confidence: 59%

“…We have examined the triple response of gastric emptying, acid secretion, and pepsinogen secretion when the duodenum is perfused with either 60 mM-HCl, which is known to retard physiological processes in the stomach, and isotonic NaHCO3 which is known to enhance these processes (Bell & Mostaghni, 1975;Bell & Grivel, 1975;Bell & Watson, 1976).…”

Section: Introductionmentioning

confidence: 99%

Gastric emptying and secretion in the calf on duodenal infusion of tryptophan, tryptamine and 5‐hydroxytryptamine

Bell

Webber

1979

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Gastric emptying, gastric acid and pepsinogen secretion were assessed simultaneously in the conscious calf using the test meal and duodenal perfusion technique (Bell & Mostaghni, 1975).2. When 60 mM-HCl was infused into the duodenum, gastric emptying was arrested but both acid and pepsinogen secretion continued at a low level. Duodenal infusion with isotonic NaHCO3 caused rapid exponential emptying of the test meal and acid and pepsinogen output was more than doubled.3. Duodenal infusion of amino acids in isotonic NaHCO3 did not affect the rapid emptying, except infusion with tryptophan, which caused a measureable degree of inhibition of emptying, with concomitant effects on acid and pepsinogen secretion 4. Tryptamine and 5-hydroxytryptamine (5-HT) incorporated in low concentration into isotonic NaHCO3 also produced depression of gastric emptying, acid and pepsinogen levels comparable to the response initiated by acid infusate. Tryptophan was effective only in non-physiological amounts while 5-HT and tryptamine were active in smaller doses.5. Our results suggest that the inhibition of gastric emptying following duodenal infusion of tryptophan noted by Stephens, Woolson & Cooke (1975) may be due to the duodenal synthesis of its biogenic amine derivatives tryptamine and 5-HT.6. The level of activity of the three gastric functions, emptying, acid secretion and pepsinogen secretion appears to be linked. A single stimulus, therefore, could evoke a duodenal receptor or receptors to mediate or suppress activity of the gastric smooth muscle and secretary cells through interrelated mechanisms. The effect of some duodenal infusates, however, produces some variability in response which suggests differential activation of different receptors with consequent variable motor activity on effector cells.

show abstract

“…11 Gastric emptying is considered to be the result of a complex coordination between proximal stomach tonus and pylorusduodenal relaxations. [12][13][14] In order to assess the effects of sildenafil on small intestine contractile activity, we decided to investigate its effects on spontaneous and chemically stimulated motor behaviour of rat duodenal segments.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of sildenafil on rat duodenal contractility In vitro: Putative cGMP involvement

Araújo

Clemente

Graça

et al. 2005

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. Sildenafil citrate (Viagratrade mark; Pfizer, Sandwich, Kent, UK), a phosphodiesterase 5 inhibitor, rises cGMP levels in smooth muscle cells. It relaxes both vascular and visceral smooth muscle. In order to assess the intestinal effects of sildenafil, we decided to investigate its actions on rat duodenal motor activity in vitro. 2. In isolated duodenal segments maintained in Tyrode's solution, sildenafil exhibited a concentration-dependent antispasmodic effect on acetylcholine (ACh)-induced phasic contractions, with an IC50 value of 26.7 micromol/L (95% confidence interval (CI) 2.0-55.3 micromol/L). 3. Sildenafil also relaxed the carbamylcholine (CCh)-induced sustained contraction with an IC(50) of 16.2 micromol/L (95% CI 9.5-27.6 micromol/L). Sildenafil produced significant additional relaxation of 25.2 +/- 8.1% of the CCh-induced contraction, beyond basal tone. 4. Sildenafil reduced the amplitude of spontaneous duodenal contractions with an EC50 of 9.6 micromol/L (95% CI 5.7-16.2 micromol/L). This effect was significantly more potent than the effects of zaprinast and papaverine, which also reduced duodenal contractions with EC50 values of 91.6 micromol/L (95% CI 46.0-182.2 micromol/L) and 78.5 micromol/L (95% CI 37.1-166.3 micromol/L), respectively. 5. In preparations treated previously with methylene blue (10 micromol/L) or 1H-[1,2,4]oxadiazolo(4,3-a)quinoxalin-1-one (ODQ; 10 micromol/L), the EC50 values for the sildenafil effect were significantly increased to 39.0 micromol/L (95% CI 23.9-63.4 micromol/L) and 43.8 micromol/L (95% CI 24.5-78.3 micromol/L), respectively. These values were significantly greater than those obtained with sildenafil alone. 6. In conclusion, sildenafil has myorelaxant and antispasmodic effects on rat duodenal segments in vitro. The contractile inhibitory effect of sildenafil on rat isolated duodenum is probably due to intracellular cGMP accumulation as a result of its decreased degradation.

show abstract

The effect of duodenal infusion on the electromyogram of gastric muscle during activation and inhibition of gastric emptying.

Cited by 34 publications

References 7 publications

Mythical models of gastric emptying and implications for food consumption studies

Mythical models of gastric emptying and implications for food consumption studies

Gastric emptying and secretion in the calf on duodenal infusion of tryptophan, tryptamine and 5‐hydroxytryptamine

Inhibitory effect of sildenafil on rat duodenal contractility In vitro: Putative cGMP involvement

Contact Info

Product

Resources

About