The Effect of Dosing Frequency on the Pharmacokinetics of a Fentanyl HCl Patient-Controlled Transdermal System (PCTS)

Sathyan, Gayatri; Zomorodi, Katayoun; Gidwani, Shalini; Gupta, Suneel

doi:10.2165/00003088-200544001-00004

Cited by 29 publications

(13 citation statements)

References 6 publications

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“…The amount of fentanyl absorbed by patients was found to be directly proportional to the magnitude of current applied by the system, with a 170 μA current producing absorption of approximately 40 μg fentanyl and a coefficient of variation similar to that of iv fentanyl infusion (22% and 23%, respectively) (Sathyan et al 2005a). A separate study found that fentanyl absorption increases with time; in the first hour of treatment approximately 40% of each 40 μg bolus dose of fentanyl is absorbed; however after 10 hours of ITS therapy almost 100% of each 40 μg bolus is absorbed (Sathyan et al 2005b). Although the reasons for the increase in fentanyl absorption over time are not entirely clear, it may result from the reversible alterations in the electrical conduction properties of skin that occur during exposure to electric current from the system (Curdy et al 2001).…”

Section: Overview Of Itsmentioning

confidence: 99%

“…Although the reasons for the increase in fentanyl absorption over time are not entirely clear, it may result from the reversible alterations in the electrical conduction properties of skin that occur during exposure to electric current from the system (Curdy et al 2001). Absorption of fentanyl was not affected, however, by variations in the frequency of dosing or patient characteristics, such as age, gender, ethnicity, and weight (Sathyan et al 2005b). …”

Section: Overview Of Itsmentioning

confidence: 99%

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Advances in patient-controlled analgesia: the role of fentanyl ITS

Power¹,

McCormack²

2009

MDER

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Effective pain relief is an essential component of a patient’s peri-operative care package. Good analgesia has been shown to reduce the incidence of cardiovascular, respiratory and thrombo-embolic complications following surgery. Satisfactory analgesia facilitates early patient ambulation following surgery, which may reduce in-patient stay. Patient-controlled analgesia (PCA) systems are a well established standard therapy for acute post-operative pain; however some practical limitations limit their clinical utility. The fentanyl inotophoretic transdermal system (ITS) is a novel self-contained needle-free PCA device, which delivers boluses of fentanyl transdermally. This system has been shown to provide analgesia equivalent to conventional PCA modalities, with unique design features that may confer advantages to patients and staff, including facilitating patient mobilization in the post-operative phase. This review will discuss the technology of iontophoretic systems, the pharmacology of transdermal fentanyl delivery, and some practical implications of the fentanyl ITS.

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Section: Overview Of Itsmentioning

confidence: 99%

Section: Overview Of Itsmentioning

confidence: 99%

Advances in patient-controlled analgesia: the role of fentanyl ITS

Power¹,

McCormack²

2009

MDER

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“…The system also avoids the potential for programming errors. 40 According to the fentanyl PCTS Clinical Trial and Routine Practice panels, less nursing time was consumed and fewer tasks were required with fentanyl PCTS than for IV PCA. 41 …”

Section: Fentanyl Delivered By Transdermal Iontophoresismentioning

confidence: 99%

Emerging Trends and New Approaches to Acute Pain Management

Polomano

Rathmell²,

Krenzischek³

et al. 2008

Journal of PeriAnesthesia Nursing

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“…3). 48 Although the reasons for the increase in fentanyl absorption over time are not entirely clear, it may result from reversible alterations in the electrical conduction properties of skin that occur during exposure to electric current from the system. Absorption of fentanyl was not affected, however, by variations in the frequency of dosing or patient characteristics, such as age, gender, ethnicity and weight.…”

Section: Pharmacokinetics Of Transdermal Fentanyl Administration: Pasmentioning

confidence: 99%

Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain

Power

2007

British Journal of Anaesthesia

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The fentanyl HCl iontophoretic transdermal system (fentanyl ITS) is a novel patient-controlled analgesia (PCA) system that has been approved in the USA and Europe for the management of acute, moderate-to-severe postoperative pain. This system extends the applicability of transdermal drug delivery to acute pain management, allowing patients to self-administer pre-programmed doses of fentanyl non-invasively through the use of iontophoretic technology. Iontophoresis is the process by which an electric current is used to drive ionized drug molecules across the skin and into the systemic circulation. Results of a recent US clinical trial found the fentanyl ITS to provide pain control equivalent to a standard regimen of morphine i.v. PCA, with a similar incidence of opioid-related adverse events. The fentanyl ITS may offer a number of clinical advantages over existing PCA modalities. Its method of drug delivery avoids the risk of complications from needle-related injuries and infection, and its pre-programmed electronics eliminate the potential for manual programming errors and excessive dosing. In addition, the compact size of the system could enable greater patient mobility following surgery. The fentanyl ITS has the potential to become a valuable option in the management of acute postoperative pain.

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The Effect of Dosing Frequency on the Pharmacokinetics of a Fentanyl HCl Patient-Controlled Transdermal System (PCTS)

Abstract: The amount of fentanyl absorbed from the PCTS increases as a function of time and is independent of both dosing frequency and total number of doses delivered. The fentanyl HCl PCTS is generally safe and well tolerated.

Cited by 29 publications

References 6 publications

Advances in patient-controlled analgesia: the role of fentanyl ITS

Advances in patient-controlled analgesia: the role of fentanyl ITS

Emerging Trends and New Approaches to Acute Pain Management

Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain

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