Abbreviated title: Multivoxel codes for acoustic features 14 15 Keywords: auditory cortex; parietal cortex; fMRI; multivariate; feature binding 16 17 Acknowledgements: We are grateful to Carsten Allefeld for advice with 18 crossvalidated MANOVA.
Abstract
29Using fMRI and multivariate pattern analysis, we determined whether acoustic 30 features are represented by independent or integrated neural codes in human 31 cortex. Male and female listeners heard band-pass noise varying 32 simultaneously in spectral (frequency) and temporal (amplitude-modulation 33[AM] rate) features. In the superior temporal plane, changes in multivoxel 34 activity due to frequency were largely invariant with respect to AM rate (and 35 vice versa), consistent with an independent representation. In contrast, in 36 posterior parietal cortex, neural representation was exclusively integrated and 37 tuned to specific conjunctions of frequency and AM features. Direct between-38 region comparisons show that whereas independent coding of frequency and 39 AM weakened with increasing levels of the hierarchy, integrated coding 40 strengthened at the transition between non-core and parietal cortex. Our 41 findings support the notion that primary auditory cortex can represent 42 component acoustic features in an independent fashion and suggest a role for 43 parietal cortex in feature integration and the structuring of acoustic input. 44 45 Significance statement 46 A major goal for neuroscience is discovering the sensory features to which the 47 brain is tuned and how those features are integrated into cohesive perception. 48We used whole-brain human fMRI and a statistical modeling approach to 49 quantify the extent to which sound features are represented separately or in 50 an integrated fashion in cortical activity patterns. We show that frequency and 51 AM rate, two acoustic features that are fundamental to characterizing 52 biological important sounds such as speech, are represented separately in 53 primary auditory cortex but in an integrated fashion in parietal cortex. These 54 findings suggest that representations in primary auditory cortex can be 55 simpler than previously thought and also implicate a role for parietal cortex in 56 integrating features for coherent perception. 57 58 59 60