The effect of drag reducing agents on stenotic flow disturbances in dogs

Mostardi, Richard A.; Greene, Howard L.; Nokes, Richard F.; Thomas, L. C.; Lue, Tammy

doi:10.3233/bir-1976-13208

Cited by 31 publications

(20 citation statements)

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“…The results obtained in this test series are in good agreement with the previously reported decreases in the number of atherosclerotic plaques in rabbits and birds fed an atherogenic diet and injected intravenously with Separan [8,10], a polymer chemically distinct from PEO. Recently, similar results have been obtained for rabbits using PEO [3].…”

Section: Resultssupporting

confidence: 80%

Prophylactic and corrective action of the polyethylene oxide polyox WSR-301 in rats with experimental lipoidosis

et al. 1995

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Two once-weekly intravenous injections of the polyethylene oxide Polyox WSR-301 (yielding a blood concentration of the order of 5• .6 g/ml) led to a 38% decrease in the area occupied by sudanophilic lesions in the aortic arch of rats fed an atherogenic diet for two weeks. Perfusion under constant pressure of the formalin-fLxed vascular system in the posterior part of the body with physiological saline and then with polyethylene oxide (10 -s g/ml) was without effect in normal rats and in those with mild lipoidosis, but reduced hydrodynamic vascular resistance by 9-14.5% in rats with pronounced lipoidosis. Intravenous injection of polyethylene oxide into anesthetized rats with pronounced lipoidosis in doses that were subthreshold for normal rats (blood concentrations of the polymer were of the order of 10 -7 g/ml) caused a 20% decrease in the total peripheral resistance to blood flow, with a 17-20% rise of the blood flow rate in the carotid artery.

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Section: Resultssupporting

confidence: 80%

Prophylactic and corrective action of the polyethylene oxide polyox WSR-301 in rats with experimental lipoidosis

et al. 1995

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“…Interestingly, the first in vitro (Greene, Nokes, & Thomas, 1970Hoyt, 1971;Stein, Parsons, & Blick, 1972) and in vivo (Greene, Thomas, Mostardi, & Nokes, 1974;Mostardi, Greene, Nokes, Thomas, & Lue, 1976) studies of the DRP effects on blood circulation were initiated and performed by chemical or mechanical engineers and physicists who most likely were not aware that the Reynolds numbers in the cardiovascular system were too low for DRP to generate Toms phenomenon (especially, in small animals which were mostly used in those studies). Injections or infusions of minute concentrations of various synthetic and natural DRPs in the blood circulation resulted in improvements of macro and microcirculation in a variety of pathological states and species such as a decrease in blood pressure in rats with induced hypertension (Grigorian & Kameneva, 1990;, an increase in the density of functioning capillaries in diabetic animals (Golub, Grigorian, Kameneva, Malkina, & Shoshenko, 1987), an increase in the myocardial perfusion and the animal survival after induced myocardial infarction (Pacella, Kameneva, & Villanueva, 2009;Pacella et al, 2006;Sakai, Repko, Griffith, Waters, & Kameneva, 2007), significant increase in the survival rate after exposure to lethal hemorrhage (Cotoia, Kameneva, Marascalco, Fink, & Delude, 2009;Dubick et al, 2008;Kameneva et al, 2004;Macias, Kameneva, Tenhunen, Puyana, & Fink, 2004), and many others.…”

Section: Introductionmentioning

confidence: 98%

Microrheological effects of drag-reducing polymers in vitro and in vivo

Kameneva¹

2012

International Journal of Engineering Science

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“…This phenomenon, known as turbulent drag reduction (DR), was discovered more than fifty years ago [4]. Numerous applications of DR are known, including transportation of crude oil in oil pipelines, increased jet velocity and beam focusing in fire fighting equipment, prevention of over dosage of water flow during heavy rain in drainage and irrigation systems, increase of volumetric flow rate of fluid in hydro-power systems, and improvement of blood flow in partially blocked arteries in biomedical studies [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%