The Effect of Disodium Cromoglycate on Asthma in Children.

Abstract

SYNOPSIS A double blind study using disodium chromoglycate and a placebo was undertaken during the pollen season in Perth. 7 children with severe asthma were investigated and most showed improvement in symptoms, by day and night 5 of the 7 showed improvement in respiratory function studies at the end of the period on disodium cromoglycate. It is concluded that this compound is of value in the treatment of the asthmatic child.

Sodium Cromoglycate (Cromolyn Sodium)

“…In a double-blind trial in 7 children who suffered severe exacerbations of their asthma during the pollen season, Hobday (1970) reported that during the daytime, wheeze improved in 6 patients, breathlessness in 5, chest tightness and cough in 4 and sputum appearance in 3. These symptoms were improved in a similar proportion of patients at night and all 7 were woken less often.…”

“…In studies giving individual results, the average increase in FEV 1 amongst patients who showed some improvement in dynamic lung volumes during short-term treatment has ranged from 7 to 700 % (Bakir et al, 1970;Gianoutsos and O'Donnell, 1969;Hobday, 1970;Momson Smith and Devey, 1968; and the average increase in PEF amongst those showing some increase has ranged from 31 to 76 % (Robertson et aI., 1969;Bakir et al, 1970). In studies giving individual results, the average increase in FEV 1 amongst patients who showed some improvement in dynamic lung volumes during short-term treatment has ranged from 7 to 700 % (Bakir et al, 1970;Gianoutsos and O'Donnell, 1969;Hobday, 1970;Momson Smith and Devey, 1968; and the average increase in PEF amongst those showing some increase has ranged from 31 to 76 % (Robertson et aI., 1969;Bakir et al, 1970).…”