The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease

Xu, Shuo; Zhou, Qihui; Jiang, Zucheng; Wang, Yanwen; Yang, Kai; Qiu, Xiaohui; Ji, Qiuxia

doi:10.1016/j.carbpol.2020.116163

Cited by 60 publications

(49 citation statements)

References 43 publications

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“…Recently, it has been demonstrated that biomaterials with unique (bio)physicochemical properties could mediate cell behaviors and even treat diseases, repair bodily functions, or regenerate tissues [6][7][8][9][10][11][12][13][14][15]. Particularly, the development of nanomaterials and their extensive application in diagnostic/therapeutic biomedicine has received much attention [16][17][18][19][20][21][22][23]. It is practicable to overcome conventional limitations of diagnosis and therapy with various nanoparticles (NPs) because of the particular anatomy and pathophysiological conditions of the tumor, such as angiogenesis, hypoxia, low extracellular pH, and lack of lymphatic drainage [24].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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Oral cancer is the sixth most common malignant cancer, affecting the health of people with an unacceptably high mortality rate. Despite numerous clinical methods in the diagnosis and therapy of oral cancer (e.g., magnetic resonance imaging, computed tomography, surgery, and chemoradiotherapy), they still remain far from optimal. Therefore, an urgent need exists for effective and practical techniques of early diagnosis and effective therapy of oral cancer. Currently, various types of nanoparticles have aroused wide public concern, representing a promising tool for diagnostic probes and therapeutic devices. Their inherent physicochemical features, including ultrasmall size, high reactivity, and tunable surface modification, enable them to overcome some of the limitations and achieve the expected diagnostic and therapeutic effect. In this review, we introduce different types of nanoparticles that emerged for the diagnosis and therapy of oral cancers. Then, the challenges and future perspectives for nanoparticles applied in oral cancer diagnosis and therapy are presented. The objective of this review is to help researchers better understand the effect of nanoparticles on oral cancer diagnosis and therapy and may accelerate breakthroughs in this field.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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“…Xu et al reported the loading of the antimicrobial agent doxycycline into polymeric nanoparticles composed of chitosan and carboxymethyl chitosan [124]. This nanoparticle was anticipated to penetrate the plaque biofilm more effectively and kill the bacteria.…”

Section: Polymeric Nanoparticles For Drug Delivery and Immunomodulationmentioning

confidence: 99%

“…Doxycycline is a well know immuno-modulatory agent, hence this nanoparticle system was also investigated as a host-directed immune-therapy for periodontitis. The nanoparticles were reported to effectively down-regulate the mRNA and protein levels of NLRP3 inflammasome and IL-1β in human gingival fibroblasts [124]. The NLRP3 inflammasome plays an important role in regulating innate immune responses in periodontitis [125].…”

Section: Polymeric Nanoparticles For Drug Delivery and Immunomodulationmentioning

confidence: 99%

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

et al. 2021

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The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.

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“…CS is one of the most used polysaccharides for the preparation of nanoparticles, having the advantage of an intrinsic antibacterial activity [ 91 ]. It is often used in combination with alginates [ 100 , 101 ] or with PLGA [ 103 , 104 , 105 ], associated with the collagen matrix [ 97 ], in the form of derivatives [ 97 , 98 ] or biocomposites.…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease

Cited by 60 publications

References 43 publications

Nanoparticles for Oral Cancer Diagnosis and Therapy

Nanoparticles for Oral Cancer Diagnosis and Therapy

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

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